ApoB The Power of Physiology to Transform the Prevention of Cardiovascular Disease

Conventional epidemiological methods applied to prospective observational studies and randomized clinical trials have driven our understanding of the factors that increase the risk of cardiovascular disease, as well as the therapies that reduce it. Demonstrating that increased levels of cholesterol were associated with increased cardiovascular risk and that lowering cholesterol reduced cardiovascular risk is one of the preeminent triumphs of modern medical science. But knowledge widens as it deepens and the greater complexity that results can be an unwanted outcome of learning more.