Article
Peripheral Vascular Disease
Shuhan Jiang, Wei Zhang, Qing Cao, Maryam Rahbar, William Cooke, Masayuki Ono, Kenichi Fujimaki, Atsushi Saito, Makoto Itonaga, Kenta Oda, Christopher Redman, Manu Vatish
Summary: The ExoCounter assay developed in this study can detect small placental extracellular vesicles in the plasma of pregnant women at high risk of developing preeclampsia, providing an opportunity for early intervention.
Article
Peripheral Vascular Disease
Xiu Liu, Haiyi Fei, Cuiyu Yang, Jianmin Wang, Xiaohong Zhu, Anran Yang, Zhan Shi, Xiaoying Jin, Fei Yang, Dan Wu, Lingling Jiang, Songying Zhang
Summary: In preeclamptic placentas, macrophages shift from M2 to M1 phenotype; T-EVs from women with PE can induce macrophage imbalance polarization by affecting inflammatory pathways, promoting the development of preeclampsia.
Review
Biochemistry & Molecular Biology
Natalia Gebara, Yolanda Correia, Keqing Wang, Benedetta Bussolati
Summary: Angiogenesis, regulated by extracellular vesicles (EVs) from gestational tissues, plays a crucial role in healthy pregnancy and is dysregulated in pregnancy-related diseases like preeclampsia. The use of EVs from placental stem cells shows promise in clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Toluwalase Awoyemi, Carolina Motta-Mejia, Wei Zhang, Lubna Kouser, Kirsten White, Neva Kandzija, Fatimah S. Alhamlan, Adam P. Cribbs, Dionne Tannetta, Emily Mazey, Christopher Redman, Uday Kishore, Manu Vatish
Summary: Our study showed that STBEV from LOPE placentae have a lesser immune-modulatory effect on macrophages compared to NP placentae. NP STBEV induced the release of pro-inflammatory cytokines from macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yourong Feng, Qi Chen, Sien Yee Lau, Bridget W. Tsai, Katie Groom, Carolyn J. Barrett, Lawrence W. Chamley
Summary: Placental extracellular vesicles (EVs) play a crucial role in feto-maternal communication and their uptake by recipient cells involves various mechanisms such as time, concentration, energy-dependence, as well as phagocytosis and endocytosis. The interaction between placental EVs and recipient cells is mediated by integrins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Zongli Ren, Ning Cui, Minglin Zhu, Raouf A. Khalil
Summary: The study suggests that placental ischemia-induced proinflammatory cytokines may be one of the causes of preeclampsia. Modulating cytokines and metalloproteinases can improve vascular and uteroplacental remodeling, alleviating symptoms of preeclampsia.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jiajia Jin, Liaomei Gao, Xiuli Zou, Yun Zhang, Zhijian Zheng, Xinjie Zhang, Jiaxuan Li, Zhenyu Tian, Xiaowei Wang, Junfei Gu, Cheng Zhang, Tiejun Wu, Zhe Wang, Qunye Zhan
Summary: The study revealed gut microbiota dysbiosis in preeclamptic patients, with reductions in specific bacteria and short-chain fatty acids. Experiments on preeclamptic rats showed that gut microbiota from healthy pregnant women had protective effects, while specific microbes and metabolites could alleviate preeclampsia symptoms.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Toluwalase Awoyemi, Wei Zhang, Maryam Rahbar, Adam Cribbs, Prasanna Logenthiran, Shuhan Jiang, Gavin Collett, Ana Sofia Cerdeira, Manu Vatish
Summary: By studying the differences in transcriptome between placenta and STB-EVs in preeclampsia and normal pregnancy, we have identified potential biomarkers and mechanistic gene pathways that may play important roles in the pathophysiology of preeclampsia and could be further explored in future studies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Mohammadrahim Kazemzadeh, Miguel Martinez-Calderon, Song Y. Paek, MoiMoi Lowe, Claude Aguergaray, Weiliang Xu, Lawrence W. Chamley, Neil G. R. Broderick, Colin L. Hisey
Summary: Placental extracellular vesicles (EVs) play important roles in pregnancy, but they are also implicated in the progression of preeclampsia. A fabrication process called laser-induced nano-structuring of SERS-active thin films (LINST) was developed to produce substrates that allow the biochemical fingerprinting of EVs. The findings encourage the exploration of surface-enhanced Raman spectroscopy (SERS) of EVs as a promising method for preeclampsia liquid biopsies.
