Article
Biochemistry & Molecular Biology
Jonathan Carrasco-Sandoval, Mario Aranda, Karem Henriquez-Aedo, Marcos Fernandez, Amparo Lopez-Rubio, Maria Jose Fabra
Summary: This study aimed to investigate the impact of chitosan's molecular weight and degree of deacetylation on the bioaccessibility of quercetin encapsulated in alginate/chitosan-coated zein nanoparticles. The chitosan coating layer resulted in nanoparticulate systems with good stability, high encapsulation efficiency, and increased bioaccessibility of quercetin after in-vitro digestion. The best results were obtained using low molecular weight chitosan and high degree of deacetylation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Mousumi Sukul, Priyanka Sahariah, Helene L. Lauzon, Joao Borges, Mar Masson, Joao F. Mano, Havard J. Haugen, Janne E. Reseland
Summary: The DDA and Mw of chitosan sponges affect adhesion, growth, and differentiation of primary human osteoblasts. Higher DDA promotes the secretion of bone growth factors, while lower DDA promotes the secretion of other proteins. The variations in cellular responses to different chitosan sponges suggest potential for individual tailoring of desired responses in guided bone regeneration.
CARBOHYDRATE POLYMERS
(2021)
Article
Engineering, Biomedical
Jose Carlos Viana Ribeiro, Tereza Cristina Marques Forte, Samia Jessica Silva Tavares, Fabia Karine Andrade, Rodrigo Silveira Vieira, Vilma Lima
Summary: The study found that low molecular weight chitosan membranes can promote collagen deposition, reduce inflammation, and improve wound healing compared to high molecular weight chitosan membranes.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Biochemistry & Molecular Biology
Szymon Mania, Adrianna Banach-Kopec, Karol Staszczyk, Jolanta Kulesza, Ewa Augustin, Robert Tylingo
Summary: This study compares the antimicrobial activity and cytotoxicity of chitosan xerogels prepared by different dissolving and freeze-drying methods. The results show that the preparation method has an impact on the antimicrobial activity and cytotoxicity of the samples, and the presence of acid plays a crucial role in the antimicrobial activity of the polymer solution and its products.
CARBOHYDRATE RESEARCH
(2023)
Article
Food Science & Technology
Kader Tokatli, Aslihan Demirdoven
Summary: The study found that different chitosans had varying effects on the quality attributes of sweet cherries, with Chitosan-1 exhibiting the highest firmness value at 4 degrees Celsius and Chitosan-2 showing the highest total anthocyanin and total phenolic content under the same conditions. At 20 degrees Celsius, Commercial-1 had the highest antioxidant capacity and ascorbic acid content, while Chitosan-2 displayed the highest total anthocyanin content.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)
Review
Polymer Science
Cleidiane Goncalves, Nelson Ferreira, Lucia Lourenco
Summary: Chitosan's molecular weight can be regulated through different hydrolysis methods, with acid hydrolysis being the most commonly used method, but may cause environmental impacts. Combining different hydrolysis methods may be the most effective approach, although it could increase costs. Enzymatic hydrolysis is widely studied due to its environmental advantages and high specificity, but factors such as hydrolysis time and cost still limit its industrial application.
Article
Polymer Science
Nguyen Van Hoa, Nguyen Thi Hong Vuong, Nguyen Cong Minh, Hoang Ngoc Cuong, Trang Si Trung
Summary: The study demonstrates that CSNs prepared from squid pen chitosan with small size and excellent antibacterial activity have high potential applications in various fields.
Article
Chemistry, Multidisciplinary
Kiruthiga Periyannan, Hemamala Selvaraj, Balachandar Subbu, Muthukrishnan Pallikondaperumal, Ponmurugan Karuppiah, Jothi Ramalingam Rajabathar, Hamad Al-Lohedan, Sadhasivam Thangarasu
Summary: The exoskeleton waste of crabs, shrimp, and fish contains chitin, which can be extracted and utilized to produce chitosan, contributing to circular economy and waste management.
