Article
Multidisciplinary Sciences
Tomomi Nishimura, Nobuyuki Kakiuchi, Kenichi Yoshida, Takaki Sakurai, Tatsuki R. R. Kataoka, Eiji Kondoh, Yoshitsugu Chigusa, Masahiko Kawai, Morio Sawada, Takuya Inoue, Yasuhide Takeuchi, Hirona Maeda, Satoko Baba, Yusuke Shiozawa, Ryunosuke Saiki, Masahiro M. M. Nakagawa, Yasuhito Nannya, Yotaro Ochi, Tomonori Hirano, Tomoe Nakagawa, Yukiko Inagaki-Kawata, Kosuke Aoki, Masahiro Hirata, Kosaku Nanki, Mami Matano, Megumu Saito, Eiji Suzuki, Masahiro Takada, Masahiro Kawashima, Kosuke Kawaguchi, Kenichi Chiba, Yuichi Shiraishi, Junko Takita, Satoru Miyano, Masaki Mandai, Toshiro Sato, Kengo Takeuchi, Hironori Haga, Masakazu Toi, Seishi Ogawa
Summary: Recent studies have shown that clones carrying common cancer mutations frequently evolve in normal tissues, but we still lack knowledge about the additional driver events that occur before these clones evolve into cancer. In this study, using phylogenetic analyses, we found unique evolutionary histories in breast cancers with der(1;16), a common driver alteration. The timing of early evolutionary events was estimated and showed that both cancer and non-cancer clones evolved from a common ancestor in the patient's early 30s. Multiple independent cancer founders from non-cancer ancestors were also observed, contributing to intratumor heterogeneity. These findings provide new insights into the evolution of breast cancer.
Article
Medicine, General & Internal
Jiqing Li, Fabing Wang, Ruimei Xue, Shucheng Si, Fang Tang, Fuzhong Xue
Summary: Long-term exposure to antipsychotics increases TG burden and rate of TG increase in early life. The association between antipsychotics and CVD risk is stronger in the inverse-U group than in the low-decreasing group, and even stronger in the inverse-U trajectory and high TG group, indicating a potential higher risk of CVD in these subgroups.
Article
Medicine, General & Internal
Jiqing Li, Fabing Wang, Ruimei Xue, Shucheng Si, Fang Tang, Fuzhong Xue
Summary: The association between long-term antipsychotic exposure and triglycerides (TG) levels has been explored. It was found that long-term antipsychotic exposure increases TG burden and early increase rate, and the strength of the association with cardiovascular disease (CVD) risk is higher in the low-decreasing group compared to the inverse-U group.
Article
Multidisciplinary Sciences
Mei Lin, Xiao-Long Zhang, Rui You, You-Ping Liu, Hong-Min Cai, Li-Zhi Liu, Xue-Fei Liu, Xiong Zou, Yu-Long Xie, Ru-Hai Zou, Yi-Nuan Zhang, Rui Sun, Wei-Yi Feng, Hai-Yan Wang, Gui-Hua Tao, Hao-Jiang Li, Wen-Jie Huang, Chao Zhang, Pei-Yu Huang, Jin Wang, Qi Zhao, Qi Yang, Hong-Wan Zhang, Ting Liu, Hui-Feng Li, Xiao-Bing Jiang, Jun Tang, Yang-Kui Gu, Tao Yu, Zhi-Qiang Wang, Lin Feng, Tie-Bang Kang, Zhi-Xiang Zuo, Ming-Yuan Chen
Summary: To understand the metastasis of nasopharyngeal carcinoma, a genomic analysis was conducted on matched blood and tumor samples. Two distinct routes of metastasis were identified, one originating from lymph nodes and the other from primary tumors. The hematogenous route exhibited higher expression of IFN-gamma response genes and exhausted CD8(+) T cells. The hematogenous group showed better progression-free survival and PD-1 immunotherapy response, while the lymphatic group responded better to locoregional radiotherapy.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Fabio Magalhaes-Gama, Fabiola Silva Alves-Hanna, Nilberto Dias Araujo, Mateus Souza Barros, Flavio Souza Silva, Claudio Lucas Santos Catao, Julia Santos Moraes, Izabela Cabral Freitas, Andrea Monteiro Tarrago, Adriana Malheiro, Andrea Teixeira-Carvalho, Allyson Guimaraes Costa
Summary: The leukemic microenvironment contains diverse immune cells, including myeloid cells, that play important roles in regulating immune responses. The activation of different myeloid cell populations can have implications for immunosuppression, survival, metastasis, and tumor surveillance. Myeloid cell subpopulations have potential as predictive biomarkers and therapeutic targets in leukemia treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Zoology
Zhibin Zhang, Chuan Yan, Hongmao Zhang
Summary: This paper highlights the importance of mutualism between antagonistic species in regulating ecological and evolutionary processes, as well as maintaining the stability and complexity of ecosystems. Mutualism between antagonists can promote species coexistence and shape the dual character of species through balancing functional traits. Coevolution and co-balance of these traits are driving forces in shaping mutualism-antagonism systems.
INTEGRATIVE ZOOLOGY
(2021)
Article
Plant Sciences
Zheng Wang, Jinghua Yang, Feng Cheng, Peirong Li, Xiaoyun Xin, Weihong Wang, Yangjun Yu, Deshuang Zhang, Xiuyun Zhao, Shuancang Yu, Fenglan Zhang, Yang Dong, Tongbing Su
Summary: The review highlights the mechanistic basis of subgenome dominance and uses Brassica rapa as an example to show its impact on genome evolution and expression bias, as well as its role in intraspecific diversification.
