Article
Environmental Sciences
Lei Zhang, Jiming Zhang, Yiming Dai, Shenliang Lv, Zheng Wang, Sinan Xu, Dasheng Lu, Xiaojuan Qi, Chao Feng, Weijiu Liang, Hao Xu, Yang Cao, Guoquan Wang, Zhijun Zhou, Chunhua Wu
Summary: This study found a positive correlation between maternal exposure to parabens and cord serum leptin levels, and leptin levels were positively associated with offspring size. Both paraben and adipokine levels may affect fetal growth, and sex-specific differences may exist.
Article
Environmental Sciences
Hakimeh Teiri, Mohammad Reza Samaei, Mansooreh Dehghani, Abooalfazl Azhdarpoor, Yaghoub Hajizadeh, Farzaneh Mohammadi, Roya Kelishadi
Summary: This study examined the association of maternal exposure to benzophenones with gestational age and evaluated their effects on birth outcomes. The results showed that benzophenone derivatives, especially BP-3, can affect the duration of pregnancy and fetal growth, with boys having heavier birth weights than girls. Preterm infants had noticeably lower birth outcomes compared to term infants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Milu Li, Su Zhou, Yaling Wu, Yan Li, Wei Yan, Qingchun Guo, Yueyue Xi, Yingying Chen, Yuanyuan Li, Meng Wu, Jinjin Zhang, Jia Wei, Shixuan Wang
Summary: This study revealed that embryonic exposure to propylparaben (PrP) led to adverse effects on ovarian function in adult mice, including accelerated ovarian aging, decreased follicle pool size, and increased follicular atresia, potentially through oxidative stress, inflammation, and fibrosis pathways.
ENVIRONMENTAL POLLUTION
(2021)
Article
Genetics & Heredity
Ling Yu, Hongling Zhang, Tongzhang Zheng, Juan Liu, Xingjie Fang, Shuting Cao, Wei Xia, Shunqing Xu, Yuanyuan Li
Summary: In this study, the researchers investigated the association between prenatal exposure to phthalates and neurocognitive development in children. They found that exposure to mono-n-butyl phthalate (MnBP) during pregnancy was negatively correlated with children's neurocognitive development. Additionally, they identified a potential genetic modifier, PPAR alpha rs1800246, that could modify the association between MnBP and neurodevelopmental outcomes.
FRONTIERS IN GENETICS
(2022)
Article
Environmental Sciences
Huan Chen, Hongling Zhang, Xin Wang, Yi Wu, Yiqiong Zhang, Silan Chen, Wenxin Zhang, Xiaojie Sun, Tongzhang Zheng, Wei Xia, Shunqing Xu, Yuanyuan Li
Summary: This study found that prenatal arsenic exposure, especially in early pregnancy, was negatively associated with neurodevelopment of children at two years old, even at low exposure levels. This finding is important for understanding the effects of low-level arsenic exposure on child neurodevelopment.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Duo Zhang, Jinqiu Xiao, Qinru Xiao, Yining Chen, Xiangyu Li, Quanzhi Zheng, Jiaojiao Ma, Jiayi Xu, Jinfeng Fu, Junchun Shen, Lehan Xiao, Shaoyou Lu
Summary: This study investigated the levels of common preservatives and antimicrobials in major infant food sources in southern China and found potential health risks associated with the intake of certain additives. It is recommended that breastfeeding women reduce their consumption of personal care products and processed food, especially during the first month after delivery.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Ziga Tkalec, Tina Kosjek, Janja Snoj Tratnik, Anja Stajnko, Agneta Annika Runkel, Marianthi Sykiotou, Darja Mazej, Milena Horvat
Summary: The study in Slovenian children and adolescents revealed exposure to a wide range of different endocrine disrupting chemicals, with variations in levels based on age, gender, and location. Associations were found between exposure levels and factors such as dietary habits, use of food packaging, and personal care products. Additionally, a genetic polymorphism in UGT2B15 gene was linked to levels of methyl and ethyl paraben, indicating a potential biomarker for susceptibility to adverse effects caused by exposure.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Minyan Chen, Yi Hu, Cheng Lv, Rong Shi, Yan Zhang, Weifeng Tang, Xiaodan Yu, Ying Tian, Yu Gao
Summary: This study found that triclosan (TCS) exposure levels decreased as children's age increased in a Chinese birth cohort. TCS exposure at ages 5 and 7 was positively associated with physical growth at age 7, and these associations were only significant in boys.
