期刊
CHEMSUSCHEM
卷 12, 期 11, 页码 2345-2349出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.201900799
关键词
alcohols; alkylation; borrowing hydrogen; iron catalysis; oxindoles
资金
- School of Chemistry, Cardiff University
- TETFund
- EPSRC [EP/L016443/1]
- EPSRC UK National Mass Spectrometry Facility at Swansea University
A general and efficient iron-catalyzed C-alkylation of oxindoles has been developed. This borrowing hydrogen approach employing a (cyclopentadienone)iron carbonyl complex (2 mol %) exhibited a broad reaction scope, allowing benzylic and simple primary and secondary aliphatic alcohols to be employed as alkylating agents. A variety of oxindoles underwent selective mono-C3-alkylation in good-to-excellent isolated yields (28 examples, 50-92 % yield, 79 % average yield).
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