HORTICULTURE RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Pradeep Kumar, Akshay Bhatnagar, Rajan Sankaranarayanan
Summary: Homochirality is essential for the proper functioning of biomacromolecules in all life forms. DTD enzyme plays a role in maintaining homochirality by removing mistakenly attached D-amino acids during protein synthesis. The activity of DTD is modulated by discriminator base in tRNA, which protects the correct pairing of tRNA.
Article
Biology
Yuya Fukano, Masashi Soga
Summary: This article discusses the formation of entomophobia and its impact on insect conservation from an evolutionary psychological perspective. It suggests that modern humans' negative responses to insects are driven by evolutionary emotional, cognitive, and behavioral traits related to avoiding infectious diseases. The article provides strategic recommendations for mitigating the prevalence of entomophobia and calls for better understanding of how individual-level entomophobia can influence insect conservation.
CURRENT OPINION IN INSECT SCIENCE
(2023)
Article
Biology
DeElegant Robinson, Michael Place, James Hose, Adam Jochem, Audrey P. Gasch
Summary: This study found that individual differences in yeast strains dominate the fitness costs of gene overexpression, with global differences in the consequences of gene overexpression independent of the amplified gene, as well as gene-specific effects dependent on the genetic background. Natural variation in response to gene overexpression could be explained by several models, including strain-specific physiological differences, resource limitations, and regulatory sensitivities.
Article
Microbiology
Bharath Reddy Boya, Prasun Kumar, Jin-Hyung Lee, Jintae Lee
Summary: Tryptophanase encoded by the gene tnaA is a pyridoxal phosphate-dependent enzyme that catalyses the conversion of tryptophan to indole, commonly used as a signalling molecule by microbes. While tnaA is commonly found in various Gram-negative bacteria, it is rare in Gram-positive bacteria and archaea. Its presence in eukaryotes, particularly protozoans and marine organisms, highlights its importance in the animal kingdom. This study documents the distribution and acquisition of tnaA among different taxonomic groups, providing insights into its role among various organisms.
Article
Meteorology & Atmospheric Sciences
Fajin Chen, Chao Huang, Qibin Lao, Shuwen Zhang, Chunqing Chen, Xin Zhou, Xuan Lu, Qingmei Zhu
Summary: The study reveals that the dual isotopes (δD and δO-18) of precipitation in southern China are significantly influenced by typhoon events rather than the East Asian Monsoon. Moisture brought by typhoons from remote oceans during typhoon periods can affect precipitation with the lowest δO-18 and D-excess, leading to deviation from the global meteoric water line and the China meteoric water line.
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
(2021)
Article
Plant Sciences
Jiamin Xiao, Rudan Lyu, Jian He, Mingyang Li, Jiaxin Ji, Jin Cheng, Lei Xie
Summary: In this study, the phylogenetic backbone of Clematis was successfully reconstructed using genome skimming and transcriptome data. The nuclear genome data provided a more robust phylogeny compared to plastid data and better corresponded to morphological characters. The results suggested that rapid species radiation and frequent interspecific hybridization events might contribute to the nuclear gene discordance and cyto-nuclear discordances in Clematis.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biology
Richard McFarland, S. Peter Henzi, Andrea Fuller, Robyn S. Hetem, Christopher Young, Louise Barrett
Summary: Most primates, including humans, give birth during the inactive phase of the daily cycle. However, our understanding of the timing of nocturnal birth in wild diurnal primates is limited. This study measured maternal core body temperature during 24 births in wild vervet monkeys and found distinct changes in temperature during the birth process. Vervet monkeys typically give birth during their inactive phase, in sync with the lowest point of the maternal daily temperature rhythm, but individual variations in temperature during birth were observed. These findings suggest that the timing of primate birth may be influenced by the lower night-time temperatures and improve thermal efficiency during birth.
Article
Biotechnology & Applied Microbiology
Na Song, Siyu Ma, Xiang Zhao, Jiabao Zhao, Linlin Zhao
Summary: This study conducted a whole-genome survey analysis of Okamejei kenojei, revealing its genomic characteristics such as genome size, repeat sequence content, and heterozygous ratio. The study also determined the phylogenetic status of Okamejei kenojei and identified potential microsatellite loci. The findings not only provide valuable information for understanding the genome structure and functional characteristics of Okamejei kenojei, but also lay the foundation for future whole-genome mapping.
MARINE BIOTECHNOLOGY
(2023)
Article
Hematology
Amos Tuval, Yardena Brilon, Hadas Azogy, Yoni Moskovitz, Dena Leshkowitz, Tomer M. Salame, Mark D. Minden, Perry Tal, Varda Rotter, Moshe Oren, Nathali Kaushansky, Liran Shlush
Summary: Pre-leukemic clones carrying DNMT3A mutations have inherent chemoresistance and selective advantage. They also have a dominant pseudo-mutant P53 conformation. Shifting the dynamic equilibrium in favor of the wild-type P53 conformation can eliminate dysfunctional cells.
Article
Hematology
Amos Tuval, Yardena Brilon, Hadas Azogy, Yoni Moskovitz, Dena Leshkowitz, Tomer M. Salame, Mark D. Minden, Perry Tal, Varda Rotter, Moshe Oren, Nathali Kaushansky, Liran Shlush
Summary: The study found that pre-leukemic hematopoietic stem/progenitor cells (preL-HSPC) carrying DNMT3A mutations have abnormal P53 conformation, which can be targeted with specific peptide treatment to eliminate the abnormal conformation, providing a new avenue for leukemia prevention.
Article
Ophthalmology
Y Adini, A Wilkonsky, R Haspel, M Tsodyks, D Sagi