Article
Environmental Sciences
Tina Kold Jensen, Anna-Maria Andersson, Katharina M. Main, Trine Holm Johannsen, Marianne S. Andersen, Henriette Boye Kyhl, Anders Juul, Hanne Frederiksen
Summary: The study found that maternal exposure to parabens was associated with reproductive hormone levels and anogenital distance in male and female infants, with greater effects observed in girls and inconsistent effects in boys. This suggests potential endocrine-disrupting effects of parabens on human development, particularly in vulnerable periods.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Engineering, Environmental
Zhenzhen Xie, Hong Liang, Maohua Miao, Ziliang Wang, Yao Chen, Lan Yang, Yan Zhou, Wencheng Cao, Wei Yuan
Summary: Prenatal exposure to PFASs is linked to increased attention problems in children, which can be mitigated by higher maternal nut intake.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Jiming Zhang, Zheng Wang, Yiming Dai, Lei Zhang, Jianqiu Guo, Shenliang Lv, Xiaojuan Qi, Dasheng Lu, Weijiu Liang, Yang Cao, Chunhua Wu, Xiuli Chang, Zhijun Zhou
Summary: This study found an association between prenatal triclosan exposure and certain birth outcomes, possibly affecting intrauterine growth by interfering with thyroid-related hormones, gonadal hormones, adipokines, TMAO, and its precursors.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Qiuling Li, Yulong Qiao, Feifei Wang, Jian Zhao, Lijun Wu, Honghua Ge, Shengmin Xu
Summary: Triclosan (TCS), commonly found in personal care and household products, has been recently associated with children's health and gestational TCS exposure. However, its effects on embryonic lung development remain unclear. This study found that prenatal TCS exposure resulted in impaired lung development and altered airway patterning. The dysplasias were accompanied by reduced proliferation and increased apoptosis, mediated by activated Bmp4 signaling. Inhibiting Bmp4 signaling partially rescued the defects. In vivo evidence showed that administering TCS during gestation compromised branching formation and enlarged airspace in the offspring's lungs. This study provides novel toxicological insights into TCS and suggests a strong/possible association between TCS exposure during pregnancy and lung dysplasia in offspring.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Zachariah E. M. Morgan, Maximilian J. Bailey, Diana I. Trifonova, Noopur C. Naik, William B. Patterson, Frederick W. Lurmann, Howard H. Chang, Bradley S. Peterson, Michael I. Goran, Tanya L. Alderete
Summary: This study aimed to explore the relationships between prenatal ambient air pollution exposure and neurodevelopment during infancy. The findings showed that higher prenatal exposure to PM10 and PM2.5 was negatively associated with cognitive, motor, and language development in infants.
ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
Esha Bansal, Hsiao-Hsien Hsu, Erik de Water, Sandra Martinez-Medina, Lourdes Schnaas, Allan C. Just, Megan Horton, David C. Bellinger, Martha M. Tellez-Rojo, Robert O. Wright
Summary: This study found a relationship between prenatal PM2.5 exposure and vigilance and inhibitory control in children, emphasizing the second and third trimesters of gestation as critical windows for PM2.5 exposure.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Xiaohu Ren, Yilan Deng, Wei Liu, Jinfeng Fu, Zhihong Huang, Duo Zhang, Qinru Xiao, Xiangyu Li, Xiao Chen, Xinfeng Huang, Jianjun Liu, Shaoyou Lu
Summary: The potentiality of parabens and triclosan to disrupt the neurological system has raised concerns. A study on elderly individuals found a correlation between these chemicals and cognitive impairment, although not statistically significant. Further investigation with a larger sample size is needed.
