期刊
ENDOCRINE REVIEWS
卷 40, 期 4, 页码 1152-1162出版社
ENDOCRINE SOC
DOI: 10.1210/er.2019-00004
关键词
-
资金
- Swiss National Fund [31003A-170029/1]
- Fondation pour la lutte contre le cancer et pour des recherches medico-biologiques
- Fondation romande pour la recherche pour le diabete
- Novo Nordisk
- Swiss National Science Foundation (SNF) [31003A_170029] Funding Source: Swiss National Science Foundation (SNF)
Sex steroid estrogens, androgens, and progesterone, produced by the gonads, which have long been considered as endocrine glands, are implicated in sexual differentiation, puberty, and reproduction. However, the impact of sex hormones goes beyond these effects through their role on energy metabolism. Indeed, sex hormones are important physiological regulators of glucose homeostasis and, in particular, of the enteroinsular axis. In this review, we describe the roles of estrogens, androgens, and progesterone on glucose homeostasis through their effects on pancreatic a-and b-cells, as well as on enteroendocrine L-cells, and their implications in hormonal biosynthesis and secretion. The analysis of their mechanisms of action with the dissection of the receptors implicated in the several protective effects could provide some new aspects of the fine-tuning of hormonal secretion under the influence of the sex. This knowledge paves the way to the understanding of transgender physiology and new potential therapeutics in the field of type 2 diabetes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据