Review
Cell Biology
Cangwei Liu, Hao Guo, Ce Shi, Hongchen Sun
Summary: Short root anomaly (SRA) can cause tooth loss and affect patients' health. Dental implants have limitations compared to natural tooth roots, and tissue engineering-mediated root regeneration offers a more natural function. This article reviews the roles of Bone Morphogenetic Proteins (BMPs) in tooth root development and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Daniel Jun-Kit Hu, Jina Yun, Justin Elstrott, Heinrich Jasper
Summary: The study demonstrates that enteroendocrine cells coordinate stem cell migration towards sites of injury in the Drosophila intestine by activating non-canonical Wnt signaling. This coordination is crucial for efficient tissue repair during injury.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Gloria Pascual, Diana Dominguez, Marc Elosua-Bayes, Felipe Beckedorff, Carmelo Laudanna, Claudia Bigas, Delphine Douillet, Carolina Greco, Aikaterini Symeonidi, Inmaculada Hernandez, Sara Ruiz Gil, Neus Prats, Coro Bescos, Ramin Shiekhattar, Moran Amit, Holger Heyn, Ali Shilatifard, Salvador Aznar Benitah
Summary: The study suggests that dietary palmitic acid (PA), but not oleic acid or linoleic acid, may promote metastasis in oral carcinomas and melanoma in mice. The PA-induced prometastatic memory requires the fatty acid transporter CD36 and is associated with stable deposition of histone H3 lysine 4 trimethylation by methyltransferase Set1A. Furthermore, the proregenerative state of tumor-activated Schwann cells induced by PA may play a role in long-term stimulation of metastasis.
Article
Biochemistry & Molecular Biology
Mahekta R. Gujar, Yang Gao, Xiang Teng, Wei Yung Ding, Jiaen Lin, Ye Sing Tan, Liang Yuh Chew, Yusuke Toyama, Hongyan Wang
Summary: The ability of stem cells to switch between quiescent and proliferative states is crucial for maintaining tissue homeostasis and regeneration. In this study, researchers found that the microtubule minus-end binding protein Patronin/CAMSAP promotes acentrosomal microtubule growth and quiescent neural stem cell (qNSC) reactivation. This is achieved through its interaction with Arf1 and its involvement in microtubule regulation.
Article
Cell Biology
Anthony M. Pettinato, Dasom Yoo, Jennifer VanOudenhove, Yu-Sheng Chen, Rachel Cohn, Feria A. Ladha, Xiulan Yang, Ketan Thakar, Robert Romano, Nicolas Legere, Emily Meredith, Paul Robson, Michael Regnier, Justin L. Cotney, Charles E. Murry, J. Travis Hinson
Summary: Human cardiac regeneration is hindered by low cardiomyocyte replicative rates and polyploidization, with sarcomere assembly, enhanced oxidative metabolism, DNA damage response, and p53 activation playing key roles. Inhibition of sarcomere function or scavenging of ROS can prevent cell-cycle arrest and polyploidization. Increasing troponin-knockout cardiomyocyte proliferation can enhance cardiomyocyte engraftment in infarcted rat hearts.
Article
Agriculture, Multidisciplinary
Hailang Li, Ling Hu, Liwen Wang, Yixuan Wang, Meiqi Shao, Yupei Chen, Wenlin Wu, Lei Wang
Summary: Iron deposition and chronic inflammation are associated with chronic liver diseases. This study found that iron treatment enhances inflammation in HepG2 cells and mice liver, as well as increases the expression of inflammatory cytokines. Additionally, genes involved in iron metabolism and the STING signaling pathway are up-regulated in liver cancer tissues, and patients with high expression of these genes have significantly shortened survival time.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Cell Biology
Cheol Gyu Park, Sang-Hun Choi, Seon Yong Lee, Kiyoung Eun, Min Gi Park, Junseok Jang, Hyeon Ju Jeong, Seong Jin Kim, Sohee Jeong, Kanghun Lee, Hyunggee Kim
Summary: This study reveals a new function of LMO2 in the cytoplasm, where it acts as an activator for the STAT3 signaling pathway in glioma stem cells. The LMO2-LDB1 complex plays a crucial role in the activation of the GSC signaling cascade, and its activity is dependent on interaction with gp130 and JAK1/2.
Article
Multidisciplinary Sciences
Miao Wang, Chuan Lin, Xiaodong Jia, Di Fang, Qinhua Gao, Chunmei Han
Summary: The complete regeneration of deer antlers relies on stem cells proliferation and differentiation. Mesenchymal stem cells of antlers play a crucial role in this process. HGF, synthesized and secreted by mesenchymal cells, binds to c-Met receptor to stimulate cell proliferation and migration, promoting tissue morphogenesis and angiogenesis. However, the role and mechanism of HGF/c-Met signaling pathway on antler MSCs are still unclear.
