Article
Neurosciences
Maria Bonsignore
Summary: Obstructive sleep apnoea (OSA) is a common disease associated with increased cardiovascular risk and comorbidities. Various pathophysiological traits are involved, including upper airway collapsibility, upper airway muscle activity, and autonomic imbalance. OSA causes chronic intermittent hypoxia, inflammation, and sympathetic hyperactivity. Clinical studies by the European Sleep Apnoea Database (ESADA) Study Group have explored the relationship between intermittent hypoxia and comorbidities, but more research is needed to understand the clinical implications and adaptive responses to intermittent hypoxia.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Neurosciences
Andrew E. Beaudin, Patrick J. Hanly, Jill K. Raneri, Magdy Younes, Matiram Pun, Todd J. Anderson, Marc J. Poulin
Summary: Exposure to intermittent hypoxia (IH) is believed to increase the risk of cerebrovascular and cardiovascular disease, but sleep accompanied by IH does not significantly alter vascular responses to hypoxia and hypercapnia in healthy young individuals. However, IH sleep does lead to an increased heart rate response to hypoxia upon waking.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Physiology
Bolival A. Mendonca-Junior, Marcos Fernandes, Daniel B. Zoccal
Summary: The study revealed that exposure to acute intermittent hypoxia in rats results in a prolonged increase in baseline minute ventilation and the occurrence of active expiration, potentially linked to the activation of serotonin receptors.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Review
Neurosciences
Nanduri R. Prabhakar, Ying-Jie Peng, Jayasri Nanduri
Summary: Carotid bodies are important sensory organs that detect changes in arterial blood oxygen concentration, and they play a key role in regulating the sympathetic tone, blood pressure, and breathing. This review discusses the effects of intermittent hypoxia on the carotid bodies, including its role in increased sympathetic tone and hypertension, as well as the underlying cellular, molecular, and epigenetic mechanisms. The review also presents evidence for the contribution of a hypersensitive carotid body to obstructive sleep apnoea (OSA) and potential therapeutic interventions for OSA in a murine model.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Physiology
Ana C. Takakura, Milene R. Malheiros-Lima, Thiago S. Moreira
Summary: This study reviews the new advances in active expiration by engaging abdominal muscles and modulation of the parafacial respiratory (pF) region. The lateral aspect of pF (pFL) is distinct from the chemosensitive neurons of the ventral aspect of pFV, suggesting a complex network for the generation of active expiration. The activity of pFL is tonically inhibited by inhibitory inputs and receives excitatory inputs from chemoreceptors and catecholaminergic C1 neurons, indicating a need for further investigation into the modulatory inputs and physiological conditions under which these mechanisms are utilized for increasing ventilation through active expiration.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Critical Care Medicine
Gino S. Panza, Shipra Puri, Ho-Sheng Lin, M. Safwan Badr, Jason H. Mateika
Summary: Daily exposure to mild intermittent hypoxia (MIH) shows beneficial cardiovascular and autonomic outcomes in males with obstructive sleep apnea (OSA) and concurrent hypertension. This study demonstrates that after 15 days of MIH treatment, participants experienced a reduction in blood pressure, accompanied by increased parasympathetic activity and decreased sympathetic activity.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Clinical Neurology
Marlusa Karlen-Amarante, I. P. Isabela, Pedro L. Katayama, Eduardo Colombari, Paloma G. Bittencourt-Silva, Miguel F. Menezes, D. B. Zoccal
Summary: Exposure to postnatal chronic intermittent hypoxia (pCIH) increases the risk of developing cardiorespiratory diseases in adulthood. This study found that pCIH led to elevated arterial pressure levels and increased sympathetic-mediated variability in early adult life. The excessive sympathetic activity persisted until adulthood and contributed to the development of high blood pressure and variability, increasing the risk of cardiovascular diseases.
Article
Peripheral Vascular Disease
David C. Andrade, Camilo Toledo, Hugo S. Diaz, Katherin Pereyra, Karla G. Schwarz, Esteban Diaz-Jara, Claudia Melipillan, Angelica P. Rios-Gallardo, Atenea Uribe-Ojeda, Julio Alcayaga, Rodrigo A. Quintanilla, Rodrigo Iturriaga, Jean-Paul Richalet, Nicolas Voituron, Rodrigo Del Rio
Summary: The study demonstrated that cEpo treatment significantly reduced the carotid body chemoreflex and hypertension induced by CIH, and normalized breathing patterns. This suggests a potential therapeutic application of cEpo in treating cardiorespiratory disorders associated with CIH.
