Article
Developmental Biology
Lili Zhou, Anthony R. McAdow, Hunter Yamada, Brooke Burris, Dana Klatt Shaw, Kelsey Oonk, Kenneth D. Poss, Mayssa H. Mokalled
Summary: Unlike mammals, adult zebrafish have the ability to recover from major spinal cord injury. Glial cells in zebrafish play a pro-regenerative role in bridging the injured area, unlike reactive gliosis observed in mammalian spinal cord repair. This study provides insights into the molecular and cellular responses of glial cells after spinal cord injury in adult zebrafish, identifying key regulatory features and cellular progeny involved in innate spinal cord regeneration.
Article
Neuroimaging
Simon Schading, Gergely David, Tim Max Emmenegger, Cristian Achim, Alan Thompson, Nikolaus Weiskopf, Armin Curt, Patrick Freund
Summary: This study tracks the spatiotemporal dynamics of remote anterograde and retrograde spinal tract degeneration in the upper cervical cord following SCI over two years utilizing quantitative MRI. The findings show ongoing structural changes, indicative of myelin reductions and atrophy within 2 years after SCI, providing potential biomarkers for regenerative and remyelinating therapies along entire spinal pathways.
NEUROIMAGE-CLINICAL
(2023)
Article
Cell Biology
Angela D. Morris, Sarah Kucenas
Summary: Injecting lysolecithin into zebrafish larvae allows for visualization of key features of lysolecithin-induced demyelination, similar to mammalian models, providing a new approach to study the temporal dynamics of such damage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Zhihao Zhang, Zhijie Zhu, Xiaoshuang Zuo, Xuankang Wang, Cheng Ju, Zhuowen Liang, Kun Li, Jiawei Zhang, Liang Luo, Yangguang Ma, Zhiwen Song, Xin Li, Penghui Li, Huilin Quan, Peipei Huang, Zhou Yao, Ning Yang, Jie Zhou, Zhenzhen Kou, Beiyu Chen, Tan Ding, Zhe Wang, Xueyu Hu
Summary: This study investigated the mechanisms of photobiomodulation (PBM) in relieving neuropathic pain (NP) after spinal cord injury (SCI). It was found that PBM therapy inhibited the activation of microglia and astrocytes, decreased the expression of CXCL10 in glial cells, and mediated the NF-κB signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Developmental Biology
Maria Micaela Sartoretti, Carla A. Campetella, Guillermo M. Lanuza
Summary: This study demonstrates that a restricted pool of progenitors in the mouse spinal cord produces a subset of astrocytes with extraordinary precision. The progenitor transcriptional programs highly influence glial fate and are instrumental in creating astrocyte diversity.
Article
Biochemistry & Molecular Biology
Malgorzata Zawadzka, Marine Yeghiazaryan, Sylwia Niedziolka, Krzysztof Miazga, Anna Kwasniewska, Marek Bekisz, Urszula Slawinska
Summary: Enhanced remyelination plays an important role in the recovery of motor and sensory functions in spinal cord injuries. The injection of ethidium bromide induced multifocal demyelination, leading to increased oligodendrocyte progenitor cells after 14 days. In double-EB-injected rats, most axons were remyelinated by Schwann cells and went beyond the injury epicenter into distant spinal cord segments, while some serotoninergic fibers grew caudally through the injury site. Behavioral tests confirmed significant improvement in locomotor function recovery, which was impaired by the blockade of serotonin receptors, emphasizing the important role of restored serotonergic fibers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Nicole Pukos, Christina M. Marion, W. David Arnold, Benjamin T. Noble, Phillip G. Popovich, Dana M. McTigue
Summary: Our previous study found that a large number of new oligodendrocytes (OLs) are generated in the injured spinal cord of mice, with peak oligodendrogenesis occurring between 4 and 7 weeks post-injury. We also observed new myelin formation up to 2 months post-injury. Our current research expands on these findings, quantifying new myelin formation up to 6 months post-injury and investigating indices of demyelination. We discovered that remyelination reaches its peak during the third month post-injury and continues for at least 6 months. Additionally, we observed chronic demyelination through the expression of Nav1.2 and nodal protein disorganization. Our study also revealed a potential mechanism for initiating post-injury myelination, showing that oligodendrocyte progenitor cells (OPCs) make contact with glutamatergic axons in an activity-dependent manner. Increasing OPC/axon contacts through chemogenetic activation of axons may serve as a therapeutic target for enhancing post-spinal cord injury myelin repair.