SCIENTIFIC REPORTS
(2023)
Article
Cell & Tissue Engineering
Qi Liu, Su Pan, Shijie Liu, Sui Zhang, James T. Willerson, James F. Martin, Richard A. F. Dixon
Summary: Targeting the Hippo pathway in muscles can promote angiogenesis and myogenesis, leading to improved functional recovery and increased exercise endurance in ischemic muscles. Knockdown of SAV1 enhances proliferation of muscle satellite cells and endothelial cells, playing a crucial role in skeletal muscle regeneration.
Article
Integrative & Complementary Medicine
Xiaojiao Fan, Jing Chen, Yajun Zhang, Siyi Wang, Wenqian Zhong, Huipu Yuan, Xia Wu, Chaochen Wang, Yixin Zheng, Yuan Wei, Ying Xiao
Summary: This study clarified the mechanism by which Alpinetin (AP) promotes hair regeneration by activating HFSCs via Wnt signaling. These findings may contribute to the development of a new generation of pilatory that is more efficient and less cytotoxic for treating alopecia.
Article
Cell Biology
Yuke Shu, Qing Xu, Yahong Xu, Qing Tao, Mingyang Shao, Xiaoyue Cao, Yuwei Chen, Zhenru Wu, Menglin Chen, Yongjie Zhou, Ping Zhou, Yujun Shi, Hong Bu
Summary: Numb, a stem cell fate determinant, is closely related to malignancies and its loss promotes HPC expansion and iCCA development. Targeting suppressed Numb shows promise for iCCA treatment.
CELL DEATH & DISEASE
(2021)
Article
Gastroenterology & Hepatology
Celia Short, Allen Zhong, Jiabo Xu, Elaa Mahdi, Alison Glazier, Nicolas Malkoff, Nicolas Noriega, Theresa Yeo, Kinji Asahina, Kasper S. Wang
Summary: This study found that Prom1-expressing hepatic progenitor cells (HPCs) expand in biliary atresia (BA), giving rise to cholangiocytes within biliary ductular reactions. The TWEAK/FN14 signaling pathway mediates HPC proliferation, leading to fibrogenesis in BA.
Article
Plant Sciences
Yayuan Chen, Adriana Puentes, Christer Bjorkman, Agnes Brosset, Helena Bylund
Summary: Experiments conducted on Scots pine seedlings revealed significant differences in plant defense efficacy between MeJA and mechanical damage treatments. Needle-piercing damage treatment actually increased insect feeding, while MeJA significantly slowed down seedling growth.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yuanke Liang, Danielle Voshart, Judith T. M. L. Paridaen, Nynke Oosterhof, Dong Liang, Arun Thiruvalluvan, Inge S. Zuhorn, Wilfred F. A. den Dunnen, Guojun Zhang, Haoyu Lin, Lara Barazzuol, Frank A. E. Kruyt
Summary: This study reveals the important role of the cell adhesion molecule CD146 in regulating the aggressiveness of the brain tumor Glioblastoma (GBM). Elevated CD146 levels are correlated with higher tumor grades, poor response to treatment, and worse overall survival. CD146 overexpression enhances mesenchymal and invasive properties, stemness, and radiotherapy resistance in GBM. These findings suggest that CD146 could be a potential therapeutic target for GBM treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell & Tissue Engineering
Qian Wu, Xingxing Xu, Xuemeng Miao, Xiaomei Bao, Xiuchun Li, Ludan Xiang, Wei Wang, Siyu Du, Yi Lu, Xiwu Wang, Danlu Yang, Jingjing Zhang, Xiya Shen, Fayi Li, Sheng Lu, Yiren Fan, Shujie Xu, Zihao Chen, Ying Wang, Honglin Teng, Zhihui Huang
Summary: This study reveals the involvement of the S1P/S1PR2/YAP pathway in the regeneration of the olfactory epithelium after injury. Activation of YAP by S1P/S1PR2 signaling promotes the proliferation of horizontal basal cells (HBCs) and regeneration of the epithelium. Deletion of YAP impairs the regeneration of the olfactory epithelium and functional recovery of olfaction, while activation of YAP signaling enhances these processes.
