Article
Medicine, Research & Experimental
Jiahui Huang, Chenxing Liu, Shuna Duan, Ji Lin, Yingyi Luo, Shengchang Tao, Shangping Xing, Xiaofeng Zhang, Haiyan Du, Huan Wang, Chunlei Huang, Gang Wei
Summary: Gigantol can inhibit the proliferation of breast cancer cells and enhance cisplatin-induced apoptosis by downregulating the PI3K/Akt/mTOR signaling pathway. The combination of gigantol and cisplatin may offer therapeutic benefits in clinical treatment regimens against breast cancer.
Article
Oncology
Songjia Ni, Jianjun Li, Sujun Qiu, Yingming Xie, Kaiqin Gong, Yang Duan
Summary: The study revealed that KIF21B is upregulated in osteosarcoma and may regulate the proliferation and apoptosis of osteosarcoma cells through the PI3K/AKT pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shengcai Gu, Lei Shu, Lv Zhou, Yuxin Wang, Hanying Xue, Lan Jin, Zhiyu Xia, Xingliang Dai, Peng Gao, Hongwei Cheng
Summary: CALCRL is highly expressed in low-grade gliomas. Interfering with CALCRL expression can inhibit the proliferation of glioma cells and promote apoptosis.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Yue Wang, Chunxia Yang, Wenjing Li, Ying Shen, Jianzhong Deng, Wenbin Lu, Jianhua Jin, Yongping Liu, Qian Liu
Summary: Through bioinformatics analysis, nine potential core genes highly expressed in colon cancer samples were screened out, with NKD1 being one of the hub genes that can enhance the proliferation of colon cancer cells by maintaining beta-catenin stability and mediating its interaction with the Wnt signalosome. This suggests that NKD1 could be a specific colorectal cancer marker different from its role in zebrafish.
Article
Immunology
Ling Yang, Xueyuan Yu, Meng Liu, Yang Cao
Summary: This study used bioinformatics analysis to identify OA markers associated with synovitis and cartilage apoptosis and established a predictive risk score model. The results showed that OA samples could be classified into two subtypes, subtype 1 and subtype 2, with significant differences in expression of characteristic genes. Protein-protein interaction network analysis revealed the impact of certain genes on the IL-17 pathway and tumor necrosis factor pathway. qPCR experiments confirmed the predicted results and provided potential therapeutic targets for future treatments.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pathology
Jinsong Yu, Fengbo Li, Yan Li, Zhong Li, Guangwei Jia, Bo Ding, Yeqi Zhou
Summary: This study identified that hsa_circ_0000517 is upregulated in breast cancer and acts as a sponge of miR-326 to suppress its expression, thereby promoting proliferation, invasion, and inhibiting apoptosis of breast cancer cells. The silencing of hsa_circ_0000517 repressed breast cancer progression by upregulating miR-326 expression.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Multidisciplinary Sciences
Sean M. Gross, Farnaz Mohammadi, Crystal Sanchez-Aguila, Paulina J. Zhan, Tiera A. Liby, Mark A. Dane, Aaron S. Meyer, Laura M. Heiser
Summary: In this study, the authors use genetically engineered breast cancer cell lines and computational models to analyze the effects of drugs on specific cell cycle phases and identify effective combination treatments.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Huan Hou, Ying Xu, Meilin Xie, Rong Chen
Summary: This study aimed to investigate the potential molecular mechanisms of trastuzumab-induced cardiotoxicity. The results showed that trastuzumab may induce cardiotoxicity by activating the CD74/STAT1 signaling pathway, leading to apoptosis and inflammation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jia Hou, Wenyuan Li, Shirong Zhang, Deli Tan, Kejia Lv, Yue Zhu, Yuzhu Hou, Hui Guo, Lili Jiang
Summary: This study found that UHRF1 is overexpressed in small cell lung cancer (SCLC) and its high expression is associated with poor prognosis. Mechanistic studies revealed that UHRF1 promotes SCLC growth by modulating YAP1. Downregulation of UHRF1 enhances sensitivity to platinum-based chemotherapy and is correlated with a favorable prognosis. Therefore, UHRF1 can be used as a biomarker and potential therapeutic target for SCLC.