Article
Pharmacology & Pharmacy
Yingqiao Li, Zhiru Zou, Jinyu An, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu
Summary: This study developed chitosan-modified hollow manganese dioxide nanoparticles for the delivery of resveratrol to treat spinal cord injury. The nanoparticles successfully reduced oxidative stress, inflammation, and neuronal apoptosis in vitro and in vivo experiments.
Review
Biochemistry & Molecular Biology
Anna Smaling, Lorenzo Romero-Ramirez, Jorg Mey
Summary: Bile acids have both metabolic and signaling functions, acting through a bile acid receptor TGR5. TUDCA, a bile acid, has been tested in animal models of spinal cord injury and showed cytoprotective effects. However, the evidence does not support its use as a treatment for SCI.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Cell Biology
Shuxin Liu, Wei Zhang, Lin Yang, Fan Zhou, Peng Liu, Yaping Wang
Summary: The study showed that BMP7 has neuroprotective effects on rats with SCI, reducing demyelination and promoting functional recovery. BMP7 partially reversed oligodendrocyte loss, helping to maintain the normal structure of myelin, increase the number of axons, and improve scores. The protective effects of BMP7 may involve the induction of p-Smad1/5/9 and p-STAT3 in oligodendrocytes.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Engineering, Biomedical
Xue Jiang, Xiaoyao Liu, Qi Yu, Wenwen Shen, Xifan Mei, He Tian, Chao Wu
Summary: This study aimed to design plasma complex component functionalized manganese-doped silica nanoparticles as a targeted drug carrier for resveratrol. The results showed that this drug delivery system effectively reduced oxidative stress, inflammation, and neuronal apoptosis in spinal cord tissue after spinal cord injury, promoting motor function recovery in mice.
MATERIALS TODAY BIO
(2022)
Article
Neurosciences
Sitong Yang, Jingjing Ma, Han Zhang, Laiqiang Chen, Yuxuan Li, Mingtian Pan, Hongcheng Zhu, Jun Liang, Dajian He, Shihua Li, Xiao-Jiang Li, Xiangyu Guo
Summary: Huntington's disease (HD) is characterized by late-onset neurodegeneration caused by expanded CAG repeats in the huntingtin gene (HTT). This study investigated whether mutant HTT affects the development of glial cells during early brain development. The results showed that the numbers of astrocytes and oligodendrocytes in postnatal HD KI mice were not significantly altered compared to wild type (WT) mice, but myelin protein expression was reduced at 3 months of age. These findings suggest that cytoplasmic mutant HTT mediates myelination defects in the early stages of HD without impacting glial cell differentiation and maturation.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Miho Shiratori-Hayashi, Makoto Tsuda
Summary: Glial cells, particularly astrocytes, have been found to play a significant role in modulating itch processing in the nervous system. Their activation in response to skin inflammation contributes to the exacerbation of chronic itch. Studies have highlighted the importance of glial cells in the pathogenesis and progression of neurological diseases.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2021)
Article
Biochemistry & Molecular Biology
Xueting Li, Ce Chen, Mingyue He, Lidong Yu, Renhao Liu, Chunmeng Ma, Yu Zhang, Jianbo Jia, Bingsheng Li, Li Li
Summary: Lead is an important raw material for industrial production, but it poses serious harm to aquatic ecosystems, especially causing spinal malformations in zebrafish embryos, which is mainly attributed to Pb2+-induced endoplasmic reticulum stress and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jiantao Huo, Feng Du, Kaifang Duan, Guangjuan Yin, Xi Liu, Quan Ma, Dong Dong, Mengge Sun, Mei Hao, Dongmei Su, Tianwen Huang, Jin Ke, Shishi Lai, Zhi Zhang, Chao Guo, Yuanjie Sun, Longzhen Cheng
Summary: Research shows that brain-to-spinal circuits involving Oprm1 neurons in the lateral parabrachial nucleus (lPBNOprm1) and Pdyn neurons in the dorsal medial regions of hypothalamus (dmHPdyn) play a role in preventing contralateral mechanical allodynia and reducing the duration of bilateral mechanical allodynia induced by capsaicin. Inhibiting or deleting these neurons, or blocking spinal k-opioid receptors, leads to long-lasting bilateral mechanical allodynia. Conversely, activating dmHPdyn neurons or their axonal terminals in the spinal dorsal horn can suppress sustained bilateral mechanical allodynia induced by lPBN lesion.