Review
Plant Sciences
Guifang Zhang, Wu Liu, Zewei Gu, Shasha Wu, E. Yilan, Wenkun Zhou, Jinxing Lin, Lin Xu
Summary: This review summarizes the important role of jasmonate in plant regeneration. Jasmonate acts as a hormone linking wounding to different types of regeneration by regulating stem cell activities, cell proliferation, cell fate transition, and auxin production.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Biochemical Research Methods
Vinicius Lube, Mehmet Alican Noyan, Alexander Przybysz, Khaled Salama, Ikram Blilou
Summary: Profiling plant root architecture is crucial for selecting resilient crops, but the available imaging tools are costly and stationary. Nondestructive high-throughput phenotyping of roots also remains challenging.
Article
Plant Sciences
Aala A. Abulfaraj, Hanna M. Alhoraibi, Kiruthiga Mariappan, Jean Bigeard, Huoming Zhang, Marilia Almeida-Trapp, Olga Artyukh, Fatimah Abdulhakim, Sabiha Parween, Delphine Pflieger, Ikram Blilou, Heribert Hirt, Naganand Rayapuram
Summary: COILIN is a critical protein in Arabidopsis that regulates innate plant immunity through transcriptional, post-transcriptional, and steady-state protein level modulation. It acts as a key scaffolding component in the formation, composition, and activity of Cajal bodies (CBs). Furthermore, AtCOILIN is involved in alternative splicing (AS) and differential expression of genes related to RNA biogenesis, metabolism, plant immunity, and phytohormones. The findings highlight the important role of AtCOILIN in plant defense responses and innate plant immunity.
Article
Plant Sciences
Jian You Wang, Muhammad Jamil, Md. Golap Hossain, Guan-Ting Erica Chen, Lamis Berqdar, Tsuyoshi Ota, Ikram Blilou, Tadao Asami, Samir Jamil Al-Solimani, Magdi Ali Ahmed Mousa, Salim Al-Babili
Summary: The study found that the mimic of zaxinone (MiZax) can significantly enhance the growth and yield of crops such as tomato, capsicum, and squash, and requires less usage compared to widely used humic acid.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Nina Guarneri, Jaap-Jan Willig, Mark G. G. Sterken, Wenkun Zhou, M. Shamim Hasan, Letia Sharon, Florian M. W. Grundler, Viola Willemsen, Aska Goverse, Geert Smant, Jose L. L. Lozano-Torres
Summary: This study investigates the impact of cyst nematode infection on plant root architecture and its molecular mechanisms. It was found that cyst nematodes induce the formation of secondary roots, and the extent of increase is density-dependent. The study also reveals that jasmonate triggers secondary root formation through the ERF109 gene and local auxin biosynthesis. This research uncovers a novel mechanism underlying plant root plasticity in response to biotic stress.
Article
Plant Sciences
Jaap-Jan Willig, Nina Guarneri, Joris J. M. van Steenbrugge, Willem de Jong, Jingrong Chen, Aska Goverse, Jose L. Lozano Torres, Mark G. Sterken, Jaap Bakker, Geert Smant
Summary: This study reveals that the transcription factor TCP9 modulates the root system architectural plasticity to nematode infections via ROS-mediated processes, mitigating the impact of belowground biotic stresses.
Editorial Material
Biochemistry & Molecular Biology
Ikram Blilou, Heribert Hirt
Article
Plant Sciences
Yu Yang, Haneen Abuauf, Shanshan Song, Jian You Wang, Yagiz Alagoz, Juan C. Moreno, Jianing Mi, Abdugaffor Ablazov, Muhammad Jamil, Shawkat Ali, Xiongjie Zheng, Aparna Balakrishna, Ikram Blilou, Salim Al-Babili
Summary: The enzyme DWARF27 (D27) is responsible for the isomerization of β-carotene and the initiation of strigolactone (SL) biosynthesis. In this study, the enzymatic activity and biological function of D27-like1 were investigated. D27-like1 was found to contribute to SL biosynthesis by forming 9-cis-beta-carotene. Additionally, D27-like1 was found to affect the content of ABA and auxin.