JOURNAL OF HYPERTENSION
(2021)
Article
Physiology
Gauthier Ganouna-Cohen, Francois Marcouiller, Aida Bairam, Vincent Joseph
Summary: We aimed to investigate the impact of low testosterone levels on breathing regulation in mice exposed to intermittent hypoxia (IH). We used orchiectomized (ORX) or control (Sham-operated) mice and exposed them to normoxia or IH. After measuring breathing stability and the frequency and duration of apneas, we found that IH increased the occurrence of apneas and the proportion of certain types of sighs. The effects were more pronounced in ORX-IH mice, suggesting that testosterone plays a role in breathing regulation following IH.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nariman Battulin, Vladimir M. Kovalzon, Alexey Korablev, Irina Serova, Oxana O. Kiryukhina, Marta G. Pechkova, Kirill A. Bogotskoy, Olga S. Tarasova, Yuri Panchin
Summary: The discovery of the Pannexin protein family in vertebrates, particularly the PANX1 gene, suggests its importance in biological functions, including infertility and oocyte development defects in humans. However, studies on Panx1 knockout mice show mild phenotypes, raising questions about its specific functions. Further research is necessary to reevaluate the pathological role of the Arg217His substitution in Panx1 and its general functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Rachel E. Stirling, Cindy M. Hidajat, David B. Grayden, Wendyl J. D'Souza, Jodie Naim-Feil, Katrina L. Dell, Logan D. Schneider, Ewan Nurse, Dean Freestone, Mark J. Cook, Philippa J. Karoly
Summary: Bed and wake times are more crucial than sleep duration in identifying seizure risk for people with epilepsy. Undersleeping is associated with a slight decrease in seizure risk, possibly due to nocturnal seizures. Wearables can be used to analyze sleep-seizure relationships and provide clinical recommendations.
Review
Anesthesiology
Anthony G. Doufas, Toby N. Weingarten
Summary: Pharmacologically induced ventilatory depression is a common postoperative complication with varying levels of severity, potentially leading to serious consequences. Recent studies have shown high rates of previously undetected episodes of postoperative ventilatory depression, making recognition challenging and hindering better understanding of its epidemiology. The effects of drugs, patient factors, and the complex nature of ventilatory control all play roles in the recovery of ventilation after surgery and anesthesia.
ANESTHESIA AND ANALGESIA
(2021)
Review
Neurosciences
Tommy Sutor, Kathryn Cavka, Alicia K. Vose, Joseph F. Welch, Paul Davenport, David D. Fuller, Gordon S. Mitchell, Emily J. Fox
Summary: The study found that a single session of acute intermittent hypoxia (AIH) can increase maximal inspiratory pressure generation in adults with chronic spinal cord injury (SCI), but does not affect other breathing functions. Further investigation into the potential therapeutic effects is warranted.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Anabel L. Castro-Grattoni, Monique Suarez-Giron, Ivan Benitez, Lourdes Tecchia, Marta Torres, Isaac Almendros, Ramon Farre, Adriano Targa, Josep M. Montserrat, Mireia Dalmases, Ferran Barbe, David Gozal, Manuel Sanchez-de-la-Torre
Summary: The study found that the impact of CIH on gene expression is organ-dependent and influenced by age. In young mice, CIH increased the expression of genes related to cardiac protection and cell survival, while this effect was not as significant in old mice. In aortic tissue, CIH reduced the expression of genes related to antioxidant response in both young and old mice, indicating vascular oxidative stress and an aging-promoting process.
Article
Oncology
Elena Diaz-Garcia, Sara Garcia-Tovar, Raquel Casitas, Ana Jaureguizar, Ester Zamarron, Begona Sanchez-Sanchez, Ana Sastre-Perona, Eduardo Lopez-Collazo, Francisco Garcia-Rio, Carolina Cubillos-Zapata
Summary: The study shows that patients with obstructive sleep apnea (OSA) exhibit elevated levels of PSPC1, which is cleaved from monocytes by MMP2 and released into the plasma. Intermittent hypoxia (IH) promotes the expression of PSPC1, TGF beta, and MMP2 in monocytes, leading to increased expression of genes driving epithelial-to-mesenchymal transition. These findings suggest a mechanism by which hypoxemia contributes to tumor progression and aggressiveness in OSA patients.
Article
Obstetrics & Gynecology
Domitila A. Huber, Darlan Bazilio, Flaviano Lorenzon, Sibele Sehnem, Lucas Pacheco, Janete A. Anselmo-Franci, Fernanda B. Lima
REPRODUCTIVE SCIENCES
(2018)
Letter
Physiology
Darlan S. Bazilio, Davi J. A. Moraes, Benedito H. Machado
EXPERIMENTAL PHYSIOLOGY
(2020)
Article
Physiology
Karla L. Rodrigues, Juliana R. Souza, Darlan S. Bazilio, Mauro de Oliveira, Melina P. S. Moraes, Davi J. A. Moraes, Benedito H. Machado
Summary: The study found that mice exposed to sustained hypoxia exhibit changes in autonomic and respiratory activity, making them an important model for studying the modulation of sympathetic activity to the cardiovascular system and vagal innervation to the upper airways.
EXPERIMENTAL PHYSIOLOGY
(2021)