Article
Environmental Sciences
Ved Prakash, Veena Jain, Shweta Singh Chauhan, Ramakrishnan Parthasarathi, Somendu K. Roy, Sadasivam Anbumani
Summary: The study evaluated the developmental toxicity of 4-MBC in zebrafish embryos and larvae, revealing significant delays in hatching rate, heart rate, length, and motility. Additionally, chronic exposure resulted in decreased SOD activity and increased GST enzyme levels, indicating differential oxidative stress during development stages.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Kimberly A. Jarema, Deborah L. Hunter, Bridgett N. Hill, Jeanene K. Olin, Katy N. Britton, Matthew R. Waalkes, Stephanie Padilla
Summary: This study evaluated the developmental toxicity and behavioral effects of 61 chemicals in zebrafish larvae, finding that approximately half of the chemicals showed no gross developmental toxicity at the highest concentration tested. Some chemicals were toxic only at higher concentrations, while 11 chemicals caused behavioral effects, with four altering behavior in the absence of developmental toxicity.
Article
Genetics & Heredity
Roman A. Li, Marja Talikka, Sylvain Gubian, Colette vom Berg, Florian Martin, Manuel C. Peitsch, Julia Hoeng, Anze Zupanic
Summary: Adverse outcomes from chemical toxicity are often caused by system-level perturbations in molecular event networks rather than individual protein dysregulation. Understanding toxicity mechanisms requires recognizing interactions of molecules, pathways, and biological processes within these networks. The developing brain, a highly complex network, presents challenges in developmental neurotoxicity, which can be addressed through the use of systems toxicology methods like computable biological networks.
FRONTIERS IN GENETICS
(2021)
Article
Environmental Sciences
Zhihui Liu, Yingying Shangguan, Penglin Zhu, Yousef Sultan, Yiyi Feng, Xiaoyu Li, Junguo Ma
Summary: Glyphosate exposure in zebrafish larvae induces developmental toxicity, characterized by premature hatching, reduced heartbeats, and body deformities. This is likely due to disrupted thyroid function and abnormal expression of growth hormone/insulin-like growth factor axis-related genes. Additionally, glyphosate treatment leads to oxidative damage, endoplasmic reticulum stress, inflammatory reactions, and apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Jenna Wiegand, Vanessa Cheng, Aalekhya Reddam, Sarah Avila-Barnard, David C. Volz
Summary: This study found that TPHP causes pericardial edema and a significant increase in ionocyte abundance in zebrafish embryos. Mannitol can block these effects, while knockdown of ATPase1a1.4 can only mitigate the increase in ionocyte abundance and ouabain can only enhance the occurrence of pericardial edema.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jong-Su Park, Palas Samanta, Sangwoo Lee, Jieon Lee, Jae-Woo Cho, Hang-Suk Chun, Seokjoo Yoon, Woo-Keun Kim
Summary: Acrylamide induces neurotoxicity and developmental toxicity in zebrafish, leading to various developmental abnormalities and impaired locomotor behavior. The zebrafish model offers a rapid and cost-efficient approach to studying acrylamide neurotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Cong M. Tran, Hyojin Lee, Byoungcheun Lee, Jin-Sung Ra, Ki-Tae Kim
Summary: This study compared the developmental toxicities of six major OPEs in chorionated and dechorionated zebrafish embryos using a fixed exposure scheme. Removal of the chorion increased sensitivity to OPEs, leading to higher incidence of mortality and malformation. Behaviorally, zebrafish larvae exhibited inhibited locomotive activity by OPEs regardless of chorion presence. At the molecular level, the presence of the chorion influenced the expression of certain genes in zebrafish embryos exposed to specific OPEs.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Hojun Lee, Garam An, Junho Park, Whasun Lim, Gwonhwa Song
Summary: This study demonstrates the toxic effects of molinate on zebrafish larvae, including reduced viability and successful hatching, and the induction of apoptosis, inflammation, and endoplasmic reticulum stress response. Additionally, molinate exposure leads to abnormal cardiovascular, neuronal, and liver development in zebrafish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Marine & Freshwater Biology
Nadine Kaemmer, Lothar Erdinger, Thomas Braunbeck
Summary: The study investigates the sensitivity of zebrafish to neurotoxic substances and the impact of swim bladder deflation on respiratory failure syndrome. The results show that post-embryonic 12-day-old larvae are more sensitive than embryos and adult fish, with higher accumulation of substances in 4-day-old fish, and swim bladder deflation may contribute to oxygen deprivation in respiratory failure syndrome.
AQUATIC TOXICOLOGY
(2022)
Article
Marine & Freshwater Biology
Bangeppagari Manjunatha, B. Deekshitha, Eunseok Seo, Jeongju Kim, Sang Joon Lee
Summary: Research shows that exposure to PM2.5 leads to increased mortality, reduced hatching rates, lower heart rates, and various developmental abnormalities in zebrafish. It also causes damage in skin cell layers, abnormalities in neurons, heart, liver, gills, brain, and eyes, and increased organelle dissolution at cellular/subcellular levels. Further investigation is needed to understand the specific elements in diesel pollution that contribute to this toxicity.
AQUATIC TOXICOLOGY
(2021)
Article
Marine & Freshwater Biology
Xiaoqin Niu, Shengnan Xu, Qiongying Yang, Xuelian Xu, Miaomiao Zheng, Xi Li, Wanchun Guan
Summary: The study found that K. mikimotoi does not affect the survival rate of larvae, but significantly decreases their locomotion and enzyme activity. In addition, it was observed that K. mikimotoi only decreased locomotion at night in a day-night behavioral experiment.