GREEN PROCESSING AND SYNTHESIS
(2023)
Article
Green & Sustainable Science & Technology
Danfeng Wang, Ruiying Song, Yue Liu, Jingyu Ren, Ying Zhang, Tiecheng Wang, Guangzhou Qu
Summary: This study developed a method to simultaneously produce low molecular weight chitosan and reducing sugars through chitosan depolymerization by surface discharge plasma. Active oxygen species and radicals in the discharge plasma played important roles in degrading chitosan and forming low molecular weight chitosan, which ultimately increased its biological activity. Discharge plasma could be an effective technique for chitosan depolymerization, expanding its potential applications.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Immunology
Hai-yu Ji, Chao Liu, Ke-yao Dai, Juan Yu, An-jun Liu, Ye-fu Chen
Summary: This study investigated the immunosuppressive effects of low molecular weight chitosan on mice with solid tumors, revealing its ability to disrupt immune organs, suppress immune cell activity, and decrease the expression of immune-related cytokines. The findings suggest that chitosan may not enhance immune response in cancer patients, but could be utilized in the treatment of autoimmune diseases or organ transplant recipients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Tadewos Lare, Belete Yilma Hirpaye, Ballekallu Chinna Eeranna, Babuskin Srinivasan
Summary: The fish and seafood processing industries generate significant waste, but this waste contains valuable substances such as chitin and chitosan. This study focuses on extracting and characterizing chitin and chitosan from fish waste, specifically Nile tilapia. The extracted chitosan is then used for apple juice clarification, effectively reducing total soluble solids, titratable acidity, and turbidity.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Review
Biochemistry & Molecular Biology
Shijie (Gabriel) Kou, Linda M. Peters, Michael R. Mucalo
Summary: This article discusses the production methods and different sources of chitosan, focusing on chemical and biological approaches, and suggests lobster cephalothorax as a potential source for industrial scale chitosan preparation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Hexiang Xie, Kefan Ouyang, Liqiong Zhang, Juwu Hu, Shengfang Huang, Weiwei Sun, Hua Xiong, Qiang Zhao
Summary: This study investigated the effect of different molecular weights of chitosan on the performance of composite films, revealing that lower molecular weight is beneficial for antioxidant and antibacterial activity of the films. Addition of rice hydrolysate improved the solubility and extensibility of the films, while the incorporation of curcumin further enhanced the bioactivities of the films.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Mi Wu, Shun Mao, Xu Liu, Yunen Liu, Peifang Cong, Jianhua Lv, Huaqin Tian, Yan Zhao
Summary: This study developed self-gelling and bioadhesive powders made of chitosan and polyacrylic acid, which effectively manage irregularly shaped, complex, and non-compressible wounds. These powders demonstrated excellent mechanical properties, significant antibacterial activities, strong and lasting adhesion on wet tissues, and accelerated blood clotting. They have great potential in managing acute hemorrhage of non-compressible trauma.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Energy & Fuels
Hulya Demirtas, Seyda Tasar, Fatih Kaya, Ahmet Ozer
Summary: This study aimed to synthesize chitosan-based gel microspheres and use them as a sorbent for BB41 dye molecules. The effects of chitosan deacetylation degree, molecular weight, cross-linking agent, cross-linking rate and time on sorption yield and capacity were investigated. The optimal conditions for microsphere production were determined, and the sorption yield and capacity were found to be approximately 99.5% and 10 mg/g, respectively.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Biochemistry & Molecular Biology
Gintautas Saulis, Raminta Rodaite-Riseviciene, Rita Saule
Summary: The experiment showed that the cell culture medium treated with high-voltage pulses was highly cytotoxic, leading to the death of all cells, while the medium treated with shorter pulses had lower cytotoxicity. The release of iron ions was sufficient to decrease cell viability, but was not the sole reason for cell death.
Article
Biochemistry & Molecular Biology
Nadia Tahari, Pedro L. de Hoyos-Martinez, Nagore Izaguirre, Nefzi Houwaida, Manef Abderrabba, Sameh Ayadi, Jalel Labidi
Summary: Chitosan/tannin/montmorillonite films are effective biosorbents for the removal of methyl orange from aqueous media. The films show high removal efficiency, large adsorption capacity, and follow pseudo second order kinetic and Langmuir isotherm models. Thermodynamic parameters suggest physical adsorption and exothermic behavior.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Environmental Sciences
Olfa Bachrouch, Houwaida Nefzi, Souhir Belloumi, Karima Horchani-Naifer, Jazia Sriti Eljazi, Soumaya Haoual Hamdi, Kamel Msaada, Jalel Labidi, Manef Abderrabba, Jouda Mediouni Ben Jemaa
Summary: This study investigated the composition and toxicity of Thyme essential oils (EOs) against two main stored grain insect pests. The results showed that the EOs had higher toxicity to the L. serricorne than the T. castaneum. The study also tested the combination of EOs with Tunisian Diatomaceous earths (DEs), which showed promising results in protecting stored grains.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Environmental Sciences
Amaia Morales, Jalel Labidi, Patricia Gullon
Summary: This study aimed to valorize walnut shells by sequential organosolv delignification and hydrothermal treatments, and successfully extracted lignin and cellulose nanocrystals, providing a new approach for the comprehensive utilization of walnut shells.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Polymer Science
Cristian Builes Cardenas, Vincent Gayraud, Maria Eugenia Rodriguez, Josep Costa, Asier M. Salaberria, Alaitz Ruiz de Luzuriaga, Nerea Markaide, Priya Dasan Keeryadath, Diego Calderon Zapateria
Summary: This research presents a comprehensive mechanical characterization of a new carbon fiber-reinforced vitrimer material. The vitrimer formulation combines thermoset properties with reprocessability, making it suitable for aeronautic-grade composite materials. The results demonstrate that the vitrimer formulation meets the requirements of current matrices for carbon-reinforced composites in the aerospace industry.
