Article
Ophthalmology
Daniel M. Gore, Marcello T. Leucci, Su-yin Koay, Nikolaos Kopsachilis, Michael N. Nicolae, Michail Malandrakis, Vijay Anand, Bruce D. Allan
Summary: The study reported 2-year results of accelerated corneal collagen cross-linking using the Avedro KXL system. The findings suggest that accelerated pulsed CXL is a safe and effective intervention to halt disease progression in progressive keratoconus.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Andreina Tarff, Laura E. Drew-Bear, Rebecca Yee, Marisol Cano, Ying Zhang, Ashley Behrens
Summary: This study compares the efficacy of high UVA irradiance photoactivation of riboflavin with the standard corneal cross-linking protocol on bacterial viability. The results show that high UVA irradiance photoactivation does not seem to be effective for bacterial eradication.
Article
Ophthalmology
Hossein Farrokhpour, Mohammad Soleimani, Kasra Cheraqpour, Ahmad Masoumi, Seyed Ali Tabatabaei, Mansoor Shahriari, Sara Hobaby, Seyed Mahbod Baharnoori, Ahmed Chaudhry, Ali R. Djalilian
Summary: This study presents the 7-year experience of a tertiary eye hospital with standard corneal cross-linking (CXL) and explores the risk factors and incidence of infectious keratitis. The results show that out of 4,863 eyes that underwent CXL, 6 eyes developed infectious keratitis, with an incidence rate of 0.12%. The study emphasizes the importance of proper patient selection, comprehensive medical history, rigorous patient education and follow-up, and aggressive early therapy for patients with suspicious findings.
JOURNAL OF REFRACTIVE SURGERY
(2023)
Article
Ophthalmology
Sally Hayes, Philip Jaycock, Nicholas Rees, Francisco C. Figueiredo, David P. S. O'Brart, Keith M. Meek
Summary: This study aimed to provide insights into the trends in corneal cross-linking (CXL) practice in the UK. Variations were found between UK-based CXL centers in terms of diagnostic evaluation, patient selection, the CXL procedure, and post-operative monitoring.
Review
Pharmacology & Pharmacy
Duoduo Wu, Dawn Ka-Ann Lim, Blanche Xiao Hong Lim, Nathan Wong, Farhad Hafezi, Ray Manotosh, Chris Hong Long Lim
Summary: Corneal cross-linking (CXL) using riboflavin and ultraviolet A (UVA) light is a versatile treatment option for a variety of corneal diseases, including keratoconus. Recent advances include PACK-CXL for infectious keratitis and CurV customized protocols, which have generated increased interest in the field.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Ophthalmology
Abdelrahman Salman, Taym Darwish, Marwan Ghabra, Obeda Kailani, Hussam Khalil, Rafea Shaaban
Summary: Accelerated corneal cross-linking is effective and safe in halting the progression of pediatric keratoconus, with improved visual acuities.
JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hagar Olshaker, Asaf Achiron, Alexander Chorny, Farhad Hafezi, Tal Yahalomi, Assaf Kratz, Erez Tsumi, Nan-Ji Lu, Boris Knyazer
Summary: The study evaluated the efficacy and safety of high fluence PACK-CXL as an adjuvant therapy for infectious keratitis. The results showed that high fluence PACK-CXL is safe and efficient in promoting re-epithelization time and reducing the need for keratoplasties.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Shuyi Liu, Shifeng Fang, Lijun Zhang
Summary: Adjuvant PACK-CXL treatment can accelerate the healing of fungal keratitis. However, more rigorous randomized controlled trials are needed to determine its clinical efficacy and safety.
SYSTEMATIC REVIEWS
(2023)
Article
Ophthalmology
Shira Hed, Ran Matlov Kormas, Sagi Shashar, Boris E. Malyugin, Matthew Boyko, Boris Knyazer
Summary: This study compared the outcomes of standard and accelerated CXL in pediatric population with keratoconus, finding no significant differences in visual acuity, keratometry, and tomographic parameters between the two protocols. The results suggest that accelerated CXL is as safe and effective as standard CXL for stabilizing progressive keratoconus in children.
JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Ozlem Barut Selver, Dilek Yesim Metin, Suleyha Hilmioglu Polat, Aylin Dogen, Melis Palamar
Summary: This study aims to report a case of fungal keratitis with perforation after corneal collagen cross-linking (CXL) treatment for keratoconus. The patient had undergone bilateral CXL procedure 4 days prior and presented with redness and discharge in the left eye. The corneal melting with surrounding infiltrates was observed, and microbiological assessment was performed.
Article
Ophthalmology
Pauline Khoo, Maria Cabrera-Aguas, Stephanie L. Watson
Summary: This study retrospectively reported the clinical profile and microbiology of patients with microbial keratitis post accelerated corneal collagen cross-linking. The results showed that post-CXL microbial keratitis was predominantly associated with gram-positive bacteria and in some cases delayed epithelial healing, leading to moderate to poor patient outcomes.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Denise Wajnsztajn, Or Shmueli, Ken Zur, Joseph Frucht-Pery, Abraham Solomon
Summary: This study evaluated predictors for success in corneal crosslinking (CXL) for keratoconus. The results showed that CXL was more successful in eyes with high Kmax(pre), high SEpre, and high LogMAR(pre). The non-accelerated epithelium-off protocol resulted in greater flattening of corneal curvature, but had similar effects on visual acuity compared to other protocols.
Article
Medicine, General & Internal
Zhennan Zhao, Xueli Chen, Yi Shao, Tingting Shao
Summary: This study compared the antifungal efficacy of corneal cross-linking (CXL) and voriconazole in experimental Aspergillus keratitis models. The results showed that combined therapy with voriconazole and CXL effectively reduced ulcer area and depth, shortened the duration of hyphae, and accelerated corneal repair.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Eren Aytekin, Sibel Bozdag Pehlivan
Summary: Current treatment approaches for keratoconus include options such as penetrating keratoplasty, deep anterior lamellar keratoplasty, and corneal collagen cross-linking. Early diagnosis and halting the disease with CXL methods are becoming crucial in clinical practice.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Ophthalmology
Riccardo Vinciguerra, Giovanni Fossati, Tania Sorrentino, Emanuela F. Legrottaglie, Raffaele Piscopo, Pietro Rosetta, Paolo Vinciguerra
Summary: The study evaluated the long-term efficacy and safety of corneal cross-linking in patients with keratoconus over the age of 40. The results showed that S-CXL was able to safely stop the progression of keratoconus and induce significant flattening of the cone, making it a safe and effective treatment option for progressive keratoconus even in older patients.
JOURNAL OF REFRACTIVE SURGERY
(2021)