MOLECULAR CARCINOGENESIS
(2023)
Article
Environmental Sciences
Lingling Jiang, Yinglei Liu, Manhua Liu, Yanli Zheng, Liping Chen, Feng Shan, Jinlong Ji, Yang Cao, Haili Kai, Xinyi Kang
Summary: This study explored the effect of REG3A on ovarian cancer progression. REG3A was found to be over-expressed in OC patients and cells, and associated with poor prognosis. REG3A knockdown inhibited proliferation and cisplatin resistance, induced cell cycle arrest and apoptosis of OC cells. Activation of the PI3K/Akt signaling pathway was identified as the mechanism through which REG3A promotes proliferation and cisplatin resistance in OC cells.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Xia-Hui Lin, Dan-Ying Zhang, Zhi-Yong Liu, Wen-qing Tang, Rong-Xin Chen, Dong-ping Li, Shuqiang Weng, Ling Dong
Summary: The lncRNA-AC079061.1/VIPR1 axis was identified as a novel biomarker that inhibited the proliferation and invasion of hepatocellular carcinoma, affecting the ultimate disease outcome.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Bowen Fu, You Li, Xiaobo Shi, Peng Liu, Yiman Zhang, Hongyan Tian
Summary: This study investigates new therapeutic targets for idiopathic pulmonary arterial hypertension (IPAH) using bioinformatics. Through the analysis of differentially expressed genes and functional validation, a potential target gene, NCAPG, was identified. Animal model and in vitro experiments confirmed the association of NCAPG with the development of IPAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yue Zhang, Hongdong Huang, Wenhu Liu, Sha Liu, Xue Yan Wang, Zong Li Diao, Ai Hua Zhang, Wang Guo, Xue Han, Xiaoqun Dong, Oleksandr Katilov
Summary: miR-21-5p regulates the role of endothelial progenitor cells-derived exosomes in sepsis-induced acute kidney injury through downregulation of RUNX1 expression. Upregulation of miR-21-5p improved renal function and reduced inflammation, while EPCs-exos showed similar effects in this process.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Xinyuan Yu, Weiwei Chen, Jinjie Zhang, Xinfu Gao, Qidi Cui, Zheng Song, Jing Du, Wenwen Lv
Summary: This study finds that Cucurbitacin B (CuB) exhibits anti-tumor activity against lung cancer by inhibiting cell proliferation and invasion, and promoting apoptosis. It may be related to modulation of the hedgehog pathway and p53-related genes at RNA and protein level.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jiasheng Lei, Shuoshuo Ma, Wanliang Sun, Dongdong Wang, Zheng Lu, Dengyong Zhang
Summary: In this study, the researchers found that H2AFY is highly expressed in liver cancer cells and tissues. H2AFY promotes the proliferation and clone formation of liver cancer cells, but has no significant effects on cell migration and invasion. The study suggests that H2AFY could be a potential target for liver cancer therapy.