Article
Immunology
A. Soto-Dominguez, C. Davila-Martinez, U. Castillo-Velazquez, A. M. Nevarez-Garza, H. Rodriguez-Rocha, O. Saucedo-Cardenas, A. Y. Arce Mendoza, J. J. Zarate-Ramos, L. E. Rodriguez-Tovar
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2020)
Article
Immunology
Carolina E. Luna-Rodriguez, Rogelio De J. Trevino-Rangel, Adolfo Soto-Dominguez, Miguel A. Becerril-Garcia, Martin A. Gonzalez-Montalvo, Andrea M. Saldivar, Humberto Rodriguez-Rocha, Gloria M. Gonzalez
MICROBIAL PATHOGENESIS
(2020)
Article
Biotechnology & Applied Microbiology
R. Garcia-Garza, D. Salas-Trevino, F. A. Soto-Patino, E. A. Gonzalez-Murillo, E. E. Castelan-Maldonado, O. Saucedo-Cardenas, V. J. Romero-Diaz, S. E. Velazquez-Gauna, A. Soto-Dominguez
Summary: The study compared the effects of conventional histological technique (CT) and rapid acetone dehydration technique (AT) on the morphology and staining properties of human organ biopsies, showing that AT preserved tissue morphology and staining properties as effectively as CT. Therefore, the rapid AT procedure is a promising alternative technique for tissue processing.
BIOTECHNIC & HISTOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
C. Davila-Martinez, U. Castillo-Velazquez, A. Soto-Dominguez, A. M. Nevarez-Garza, A. Y. Arce-Mendoza, G. Hernandez-Vidal, D. E. Zamora-Avila, L. E. Rodriguez-Tovar
Article
Cell Biology
Paulina Alejandra Flores de los Rios, Adolfo Soto Dominguez, Ruben Daniel Arellano-Perez Vertti, Edmundo Erbey Castelan Maldonado, Sergio Everardo Velazquez Gauna, Javier Moran Martinez, Daniel Salas Trevino, Ruben Garcia Garza
Article
Agriculture, Dairy & Animal Science
Yaritza Moreno-Mendoza, Karla Denisse Lopez-Villarreal, Carlos Alberto Hernandez-Martinez, Luis Edgar Rodriguez-Tovar, Ana Cecilia Hernandez-Coronado, Adolfo Soto-Dominguez, Michael E. Hume, Gerardo Mendez-Zamora
Summary: The study found that adding 15 g/kg of moringa leaf powder and agave inulin did not affect the performance of Ross 308 broilers but improved intestinal morphology and meat yield.
Article
Veterinary Sciences
Itzel Y. Rangel-Sanchez, Daniel Salas-Trevino, Adolfo Soto-Dominguez, Oscar Garza-Rodriguez, Odila Saucedo-Cardenas, Pablo Zapata-Benavides, Juan J. Zarate-Ramos, Sibilina Cedillo-Rosales, Diana E. Zamora-Avila
ACTA VETERINARIA HUNGARICA
(2020)
Article
Plant Sciences
Gloria A. Guillen-Melendez, Sheila A. Villa-Cedillo, Raymundo A. Perez-Hernandez, Uziel Castillo-Velazquez, Daniel Salas-Trevino, Odila Saucedo-Cardenas, Roberto Montes-de-Oca-Luna, Christian A. Gomez-Tristan, Aime Jazmin Garza-Arredondo, Diana Elisa Zamora-Avila, Maria de Jesus Loera-Arias, Adolfo Soto-Dominguez
Summary: The study demonstrated the cytotoxic effects of Acalypha monostachya extracts on human tumor cell lines, showing potential antineoplastic effects. The extracts induced morphological changes in tumor cells, with the methanolic and hexane extracts exhibiting stronger cytotoxic effects.