Review
Biochemistry & Molecular Biology
Nadja Kupper, Berthold Huppertz
Summary: This article discusses the importance of the placental exposome on maternal health and normal pregnancy development, as well as the role and interaction of placenta-derived extracellular vesicles in this process.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Hongmei Qu, Raouf A. Khalil
Summary: The processes of normal pregnancy and preeclampsia involve the regulation by proteolytic enzymes such as ADAMs and ADAMTS. Insufficient trophoblast invasion, inadequate uterine wall vascular remodeling, and placental ischemia/hypoxia are major factors in the pathogenesis of preeclampsia.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christina. L. L. Herrera, Yiming Wang, Durga Udayakumar, Yin Xi, Quyen. N. N. Do, Matthew. A. A. Lewis, David. M. M. Owen, Baowei Fei, Catherine. Y. Y. Spong, Diane. M. M. Twickler, Ananth. J. J. Madhuranthakam
Summary: This study evaluates placental perfusion in normal pregnancies and pregnancies affected by chronic hypertension using pseudo-continuous arterial spin-labeled (pCASL) MRI. The results show a decline in placental perfusion in the second trimester of normal pregnancies, while it remained unchanged in cHTN pregnancies. Additionally, significantly lower placental perfusion was observed in pregnancies with infants that were small for gestational age. Therefore, pCASL-MRI-measured perfusion may serve as an effective imaging biomarker for placental insufficiency.
EUROPEAN RADIOLOGY
(2023)
Review
Obstetrics & Gynecology
Lingli Li, Luping Liu, YuYue Xu
Summary: A meta-analysis explored the potential relationship between hypertensive disease during pregnancy and placenta accreta, finding that hypertensive disease during pregnancy was associated with a lower prevalence of placenta accreta.
REPRODUCTIVE SCIENCES
(2022)
Article
Peripheral Vascular Disease
Brooke Grimaldi, Hamid-Reza Kohan-Ghadr, Chidambra D. Halari, Pinki Nandi, John C. Kingdom, Sascha Drewlo
Summary: Activation of PPAR gamma in the preeclampsia placenta promotes cell growth and antioxidative stress pathways. Rosiglitazone restores HO1 signaling in a PPAR gamma-dependent manner, offering a potential therapeutic pathway to reverse placental damage and reduce maternal sequelae. Future research should focus on understanding impaired PPAR gamma signaling in the human placenta and identifying safe compounds for preventing severe perinatal morbidity and mortality.
Article
Immunology
Rachel R. Zabel, Christin Baer, Jinlu Ji, Rowena Schultz, Martin Hammer, Tanja Groten, Ekkehard Schleussner, Diana M. Morales-Prieto, Udo R. Markert, Rodolfo R. Favaro
Summary: The study successfully enriched and characterized different populations of placental EVs through ex vivo perfusion, demonstrating their characteristic features such as size, protein and RNA content, surface marker expression, as well as their uptake in immune cells and transfer of miRNA to recipient cells. This research advocates for the use of ex vivo placenta perfusion as a robust method for collecting placental EVs.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Letter
Obstetrics & Gynecology
Ana Sofia Cerdeira, Tim James, Manu Vatish
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Letter
Obstetrics & Gynecology
Ana Sofia Cerdeira, Joe O'Sullivan, Eric O. Ohuma, Tim James, Aris T. Papageorghiou, Marian Knight, Manu Vatish
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Medical Laboratory Technology
Samuel Dockree, Brian Shine, Lawrence Impey, Lucy Mackillop, Harpal Randeva, Manu Vatish
Summary: This study proposes the use of pregnancy-specific reference intervals (RIs) to interpret investigations during pregnancy, with the aim to improve diagnostic accuracy by using gestational age-specific RIs. By mapping the trajectory of platelets in pregnant women, it is found that platelets below the 3rd centile in early pregnancy can accurately predict thrombocytopaenia at term.
