期刊
CELLULAR IMMUNOLOGY
卷 341, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2019.04.009
关键词
IL-17A; Diabetic retinopathy; Retinal pathology
资金
- Research to Prevent Blindness Foundation
- Ohio Lions Eye Research Foundation
- [VA BX003403]
- [RO1 EY022938]
- [R24 EY024864]
- [VA BX002117]
- [P30 EY011373]
Diabetic retinopathy is a prevailing diabetes complication, and one of the leading causes of blindness worldwide. IL-17A is a cytokine involved in the onset of diabetic complications. In the current study, we examined the role of IL-17A in the development of retinal inflammation and long-term vascular pathology in diabetic mice. We found IL-17A expressing T cells and neutrophils in the retinal vasculature. Further, the IL-17A receptor was expressed on Muller glia, retinal endothelial cells, and photoreceptors. Finally, diabetes-mediated retinal inflammation, oxidative stress, and vascular leakage were all significantly lower in IL-17A(-/-) mice. These are all clinically meaningful abnormalities that characterize the onset of diabetic retinopathy.
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