Article
Chemistry, Analytical
Lei Guo, Jiyang Dong, Xiangnan Xu, Zhichao Wu, Yinbin Zhang, Yongwei Wang, Pengfei Li, Zhi Tang, Chao Zhao, Zongwei Cai
Summary: Research on metabolic heterogeneity is crucial for understanding the molecular mechanisms of diseases and developing personalized treatments. The use of mass spectrometry imaging (MSI) enables the identification of spatially contiguous or sporadic regions of interest, revealing the heterogeneity of an organism at a molecular level.
ANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Wei Huang, Guodong Cao, Chengliang Deng, Yanyan Chen, Tao Wang, Da Chen, Zongwei Cai
Summary: This study investigated the effects of TCS exposure on kidney function in mice. The results showed that TCS caused renal injury, oxidative stress, inflammation, and fibrosis in a dose-dependent manner. Metabolite analysis revealed lipid accumulation and defective fatty acid metabolism in TCS-exposed mouse kidney, which may contribute to renal function impairment.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Chen Xiao, Kaien Li, Jingmin Hua, Zhao He, Feng Zhang, Qiongfang Li, Hailei Zhang, Lei Yang, Shuying Pan, Zongwei Cai, Zhiling Yu, Kam-Bo Wong, Yiji Xia
Summary: Arabidopsis DXO1 is an essential component in the methylation of the guanosine cap to form the m(7)G cap. It activates RNA guanosine-7 methyltransferase (AtRNMT1) to catalyze this conversion. This study reveals an important mechanism in m(7)G capping in plants and the role of DXO1 in this process.
NATURE COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Chao Zhong, Guorong Li, Wenchang Tian, Dan Ouyang, Yin Ji, Zongwei Cai, Zian Lin
Summary: Enzyme immobilization is crucial for its application in various fields. Covalent organic frameworks (COFs) are ideal for enzyme immobilization due to their controlled porous structures. However, constructing COFs-based enzyme immobilization systems with high activity using existing methods is still challenging.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Peiru Luo, Mengke Bai, Qingyun He, Zifang Peng, Lingyun Wang, Chuan Dong, Zenghua Qi, Wenfen Zhang, Yanhao Zhang, Zongwei Cai
Summary: The widespread use of plastic products has led to a significant release of microplastics (MPs) into the environment. However, the study of MPs in atmospheric fine particulate matter (PM2.5) is limited due to the lack of appropriate analytical methods. This study developed a novel strategy using pyrolysis-gas chromatography-tandem mass spectrometry (Pyr-GC-MS/MS) to accurately quantify polyethylene MPs (PE-MPs) in PM2.5 without sample pretreatment. The results showed relatively serious pollution of PE-MPs in Taiyuan and suggested the widespread occurrence and potential human exposure risks of PM2.5-bound PE-MPs.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Hongli Tan, Liu Yang, Xiaolin Liang, Diedie Huang, Xinhang Qiao, Qingyuan Dai, Da Chen, Zongwei Cai
Summary: With the tightening restrictions on phthalate esters (PAEs), nonphthalate plasticizers (NPPs) are increasingly used. However, there is limited knowledge on the environmental occurrences, fate, and human exposure risks of many emerging NPPs. This study investigated the presence of NPPs and major PAEs in house dust, finding widespread occurrences of NPPs, such as ATBC, TCTM, TOTM, GMO, MO, and DiBA. Although current exposure may not pose significant health risks, potential hazards cannot be overlooked due to the lack of toxic threshold data and possible cocktail effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Editorial Material
Engineering, Environmental
Guodong Cao, Zongwei Cai
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Xiaojian Shao, Hailei Zhang, Zhou Zhu, Fenfen Ji, Zhao He, Zhu Yang, Yiji Xia, Zongwei Cai
Summary: The recent discovery of noncanonical RNA caps, such as NAD(+) and dpCoA, has expanded our understanding of RNA caps. To identify and characterize dpCoA-RNAs, a method called dpCoA tagSeq was developed. This method efficiently tags and captures dpCoA-capped RNAs, allowing for further functional investigations.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Jing Chen, Peisi Xie, Pengfei Wu, Zian Lin, Yu He, Zongwei Cai