CLINICA CHIMICA ACTA
(2022)
Article
Cell Biology
Chiara Tersigni, Muhammad Furqan Bari, Shijei Cai, Wei Zhang, Neva Kandzija, Alice Buchan, Fabrizio Miranda, Nicoletta Di Simone, Christopher W. Redman, Claire Bastie, Manu Vatish
Summary: In normal pregnancy, placental release of STBEVs carrying apoE may target liver cells and increase lipid synthesis, potentially meeting the nutritional needs of the growing foetus.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Peter W. Horby, Guilherme Pessoa-Amorim, Natalie Staplin, Jonathan R. Emberson, Mark Campbell, Enti Spata, Leon Peto, Nigel J. Brunskill, Simon Tiberi, Victor Chew, Thomas Brown, Hasan Tahir, Beate Ebert, David Chadwick, Tony Whitehouse, Rahuldeb Sarkar, Clive Graham, J. Kenneth Baillie, Buddha Basnyat, Maya H. Buch, Lucy C. Chappell, Jeremy Day, Saul N. Faust, Raph L. Hamers, Thomas Jaki, Edmund Juszczak, Katie Jeffery, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathryn Rowan, Guy Thwaites, Marion Mafham, Richard Haynes, Martin J. Landray
Summary: In patients hospitalized with COVID-19, aspirin was not associated with reductions in 28-day mortality or in the risk of progressing to invasive mechanical ventilation or death, but was associated with a small increase in the rate of being discharged alive within 28 days.
Review
Cell Biology
Abi G. Yates, Ryan C. Pink, Uta Erdbrugger, Pia R-M. Siljander, Elizabeth R. Dellar, Paschalia Pantazi, Naveed Akbar, William R. Cooke, Manu Vatish, Emmanuel Dias-Neto, Daniel C. Anthony, Yvonne Couch
Summary: Extracellular vesicles (EVs) play a critical role in maintaining the homeostasis of normal physiological systems, but our current understanding mainly comes from studying them in disease. Analyzing EVs in clinical samples can improve our understanding of their role in disease. However, a deeper understanding of the mechanisms by which they contribute to pathogenic processes is needed for therapeutic intervention.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Review
Cell Biology
Abi G. Yates, Ryan C. Pink, Uta Erdbrugger, Pia R-M. Siljander, Elizabeth R. Dellar, Paschalia Pantazi, Naveed Akbar, William R. Cooke, Manu Vatish, Emmanuel Dias-Neto, Daniel C. Anthony, Yvonne Couch
Summary: Previously considered cellular debris, extracellular vesicles (EVs) are now recognized as mediators of physiological and pathological functions in the body. They have the ability to transfer nucleic acids and proteins between distant organs, interact with target cells through their surface proteins, and play a role in health and disease through vesicle-bound lipids. EVs are crucial in the pathogenesis of diseases and the maintenance of system and organ homeostasis.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Letter
Endocrinology & Metabolism
Joseph O'Sullivan, Alexandra E. Cairns, Elena Plesca, Rebecca S. Black, Charlotte Frise, Manu Vatish, Ana Sofia Cerdeira
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Review
Obstetrics & Gynecology
Stefan Verlohren, Shaun P. Brennecke, Alberto Galindo, S. Ananth Karumanchi, Ljiljana B. Mirkovic, Dietmar Schlembach, Holger Stepan, Manu Vatish, Harald Zeisler, Sarosh Rana
Summary: Preeclampsia poses significant morbidity and mortality risks for both mother and baby. The discovery of circulating angiogenic factors in preeclampsia pathogenesis has advanced diagnosis and prognosis, but there is currently no consensus or clear guidance on their practical use in routine clinical practice.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Review
Obstetrics & Gynecology
Gabriel Davis Jones, William R. Cooke, Manu Vatish, Christopher W. G. Redman
Summary: Cardiotocography is a method that measures the human fetal heart rate and uterine activity using ultrasound. The Dawes-Redman system is an automated computer analysis system that allows robust analysis of cardiotocographic signal features, providing reliable assessment of fetal wellbeing in clinical applications.
MATERNAL-FETAL MEDICINE
(2022)
Article
Medicine, General & Internal
Peter W. Horby, Marion Mafham, Leon Peto, Mark Campbell, Guilherme Pessoa-Amorim, Enti Spata, Natalie Staplin, Jonathan R. Emberson, Benjamin Prudon, Paul Hine, Thomas Brown, Christopher A. Green, Rahuldeb Sarkar, Purav Desai, Bryan Yates, Tom Bewick, Simon Tiberi, Tim Felton, J. Kenneth Baillie, Maya H. Bitch, Lucy C. Chappell, Saul N. Faust, Thomas Jaki, Katie Jeffery, Edmund Juszczak, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathryn Rowan, David M. Weinreich, Richard Haynes, Martin J. Landray
Summary: This study evaluated the efficacy and safety of the combination therapy of casirivimab and imdevimab in patients hospitalized with COVID-19. The results showed that this combination therapy reduced the 28-day mortality rate in patients without detectable antibodies to SARS-CoV-2 infection at baseline, but not in those with detectable antibodies.