Article
Materials Science, Multidisciplinary
Fang Wang, Xue-Mei Luo, Li-Ming Lei, Xin Fu, Bin Zhang, Guang-Ping Zhang
Summary: This study estimated the strengthening abilities and barrier strength of the alpha/beta lamellar interfaces and coarse primary/fine secondary alpha lamellae interfaces in Ti alloys based on the lattice and modulus mismatches. The results showed that the alpha/beta lamellar interfaces had higher strengthening abilities and interface barrier strength compared to the coarse primary/fine secondary alpha lamellae interfaces. The study also observed a variation trend in the interface strengthening abilities with the fraction of alpha/beta interfaces, providing a potential strategy for enhancing the strength or deformability of lamellar Ti alloys through manipulating interface properties.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
H. Y. Wan, W. K. Yang, L. Y. Wang, Z. J. Zhou, C. P. Li, G. F. Chen, L. M. Lei, G. P. Zhang
Summary: The study investigated tensile and fatigue properties of selective laser melted Inconel 718 specimens with different thicknesses, revealing the impact of specimen thickness to microstructure unit size ratio on premature necking. A probabilistic statistical model for fatigue limit prediction was proposed, and a standard of t/d >= 4 was recommended for miniature specimen evaluation.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Ji-Peng Zou, Xue-Mei Luo, Bin Zhang, Yan-Wen Luo, Hong-Lei Chen, Fei Liang, Guang-Ping Zhang
Summary: The study found that adding Al can improve the fatigue resistance of CoCrFeMnNi-based high-entropy alloy thin foils, reduce cyclic strain localization, and delay the propagation of fatigue cracks.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Materials Science, Multidisciplinary
L. R. Zeng, L. M. Lei, X. M. Luo, G. P. Zhang
Summary: The dwell fatigue effect poses a threat to the long-term reliability of fan blades and fan disks in aircraft engines. The study examined the fatigue properties of bimodal Ti-6Al-4V alloys with different volume fractions of the primary alpha phase, and found that both pure fatigue and dwell fatigue life decreased with increasing alpha phase volume fraction. The dwell loading induced damage to the alpha phase and reduced fatigue life.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Fu-Lai Cheng, Wen-Ke Yang, Xue-Mei Luo, Guang-Ping Zhang
Summary: The effects of specimen dimensions on the mechanical properties of current collector foils were investigated. Wider specimens and shorter gauge lengths tended to have higher total elongation. A widely cited formula and a new probabilistic model were proposed to describe the geometrical size-dependent elongation.
JOURNAL OF MATERIALS RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Y. C. Wang, L. Y. Wang, B. Zhang, Z. M. Song, X. M. Luo, G. P. Zhang
Summary: This study investigates the building height-dependent creep properties and microstructures of laser powder bed fusion-fabricated Inconel 718 superalloy. The results reveal significant differences in recrystallization degree among specimens taken from different building heights due to variations in dislocation density and texture intensity along the building direction. The bottom specimen exhibits the highest recrystallization degree and longest creep life, attributed to lower dislocation density, higher Taylor factor, and lower grain boundary volume fraction.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Nanoscience & Nanotechnology
Tao Ma, Guang-Ping Zhang, Ping Tan, Bin Zhang
Summary: The effect of homogenization temperature on the creep performance of laser powder bed fusion-fabricated Inconel 718 at 650 degrees was investigated. The results showed that the specimens homogenized at 1100 degrees for 1 hour followed by double-aging treatment exhibited the best creep performance. The basic mechanism for small punch creep was elucidated, and a feasible homogenization strategy for further improving the creep performance was proposed.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Chemistry, Physical
Mei-Yue Li, Bin Zhang, Zhu-Man Song, Xue-Mei Luo, Guang-Ping Zhang
Summary: In this study, the evolution of a local strain of the Ti-6Al-4V alloy under tensile loading was investigated using digital image correlation technique. The results showed the formation of local strain concentration areas and the constant strain compatibility of grains in the macroscopic region. Furthermore, the deformation process was divided into six parts based on the development of the maximum strain gradient, and the strain compatibility of each stage was summarized and analyzed, revealing that primary alpha grains undertook the main deformation at the micro-scale.
