期刊
EXPERT REVIEW OF VACCINES
卷 18, 期 5, 页码 457-474出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14760584.2019.1605906
关键词
Epstein-Barr virus; prophylactic vaccines; therapeutic vaccines; immunotherapies; infectious mononucleosis; nasopharyngeal carcinoma; post-transplant lymphoproliferative disorder
类别
资金
- National Health and Medical Research Council (NHMRC) Australia
Introduction: Epstein-Barr virus (EBV) infects more than 95% of the world's population and is associated with infectious mononucleosis as well as a number of cancers in various geographical locations. Despite its significant health burden, no licenced prophylactic or therapeutic vaccines are available.Areas covered: Over the last two decades, our understanding of the role of EBV infection in the pathogenesis and immune regulation of EBV-associated diseases has provided new lines of research to conceptualize various novel prophylactic and therapeutic approaches to control EBV-associated disease. In this review, we evaluate the prophylactic and therapeutic vaccine approaches against EBV and various immunotherapeutic strategies against a number of EBV-associated malignancies. This review also describes the existing and future prospects of improved EBV-targeted therapeutic strategies.Expert opinion: It is anticipated that these emerging strategies will provide answers for the major challenges in EBV vaccine development and help improve the efficacy of novel therapeutic strategies.
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