Identifying the Transcriptome Signatures of Calcium Channel Blockers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay

(2019) Timon Seeger et al.   CIRCULATION

Determining the Pathogenicity of a Genomic Variant of Uncertain Significance Using CRISPR/Cas9 and Human-Induced Pluripotent Stem Cells

(2018) Ning Ma et al.   CIRCULATION

Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond

(2018) Chun Liu et al.   DEVELOPMENT

Use of human induced pluripotent stem cell–derived cardiomyocytes to assess drug cardiotoxicity

(2018) Arun Sharma et al.   Nature Protocols

Trends in the market for antihypertensive drugs

(2017) M. Adam Ali et al.   NATURE REVIEWS DRUG DISCOVERY

Discovery and Development of Calcium Channel Blockers

(2017) Théophile Godfraind   Frontiers in Pharmacology

Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro

(2016) Elena Matsa et al.   Cell Stem Cell

Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

(2016) Paul W Burridge et al.   NATURE MEDICINE

Induced pluripotent stem cells: at the heart of cardiovascular precision medicine

(2016) Ian Y. Chen et al.   Nature Reviews Cardiology

Myocardial Hypertrophic Preconditioning Attenuates Cardiomyocyte Hypertrophy and Slows Progression to Heart Failure Through Upregulation of S100A8/A9

(2015) X. Wei et al.   CIRCULATION

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Insights Into Molecular, Cellular, and Functional Phenotypes

(2015) I. Karakikes et al.   CIRCULATION RESEARCH

Signaling in Muscle Contraction

(2015) Ivana Y. Kuo et al.   Cold Spring Harbor Perspectives in Biology

Human-induced pluripotent stem cell models of inherited cardiomyopathies

(2014) Ioannis Karakikes et al.   CURRENT OPINION IN CARDIOLOGY

Chemically defined generation of human cardiomyocytes

(2014) Paul W Burridge et al.   NATURE METHODS

L-type calcium channel targeting and local signalling in cardiac myocytes

(2013) Robin M. Shaw et al.   CARDIOVASCULAR RESEARCH

Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells

(2013) Feng Lan et al.   Cell Stem Cell

Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity

(2013) Ping Liang et al.   CIRCULATION

Pharmacogenomic Association of Nonsynonymous SNPs in SIGLEC12 , A1BG , and the Selectin Region and Cardiovascular Outcomes

(2013) Caitrin W. McDonough et al.   HYPERTENSION

Dilated cardiomyopathy: the complexity of a diverse genetic architecture

(2013) Ray E. Hershberger et al.   Nature Reviews Cardiology

The effect of microgrooved culture substrates on calcium cycling of cardiac myocytes derived from human induced pluripotent stem cells

(2012) Christopher Rao et al.   BIOMATERIALS

High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents

(2011) Junyi Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Decreased cardiac L-type Ca2+ channel activity induces hypertrophy and heart failure in mice

(2011) Sanjeewa A. Goonasekera et al.   JOURNAL OF CLINICAL INVESTIGATION

Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

(2011) Masayuki Yazawa et al.   NATURE

Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy

(2010) Xiongwen Chen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Physical and Functional Interaction Between Calcineurin and the Cardiac L-Type Ca 2+ Channel

(2009) Samvit Tandan et al.   CIRCULATION RESEARCH

CACNA1C Gene Polymorphisms, Cardiovascular Disease Outcomes, and Treatment Response

(2009) Amber L. Beitelshees et al.   Circulation-Cardiovascular Genetics

S100A8 and S100A9 Mediate Endotoxin-Induced Cardiomyocyte Dysfunction via the Receptor for Advanced Glycation End Products

(2008) John H. Boyd et al.   CIRCULATION RESEARCH

Calcium Cycling and Signaling in Cardiac Myocytes

(2007) Donald M. Bers   Annual Review of Physiology