Review
Environmental Sciences
Juanmei Gao, Wanhua Shen
Summary: The Xenopus model is advantageous for studying embryo development and developmental toxicity, as well as human diseases. It has been successfully used to study various diseases, including fetal alcohol spectrum disorders, autism, epilepsy, and cardiovascular disease. Xenopus also has potential applications in genetic and chemical screening.
ENVIRONMENTAL POLLUTION
(2021)
Review
Biochemistry & Molecular Biology
Alessio Filippo Peritore, Enrico Gugliandolo, Salvatore Cuzzocrea, Rosalia Crupi, Domenico Britti
Summary: Perfluorinated and polyfluorinated alkyl substances (PFAS), numbering more than 4700, are persistent chemicals that accumulate in living organisms and the environment. Due to their extensive use, PFAS are globally present, presenting concerns for animals, humans, and the environment. They can have various adverse health effects, and dietary intake is the most significant source of exposure. The review analyzes the characteristics, uses, and environmental presence of PFAS, highlighting the toxic potential, exposure, and related mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Yi Liu, Jing Guo, Wenjin Liu, Fengjie Yang, Yunyun Deng, Yunlong Meng, Bo Cheng, Jianping Fu, June Zhang, Xinjun Liao, Lili Wei, Huiqiang Lu
Summary: Pesticides, such as haloxyfop-p-methyl, are harmful to the aquatic ecosystem as they leave residues in soil, water, and agricultural products. This study investigated the toxic effects of haloxyfop-p-methyl on zebrafish and found developmental, neurotoxic, and immunotoxic effects. Zebrafish larvae exhibited spinal deformities, decreased body length, slow heart rate, and enlarged yolk sac area. Behavior analysis showed reduced activity, accompanied by higher AChE activity. Exposure to haloxyfop-p-methyl also induced oxidative stress and affected immune cell populations in the thymus. Furthermore, haloxyfop-p-methyl caused neutrophil apoptosis and increased expression of proinflammatory cytokine genes. These findings provide insights into the toxicological mechanisms of haloxyfop-p-methyl in teleosts.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Environmental Sciences
Yang Xu, Jihyun Jang, Myung Chan Gye
Summary: The contamination of phthalate ester plasticizers poses a threat to wildlife and human health. This study evaluated the developmental toxicity and cellular stress-inducing potential of commonly used phthalate esters and emerging alternatives. The results showed that these plasticizers had varying effects on animal development and cellular stress at different concentrations.
ENVIRONMENTAL POLLUTION
(2022)
Article
Engineering, Environmental
Leah M. Thornton, Elise M. Path, Gunnar S. Nystrom, Barney J. Venables, Marlo K. Sellin Jeffries
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2016)
Article
Environmental Sciences
Leah M. Thornton, Elise M. Path, Barney J. Venables, Marlo K. Sellin Jeffries
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2016)
Article
Environmental Sciences
Alexandra T. Yost, Leah M. Thornton, Barney J. Venables, Marlo K. Sellin Jeffries
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2016)
Article
Fisheries
Leah M. Thornton, Meriel C. LeSueur, Alexandra T. Yost, Dane A. Stephens, James T. Oris, Marlo K. Sellin Jeffries
FISH & SHELLFISH IMMUNOLOGY
(2017)
Article
Environmental Sciences
Kyle S. Roush, Julie C. Krzykwa, Jacob A. Malmquist, Dane A. Stephens, Marlo K. Sellin Jeffries
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2018)
Article
Environmental Sciences
Julie C. Krzykwa, Alexis Olivas, Marlo K. Sellin Jeffries
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2018)
Article
Fisheries
Leah M. Thornton, Elise M. Path, Gunnar S. Nystrom, Barney J. Venables, Mario K. Sellin Jeffries
FISH & SHELLFISH IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Steven E. Fiester, Brock A. Arivett, Robert E. Schmidt, Amber C. Beckett, Tomislav Ticak, Mary V. Carrier, Rajarshi Ghosh, Emily J. Ohneck, Maeva L. Metz, Marlo K. Sellin Jeffries, Luis A. Actis
Article
Environmental Sciences
Teresa J. Norberg-King, Michelle R. Embry, Scott E. Belanger, Thomas Braunbeck, Joshua D. Butler, Phil B. Dorn, Brianna Farr, Patrick D. Guiney, Sarah A. Hughes, Marlo Jeffries, Romain Journel, Marc Leonard, Mark McMaster, James T. Oris, Kathy Ryder, Helmut Segner, Thomas Senac, Glen Van Der Kraak, Graham Whale, Peter Wilson
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2018)
Article
Environmental Sciences
Kyle S. Roush, Marlo K. Sellin Jeffries
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2019)
Article
Environmental Sciences
Julie C. Krzykwa, Marlo K. Sellin Jeffries
Article
Fisheries
Leah M. Thornton Hampton, Christopher J. Martyniuk, Barney J. Venables, Marlo K. Sellin Jeffries
FISH & SHELLFISH IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Julie C. Krzykwa, Marlo K. Jeffries
Article
Multidisciplinary Sciences
Leah M. Thornton Hampton, Marlo K. Sellin Jeffries, Barney J. Venables