期刊
CHEMICO-BIOLOGICAL INTERACTIONS
卷 302, 期 -, 页码 156-163出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2019.01.037
关键词
Radix Paeoniae Alba; PGG; HSCCC; Adipogenesis; MAPK; Obesity
资金
- National Natural Science Foundation of China [31571839, 31701712]
- Fundamental Research Funds for the Central Universities [2662018PY058, 2662016QD035]
- Hubei Provincial Natural Science Foundation of China [2017CFB197]
Penta-O-galloyl-beta-D-glucose (PGG) was purified and identified from Radix Paeoniae Alba by HSCCC and HPLC/ESI-MS, and its inhibitory effects on adipogenesis and TNF-alpha-induced inflammation were assessed in 3T3-L1 cell line. The results showed that PGG dose-dependently reduced intracellular lipids accumulation, and this involved decrease the expression levels of major adipogenic markers, PPAR gamma, C/EBP alpha, through MAPKs inhibition. This was accompanied by a reduction of lipogenic genes, ACC, FAS, and SCD-1, involved in fatty acid synthesis. Furthermore, PGG also inhibited TNF-alpha-induced expression of inflammatory cytokines including IL-6 and MCP-1 in the matured 3T3-L1 adipocytes. The inhibitions were likely mediated by blocking the MAPKs and NF-kappa B activation. These findings highlighted that PGG could serve as a potent therapeutic agent for controlling obesity and obesity-related chronic inflammation.
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