Article
Plant Sciences
Gloria A. Guillen-Melendez, Adolfo Soto-Dominguez, Maria de Jesus Loera-Arias, Uziel Castillo-Velazquez, Sheila A. Villa-Cedillo, Edgar Pina-Mendoza, Eduardo Estrada-Castillon, Abelardo Chavez-Montes, Alfredo Gonzalez-Alcocer, Eduardo M. Becerra-Verdin, Alfonso Castaneda-Martinez, Raymundo A. Perez-Hernandez, Daniel Salas-Trevino
Summary: The methanolic extract of Mimosa malacophylla from northern Mexico showed antiurolithic activity, no cytotoxicity to kidney cells, and effective treatment in a murine model of induced urolithiasis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Toxicology
Adolfo Soto-Dominguez, Daniel Salas-Trevino, Gloria A. Guillen-Melendez, Uziel Castillo-Velazquez, Raquel G. Ballesteros-Elizondo, Carlos R. Montes-de-Oca-Saucedo, Sheila A. Villa-Cedillo, Rodolfo Morales-Avalos, Luis E. Rodriguez-Tovar, Roberto Montes-de-Oca-Luna, Odila Saucedo-Cardenas
Summary: This study demonstrates the induction of apoptosis by Peroxiosomicine A1 (PA1) in the kidney and lung in vivo. The morphological, ultrastructural, and biochemical changes associated with apoptosis were observed in mice intoxicated with a toxic dose of PA1. These findings provide valuable insights into the mechanism of action of PA1 at toxic doses in vivo.
Article
Chemistry, Medicinal
Adriana G. Quiroz-Reyes, Paulina Delgado-Gonzalez, Jose F. Islas, Adolfo Soto-Dominguez, Carlos A. Gonzalez-Villarreal, Gerardo R. Padilla-Rivas, Elsa N. Garza-Trevino
Summary: This study evaluated the cytotoxic and proapoptotic activity of soluble TRAIL overexpressed by mesenchymal stem cells (MSC) in an oxaliplatin-resistant CRC cell line. The results demonstrated that oxaliplatin can enhance the apoptotic activity induced by soluble TRAIL.
Article
Medicine, Research & Experimental
Gustavo Villarreal-Reyna, Rodolfo Garza-Morales, Adolfo Soto-Dominguez, Lorena Montanez-Guerrero, Odila Saucedo-Cardenas, Minerva Gomez-Flores, Jorge Alejandro Ocampo-Garza, Jose Juan Perez-Trujillo, Roberto Montes-de-Oca-Luna
Summary: This study presents the first report on hair repigmentation as a previously undescribed effect of Cerebrolysin treatment. Five elderly patients undergoing Cerebrolysin treatment for neurologic diseases experienced hair repigmentation, which has not been reported before. Analysis of scalp biopsies showed increased melanin and melanocyte marker staining after Cerebrolysin treatment.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Biology
Olivia A. Robles-Rodriuez, Maria J. Loera-Arias, Jose J. Perez-Trujillo, Arnulfo Villanueva-Olivo, Ernesto Picon-Galindo, Laura Villarreal-Martinez, Adolfo Soto-Domiguez, Humberto Rodriguez-Rocha, Aracely Garcia-Garcia, Odila Saucedo-Cadenas, Roberto Montes de Oca-Luna
Article
Oncology
Elsa N. Garza-Trevino, Herminia G. Martinez-Rodriguez, Martha S. Rodriguez-Gonzalez, Paulina Delgado-Gonzalez, Juan F. Gonzalez Guerrero, Irma S. Garcia-Gonzalez, Juan Pablo Flores-Gutierrez, Adolfo Soto-Dominguez, Salvador Said-Fernandez
Article
Anatomy & Morphology
Victor Emanuel Rodriguez-Rodriguez, Alejandro Quiroga-Garza, Carlos Saul Rodriguez-Roque, Maria de Jesus Loera-Arias, Adolfo Soto-Dominguez, Santos Guzman-Lopez, Jose Felix Vilchez-Cavazos, Roberto Montes-de-Oca-Luna, Rodrigo Enrique Elizondo-Omana
INTERNATIONAL JOURNAL OF MORPHOLOGY
(2019)