Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes

Production, quality control, stability, and potency of cGMP-produced Plasmodium falciparum RH5.1 protein vaccine expressed in Drosophila S2 cells

(2018) Jing Jin et al.   npj Vaccines

Structure of Plasmodium falciparum Rh5–CyRPA–Ripr invasion complex

(2018) Wilson Wong et al.   NATURE

Synergistic malaria vaccine combinations identified by systematic antigen screening

(2017) Leyla Y. Bustamante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P113 is a merozoite surface protein that binds the N terminus of Plasmodium falciparum RH5

(2017) Francis Galaway et al.   Nature Communications

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA

(2017) Lin Chen et al.   eLife

Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody

(2017) Paola Favuzza et al.   eLife

Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development

(2017) Camila Tenorio França et al.   eLife

Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes

(2016) Jennifer C. Volz et al.   Cell Host & Microbe

Proteomic analysis reveals novel proteins associated with thePlasmodiumprotein exporter PTEX and a loss of complex stability upon truncation of the core PTEX component, PTEX150

(2016) Brendan Elsworth et al.   CELLULAR MICROBIOLOGY

Different Regions ofPlasmodium falciparumErythrocyte-Binding Antigen 175 Induce Antibody Responses to Infection of Varied Efficacy

(2016) Chris Y. Chiu et al.   JOURNAL OF INFECTIOUS DISEASES

Implementation of the malaria candidate vaccine RTS,S/AS01

(2016) Brian Greenwood et al.   LANCET

An Antibody Screen of a Plasmodium vivax Antigen Library Identifies Novel Merozoite Proteins Associated with Clinical Protection

(2016) Camila T. França et al.   PLoS Neglected Tropical Diseases

Production of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line system

(2016) Kathryn A. Hjerrild et al.   Scientific Reports

The association between naturally acquired IgG subclass specific antibodies to the PfRH5 invasion complex and protection from Plasmodium falciparum malaria

(2016) Rupert Weaver et al.   Scientific Reports

A PfRH5-Based Vaccine Is Efficacious against Heterologous Strain Blood-Stage Plasmodium falciparum Infection in Aotus Monkeys

(2015) Alexander D. Douglas et al.   Cell Host & Microbe

Multiprotein complex between the GPI-anchored CyRPA with PfRH5 and PfRipr is crucial forPlasmodium falciparumerythrocyte invasion

(2015) K. Sony Reddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paths to a malaria vaccine illuminated by parasite genomics

(2015) David J. Conway   TRENDS IN GENETICS

Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes

(2015) Greta E. Weiss et al.   PLoS Pathogens

The Plasmodium protein P113 supports efficient sporozoite to liver stage conversion in vivo

(2014) Vittoria Offeddu et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies

(2014) Katherine E. Wright et al.   NATURE

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

(2014) Lin Chen et al.   eLife

Bacterially Expressed Full-Length Recombinant Plasmodium falciparum RH5 Protein Binds Erythrocytes and Elicits Potent Strain-Transcending Parasite-Neutralizing Antibodies

(2013) K. Sony Reddy et al.   INFECTION AND IMMUNITY

Neutralization of Plasmodium falciparum Merozoites by Antibodies against PfRH5

(2013) A. D. Douglas et al.   JOURNAL OF IMMUNOLOGY

Assessment of Immune Interference, Antagonism, and Diversion following Human Immunization with Biallelic Blood-Stage Malaria Viral-Vectored Vaccines and Controlled Malaria Infection

(2013) S. C. Elias et al.   JOURNAL OF IMMUNOLOGY

Identification and Prioritization of Merozoite Antigens as Targets of Protective Human Immunity to Plasmodium falciparum Malaria for Vaccine and Biomarker Development

(2013) J. S. Richards et al.   JOURNAL OF IMMUNOLOGY

Naturally Acquired Antibodies Specific for Plasmodium falciparum Reticulocyte-Binding Protein Homologue 5 Inhibit Parasite Growth and Predict Protection From Malaria

(2013) Tuan M. Tran et al.   JOURNAL OF INFECTIOUS DISEASES

Plasmodium falciparum Merozoite Surface Antigen, PfRH5, Elicits Detectable Levels of Invasion-Inhibiting Antibodies in Humans

(2013) Saurabh D. Patel et al.   JOURNAL OF INFECTIOUS DISEASES

Malaria vaccine technology roadmap

(2013) Vasee S Moorthy et al.   LANCET

Vaccination with Conserved Regions of Erythrocyte-Binding Antigens Induces Neutralizing Antibodies against Multiple Strains of Plasmodium falciparum

(2013) Julie Healer et al.   PLoS One

Passive Immunoprotection of Plasmodium falciparum-Infected Mice Designates the CyRPA as Candidate Malaria Vaccine Antigen

(2012) A. M. Dreyer et al.   JOURNAL OF IMMUNOLOGY

A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants

(2012) Leyla Y. Bustamante et al.   VACCINE

Enhancing Blockade of Plasmodium falciparum Erythrocyte Invasion: Assessing Combinations of Antibodies against PfRH5 and Other Merozoite Antigens

(2012) Andrew R. Williams et al.   PLoS Pathogens

Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum

(2011) Cécile Crosnier et al.   NATURE

The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

(2011) Alexander D. Douglas et al.   Nature Communications

An EGF-like Protein Forms a Complex with PfRh5 and Is Required for Invasion of Human Erythrocytes by Plasmodium falciparum

(2011) Lin Chen et al.   PLoS Pathogens

Crystal Structure of the Entire Ectodomain of gp130

(2010) Yibin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reticulocyte-binding protein homologue 5 – An essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum

(2008) Jake Baum et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY