期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 99, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2019.103396
关键词
Porcine immune system; B cell receptors; Gene rearrangement; Lymphocyte repertoire development; Lymphocyte subpopulations; Thymus
资金
- Czech Science Foundation (Grantova agentura Ceske republiky, Czech Republic) [16-09296S]
- [RVO 61388971]
Porcine thymus contains three independent populations of cells that have rearranged immunoglobulin heavy chain VDJ(H) genes. The first population can be found exclusively in medulla and it consists of existing mature B cells and plasma cells. The second consists of developing B cells characterized by the presence of selected VDJ(H )rearrangement, similar to B cell lymphogenesis in the bone marrow. The third population is entirely unaffected by selection mechanism for productive VDJ(H )rearrangement and represents T lineage cells that rearrange immunoglobulin genes. Transcription of unselected VDJ(H) repertoire is not allowed in T cells. Sequence analysis of unselected VDJ(H) repertoire from T cells also revealed important consequences for B cell lymphogenesis and selection of B cell repertoire. As far as we know, this is the first evidence that some species completely rearrange VDJ(H )genes in T cells. Our results also support the finding that B cells actively develop in the thymus.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据