Stabilizing p ‐Dithiobenzyl Urethane Linkers without Rate‐Limiting Self‐Immolation for Traceless Drug Release

Intracellular Delivery of Native Proteins Facilitated by Cell-Penetrating Poly(disulfide)s

(2018) Linghui Qian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody–Drug Conjugates

(2018) Zhonghua Pei et al.   MOLECULAR PHARMACEUTICS

Towards antibody-drug conjugates and prodrug strategies with extracellular stimuli-responsive drug delivery in the tumor microenvironment for cancer therapy

(2017) Nicolas Joubert et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Delivery and Release of Small-Molecule Probes in Mitochondria Using Traceless Linkers

(2017) Eric K. Lei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates

(2017) Thomas H. Pillow et al.   Chemical Science

Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody–drug conjugates

(2016) Leanna R. Staben et al.   Nature Chemistry

Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody–Drug Conjugates

(2016) Donglu Zhang et al.   ACS Medicinal Chemistry Letters

Disulfide-Based Multifunctional Conjugates for Targeted Theranostic Drug Delivery

(2015) Min Hee Lee et al.   ACCOUNTS OF CHEMICAL RESEARCH

Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing

(2015) Wayne C. Widdison et al.   BIOCONJUGATE CHEMISTRY

An oral redox-sensitive self-immolating prodrug strategy

(2015) Tao Sun et al.   CHEMICAL COMMUNICATIONS

Antibody–Drug Conjugates and Small Molecule–Drug Conjugates: Opportunities and Challenges for the Development of Selective Anticancer Cytotoxic Agents

(2015) Giulio Casi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Orthogonal Cysteine–Penicillamine Disulfide Pairing for Directing the Oxidative Folding of Peptides

(2015) Yiwu Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Noninternalizing Targeted Cytotoxics for Cancer Therapy

(2015) Giulio Casi et al.   MOLECULAR PHARMACEUTICS

Recent Advances in the Development of New Auristatins: Structural Modifications and Application in Antibody Drug Conjugates

(2015) Andreas Maderna et al.   MOLECULAR PHARMACEUTICS

Bio-reduction of Redox-Sensitive Albumin Conjugates in FcRn-Expressing Cells

(2014) Lorine Brülisauer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Curative Properties of Noninternalizing Antibody-Drug Conjugates Based on Maytansinoids

(2014) E. Perrino et al.   CANCER RESEARCH

Disulfide-containing parenteral delivery systems and their redox-biological fate

(2014) Lorine Brülisauer et al.   JOURNAL OF CONTROLLED RELEASE

Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation

(2013) Ron M. Versteegen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Broad Control of Disulfide Stability through Microenvironmental Effects and Analysis in Complex Redox Environments

(2013) Chuanliu Wu et al.   BIOMACROMOLECULES

Gemcitabine–Coumarin–Biotin Conjugates: A Target Specific Theranostic Anticancer Prodrug

(2013) Sukhendu Maiti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering Folate–Drug Conjugates to Target Cancer: From Chemistry to Clinic

(2012) Iontcho R. Vlahov et al.   BIOCONJUGATE CHEMISTRY

A Traceless Vascular-Targeting Antibody-Drug Conjugate for Cancer Therapy

(2011) Gonçalo J. L. Bernardes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design of Antibody−Maytansinoid Conjugates Allows for Efficient Detoxification via Liver Metabolism

(2011) Xiuxia Sun et al.   BIOCONJUGATE CHEMISTRY

Disulfide-Linked Antibody−Maytansinoid Conjugates: Optimization of In Vivo Activity by Varying the Steric Hindrance at Carbon Atoms Adjacent to the Disulfide Linkage

(2011) Brenda A. Kellogg et al.   BIOCONJUGATE CHEMISTRY

Interplay of Chemical Microenvironment and Redox Environment on Thiol-Disulfide Exchange Kinetics

(2011) Chuanliu Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Clinical Pharmacokinetics and Exposure-Toxicity Relationship of a Folate-VincaAlkaloid Conjugate EC145 in Cancer Patients

(2009) Jing Li et al.   JOURNAL OF CLINICAL PHARMACOLOGY