期刊
DIGESTIVE DISEASES AND SCIENCES
卷 64, 期 10, 页码 2823-2829出版社
SPRINGER
DOI: 10.1007/s10620-019-05626-2
关键词
miR-9-5p; Gastric cancer; Migration; 3 ' UTR
资金
- Youth Research Project of Health and Family Planning Commission of Fujian Province, China [2015-2-48]
- Natural Science Foundation of Guangdong Province, China [2018A0303130302]
- Medical Research Fund of Guangdong Province, China [A2018011]
- Science Foundation for The Excellent Youth Scholars of Jinan University, China [89018021, 21618302]
Background MicroRNA is essential for the malignant progression of human gastric cancer (GC), which is a leading cause of cancer deaths. However, the mechanism is still not so clear. Aims In our present research, we investigated the effect of miR-9-5p in GC. Methods We detected miR-9-5p expression in human gastric epithelial cell (GES-1) and GC cells (AGS, BGC-823, MKN-45, and MGC-803), plasma of normal or GC patients, as well as orthotopic xenograft mouse models by real-time PCR. The migration ability was detected by Transwell assays after miR-9-5p mimic or inhibitor transfection in GC cells. Results Our results showed that miR-9-5p expression in GC cells and plasma was significantly decreased. miR-9-5p inhibited migration of GC cells by regulating TNFAIP8L3 directly. Low expression of miR-9-5p in GC patients hardly suppressed the migration mediated by TNFAIP8L3. Conclusions miR-9-5p, as a potential tumor suppressor gene, is closely related to the malignant progression of GC. Exploring the regulation between miR-9-5p and TNFAIP8L3 may provide a novel strategy for GC treatment.
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