Summary: This study used metabolomics and lipidomics combined with mass spectrometry imaging to reveal the mechanisms of enhanced growth of MCF-7 breast cancer cell spheroids exposed to triclosan (TCS). The results showed that TCS and TCS sulfate penetrated the entire area of the cell spheroids initially, but localized in the inner area later. Metabolomics data indicated that TCS exposure induced alterations in energy metabolism and the biosynthesis of glycerophospholipids and glycerolipids. Mass spectrometry imaging revealed enhanced energy supply in the peripheral area and increased energy storage in the inner area as potential contributors to the enhanced growth of MCF-7 breast cancer cell spheroids exposed to TCS.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Xuemei Wang, Chin Wai Leung, Zongwei Cai, Di Hu
Summary: Organophosphate flame retardants (OPFRs) were found in PM2.5 in Hong Kong, with chlorinated OPFRs being the dominant component. Plastic processing and waste disposal were identified as the main emission sources. Health risk assessment revealed a low-risk level for PM2.5-bound OPFRs, but relatively high noncarcinogenic and carcinogenic risks were associated with chlorinated OPFRs emitted from plastic processing and waste disposal.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Guodong Cao, Wei Wang, Jing Zhang, Pengfei Wu, Han Qiao, Huankai Li, Gefei Huang, Zhu Yang, Zongwei Cai
Summary: para-Phenylenediamine quinones (PPD-Qs) are newly discovered transformation products derived from para-phenylenediamine (PPD) antioxidants. Their occurrence and fate in wastewater treatment plants (WWTPs) need further investigation to improve pollutant removal efficiency.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Jie-Ru Jiang, Zhi-Feng Chen, Xiao-Liang Liao, Qian-Yi Liu, Jia-Ming Zhou, Shi-Ping Ou, Zongwei Cai
Summary: Tire wear particles (TWPs) are increasingly present in water, but little is known about their environmental consequences. In this study, TWP leachates were analyzed to identify potentially toxic organic substances using high-resolution mass spectrometry and toxicity identification. Thirteen substances were structurally identified, with cyclic amines found to be toxic to the tested algal species. Metabolomic analysis revealed differential metabolites associated with linoleic acid and purine metabolism, and oxidative stress was identified as a key factor in algal growth inhibition. This study highlights the risk posed by TWP leachable substances to aquatic organisms.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Environmental
Yanshan Liang, Leiguang Li, Hongna Zhang, Qingyuan Dai, Guangshan Xie, Bo Lei, Zhu Yang, Zongwei Cai
Summary: Triclosan can cause thyroid damage and disrupt the synthesis and release of thyroid hormones, leading to hypothyroidism.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Xiaoou Wei, Jiang Yu, Yong Tian, Yujie Ben, Zongwei Cai, Chunmiao Zheng
Summary: Accurately predicting influent wastewater quality is crucial for the efficient operation and maintenance of wastewater treatment plants. This study evaluated three machine learning models and successfully applied them to three full-scale WWTPs in Shenzhen, China. The study provides a model framework for forecasting wastewater loads and sets the groundwork for smart management.
Article
Chemistry, Analytical
Jiajing Chen, Huan Huang, Dan Ouyang, Jiali Lin, Zhuling Chen, Zongwei Cai, Zian Lin
Summary: Analysis of cis-diol compounds is crucial due to their important roles in various fields. Researchers have developed a matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS) method to effectively analyse cis-diol compounds. This method utilizes a unique reactive matrix (BMQI) for in situ derivatization of cis-diol compounds, resulting in improved speed, reproducibility, and signal intensity, as well as reduced background interference. Additionally, the method has been successfully applied to the rapid screening and identification of sugar alcohols in different sugar-free foods.