Review
Plant Sciences
Heribert Hirt, Salim Al-Babili, Marilia Almeida-Trapp, Antoine Martin, Manuel Aranda, Dorothea Bartels, Malcolm Bennett, Ikram Blilou, Damian Boer, Alix Boulouis, Chris Bowler, Sophie Brunel-Muguet, Fabien Chardon, Jean Colcombet, Vincent Colot, Agata Daszkowska-Golec, Jose R. Dinneny, Ben Field, Katja Froehlich, Catherine H. Gardener, Alain Gojon, Eric Gomes, Eva Maria Gomez-Alvarez, Crisanto Gutierrez, Michel Havaux, Scott Hayes, Edith Heard, Michael Hodges, Amal Khalaf Alghamdi, Laurent Laplaze, Kyle J. Lauersen, Nathalie Leonhardt, Xenie Johnson, Jonathan Jones, Hannes Kollist, Stanislav Kopriva, Anne Krapp, Mauricio Lopez-Portillo Masson, Matthew F. McCabe, Livia Merendino, Antonio Molina, Jose L. Moreno Ramirez, Bernd Mueller-Roeber, Michael Nicolas, Ido Nir, Izamar Olivas Orduna, Jose M. Pardo, Jean-Philippe Reichheld, Pedro L. Rodriguez, Hatem Rouached, Maged M. Saad, Peter Schloegelhofer, Kirti A. Singh, Ive De Smet, Clara Stanschewski, Alice Stra, Mark Tester, Catherine Walsh, Andreas P. M. Weber, Detlef Weigel, Philip Wigge, Michael Wrzaczek, Brande B. H. Wulff, Iain M. Young
Summary: Greenhouse gas emissions are causing a global climate crisis, and immediate interventions are needed to mitigate their negative effects. Plant scientists are crucial in finding solutions for sustainable agriculture and land use, as it contributes significantly to total GHG emissions. The PlantACT! (Plants for climate ACTion!) initiative lays out a road map for plant scientists to contribute to finding immediate, mid-term, and long-term solutions, and highlights necessary changes at personal, institutional, and funding levels to implement these solutions.
TRENDS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Xiongjie Zheng, Yasha Zhang, Aparna Balakrishna, Kit Xi Liew, Hendrik N. J. Kuijer, Ting Ting Xiao, Ikram Blilou, Salim Al-Babili
Summary: Vitamin A deficiency is a global health issue that can be addressed by biofortifying crops with pro-vitamin A carotenoids. This study explores the engineering of carotenoid formation and storage in the cytosol of plant cells using a fungal carotenoid pathway. The engineered carotenoids accumulate in cytosolic lipid droplets and exhibit higher light stability compared to plastidial carotenoids. This research opens up opportunities for enhancing carotenoid biofortification in crops.
Article
Plant Sciences
Anna Siodmak, Umar Shahul F. Hameed, Naganand Rayapuram, Ronny Volz, Marie Boudsocq, Siba Alharbi, Hannah Alhoraibi, Yong-Hwan Lee, Ikram Blilou, Stefan T. Arold, Heribert Hirt
Summary: By studying the structure and function of Arabidopsis MPK4 protein, it was found that the CD domain is essential for the interaction and activation of MPK4 by upstream MAPKKs. Further experiments revealed the important role of a specific amino acid in the CD domain in protein activation. Additionally, the study also showed that the growth, development, and stress response functions of MPK4 require the activation of upstream MAPKK.
Article
Plant Sciences
Jesus Leon-Ruiz, Annie Espinal-Centeno, Ikram Blilou, Ben Scheres, Mario Arteaga-Vazquez, Alfredo Cruz-Ramirez
Summary: Our study reveals a novel mechanism of RBR function in transcriptional gene silencing by interacting with key players of the RdDM pathway in Arabidopsis and several plant clades.
Review
Plant Sciences
Gwendolyn K. Kirschner, Ting Ting Xiao, Muhammad Jamil, Salim Al-Babili, Vinicius Lube, Ikram Blilou
Summary: Parasitic plants invade their host through the formation of haustoria, which is facilitated by the plant hormones auxin and cytokinin.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Biochemistry & Molecular Biology
Anna Siodmak, Federico Martinez-Seidel, Naganand Rayapuram, Jeremie Bazin, Hanna Alhoraibi, Dione Gentry-Torfer, Naheed Tabassum, Arsheed H. Sheikh, Jose Kenyi Gonzalez Kise, Ikram Blilou, Martin Crespi, Joachim Kopka, Heribert Hirt
Summary: In plants, the MAMP-activated MAPK MPK6 regulates defense response through both transcriptional regulation and ribosomal protein translation machinery. The phosphorylation status of ribosomal proteins is specifically regulated by MAMP-activated MPK6, which affects protein translation by controlling the activity of P-stalk proteins.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Plant Sciences
Anamika Rawat, Ronny Volz, Arsheed Sheikh, Kiruthiga G. Mariappan, Soon-Kap Kim, Naganand Rayapuram, Khairiah M. Alwutayd, Louai K. Alidrissi, Moussa Benhamed, Ikram Blilou, Heribert Hirt
Summary: IDD4, a plant-specific transcription factor, plays an important role in salt stress tolerance. Genetic disruption of IDD4 increases salt tolerance, while overexpression of IDD4 enhances salt sensitivity. Phosphorylation of IDD4 is crucial for the transcriptional reprogramming of salt stress genes.
FRONTIERS IN PLANT SCIENCE
(2023)