期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 25, 期 37, 页码 8681-8685出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201901046
关键词
allenes; allenylic alkylation; amino acids; asymmetric catalysis; synergistic catalysis
资金
- NSFC [21525207, 21772147]
An unprecedented asymmetric allenylic alkylation of readily available imine esters, which was enabled by a synergistic Cu/Pd catalysis, has been developed. This dual catalytic system possesses good substrate compatibility, delivering a diverse array of nonproteinogenic alpha-allenylic alpha-mono- or alpha,alpha-disubstituted alpha-amino acids (alpha-AAs) with high yields and generally excellent enantioselectivities. Furthermore, the scalability and practicability of the current synthetic protocol were proven by performing gram-scale reactions and by the first catalytic asymmetric synthesis of naturally occurring (S)-gamma-allenic alpha-amino acid, respectively.
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