Article
Materials Science, Multidisciplinary
F. Wang, L. M. Lei, X. Fu, L. Shi, X. M. Luo, Z. M. Song, G. P. Zhang
Summary: The fatigue crack growth behavior of TA19 alloy and its heat-treated samples was investigated. The crack growth resistance in different regimes was determined by analyzing the interaction between the fatigue crack and alpha/beta phase interface, columnar prior-beta grain boundary, and colony boundary. The results showed that the crack propagation threshold and resistance increased with the increase of lamellar alpha(p) phase and colony width in the near-threshold regime. In the Paris regime, the fatigue cracking path could be deflected at colony boundaries or columnar prior-beta grain boundaries, and the deflection angle influenced the crack growth rate.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Jian-Zhi Chen, Bin Zhang, Zhu-Man Song, Guang-Ping Zhang
Summary: The biaxial tension-torsion in-phase fatigue properties of a welded joint and base material of an A588 steel train bogie were compared. The relation between equivalent stress amplitude and cyclic fatigue life was determined. Results show that the welded joint specimen has a higher fatigue life than the base material at higher stress amplitudes, but the two become closer at lower stress amplitudes. A critical stress range of 368 MPa to 396 MPa dominates the fatigue damage behavior of the welded joint. When stress amplitude exceeds the critical stress, fatigue crack initiation tends to occur at the boundary between the base material and heat-affected zone, while cracks originate from the weld metal zone under lower stress amplitudes. Comprehensive analysis of microstructure and residual stress distribution provides insights for optimizing fatigue performance of welded metallic components.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2023)
Article
Nanoscience & Nanotechnology
Mei-Yue Li, Zhe-Xuan Wang, Bin Zhang, Fei Liang, Xue-Mei Luo, Guang-Ping Zhang
Summary: This study investigated the fatigue strength of nanocrystalline Ni/Ni-W laminated composites. The results showed that the fatigue resistance of the Ni/Ni-W laminated composites was improved compared to monotonic Ni. Shear banding and voiding were identified as the two dominant modes of fatigue damage in the composites. A deformation map was proposed to explain the critical conditions and transition of shear bands and voids. The introduction of ultrathin Ni-W layers hindered crack propagation across the heterogeneous interface, leading to improved fatigue strength.
SCRIPTA MATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Zhe-Xuan Wang, Fei Liang, Guang-Ping Zhang, Bin Zhang
Summary: This study successfully fabricated Ni/Ni-W laminated composites with different monolayer thicknesses and investigated their microstructure stability and tensile properties at 400 degrees C. The annealed Ni0.5/Ni-W0.05 laminated composites exhibited high yield strength and excellent elongation to failure at 400 degrees C, surpassing the monotonic Ni material. The high strength of the laminated composites at high temperatures is attributed to the intrinsic strength of the Ni-W layers, the thickness-constrained effect on grain growth of Ni layers, and the interface coupling effect of heterogeneous structures. The plasticity of the composites can be derived from the heterogeneous laminated structure and the decrease in the constituent layer thickness, providing good co-deformation ability.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Physical
Bing-Li Hu, Yan-Wen Luo, Bin Zhang, Guang-Ping Zhang
Summary: Fatigue life prediction of Inconel 718 fabricated by laser powder bed fusion was investigated using a miniature specimen tests method and machine learning algorithms. Among the thirteen popular machine learning algorithms investigated, the adaptive boosting algorithm exhibited the best fitting accuracy, followed by the decision tree algorithm. These results demonstrate the capability of using small dataset-based machine learning techniques to predict fatigue life.
Article
Nanoscience & Nanotechnology
Yao-Yao Bai, Bin Zhang, Xu-Ping Wu, Xue-Mei Luo, Guang-Ping Zhang
Summary: To address the trade-off between high sensitivity and wide sensing range, researchers developed a flexible pressure sensor with a mass-gradient distribution of Cu onto a textile coated with Ti3C2T x nanosheets. This sensor achieved both high sensitivity and wide sensing range by continuously changing the contact area and conductivity of the contact points under compressive loading. It also demonstrated excellent cycling stability, fast response/recovery time, and breathability, enabling wide applications in monitoring human physiological signals, transmitting encrypted information, and distinguishing pressure distribution in real time.
ACS APPLIED NANO MATERIALS
(2023)
Article
Engineering, Electrical & Electronic
Si-Qi Wang, Bin Zhang, Rong-Hao Qiao, Yan-Wen Luo, Xue-Mei Luo, Guang-Ping Zhang
Summary: Researchers have successfully fabricated a competitive reaction-driven MnO2 nanorod network on a nickel substrate, exhibiting high electroactivity and large strain. This material shows great potential in low-voltage electrochemical actuators for implantable medical devices.
ACS APPLIED ELECTRONIC MATERIALS
(2023)