Article
Chemistry, Multidisciplinary
Yong-Ming Chen, Lian-Sheng Zang, Behlul Koc-Bilican, Ismail Bilican, Chris Holland, Demet Cansaran-Duman, Tugce Karaduman, Arzu Colak, Yasin Bayir, Zekai Halici, Sevilay Ozmen, Asad Ali, Jalel Labidi, Caglar Elbuken, Murat Kaya
Summary: MothMesh, a hierarchically structured nanofibrous surgical mesh derived from the cocoon of the Japanese giant silkworm, demonstrates non-toxicity, biocompatibility, suitable mechanical properties, and porosity, with potential for being an effective alternative to existing synthetic meshes.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Green & Sustainable Science & Technology
Amaia Morales, Jalel Labidi, Patricia Gullon
Summary: Lignin has shown promise as a natural polymer for the synthesis of hydrogels, and can be extracted from lignocellulosic materials such as nut shells. In this study, lignin was extracted from almond and walnut shells using different biorefinery schemes and then combined with poly (vinyl alcohol) to synthesize hydrogels. The results showed significant variations in the properties of the hydrogels depending on the different lignin samples used.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2022)
Article
Chemistry, Analytical
Rene Herrera, Eva Hermoso, Jalel Labidi, Juan I. Fernandez-Golfin
Summary: This study applied a novel methodology based on FTIR spectroscopy and chemometrics to classify the wood quality of Pinus nigra. It also attempted to classify the chemical differentiation of woody regions using specific IR bands. The results showed that the non-linear SVM-DA model performed better than the linear SIMCA and PLS-DA models in identifying wood quality.
MICROCHEMICAL JOURNAL
(2022)
Article
Environmental Sciences
Mahsa Mousavi Langari, M. Mirari Antxustegi, Jalel Labidi
Summary: The increase in industrial activities has raised serious concerns about water pollution caused by heavy metal ions. Nanocellulose, as a biocompatible material, has shown great potential in the development of sensors for the detection of these ions.
Review
Agricultural Engineering
Mateus Berwaldt Santos, Leyre Sillero, Darci Alberto Gatto, Jalel Labidi
Summary: Bioactive molecules are substances capable of interacting with living organisms and causing changes in them. Wood extractives contain significant amounts of these molecules, some of which exhibit good antioxidant and antimicrobial activity and can be used as preservatives. Conventional extraction methods have drawbacks such as high solvent, energy, and time consumption. To overcome these issues, new extraction techniques are being developed to optimize the process. Separation techniques like chromatography and molecular distillation can purify extractives and obtain desired molecules. This review provides an overview of the extraction and purification methods used for wood bioactive molecules, discussing factors such as raw material, solvent type, solid/liquid ratio, temperature, pressure, and extraction time. The application of extractives as preservatives for low durability woods is also analyzed. The study concludes that the quality and quantity of bioactive molecules depend on the methods and solvents employed for extraction, making the choice of method and solvent fundamental for achieving desired results.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Agricultural Engineering
Sarah Montes, Itxaso Azcune, Edurne Elorza, Alaitz Rekondo, Hans Grande, Jalel Labidi
Summary: Lignocellulosic biomass is a valuable source of energy and raw materials. Fractionation of the biomass into its main components, including cellulose, lignin, and hemicellulose, is necessary to fully utilize its potential. Ionic liquids have been explored as a sustainable alternative for biomass treatment due to their selectivity during fractionation. This study investigated the selective extraction of lignin from banana rachis using 6 different ionic liquids, including choline lactate which is known for its lack of toxicity and ease of synthesis from renewable resources.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Agricultural Engineering
Farida Baraka, Eduardo Robles, Jalel Labidi
Summary: Microwave-assisted synthetic pathway was used for the sustainable esterification of cellulose nanofibers (CNFs) using an aromatic amine compound. Nanofibers were isolated from unbleached and bleached eucalyptus pulp and their chemical composition, structural properties, morphology, and thermal properties were investigated.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Review
Polymer Science
Robson Andreazza, Amaia Morales, Simone Pieniz, Jalel Labidi
Summary: Hydrogels, particularly those based on gelatin, have shown great potential as polymers for various applications, such as biomedical purposes and environmental remediation. Gelatin, derived from collagen from the meat industry, adds value to waste materials like cartilage, bones, and skins. The biodegradability, non-toxicity, and easy cross-linking ability of gelatin-based hydrogels further enhance their performance and affordability.
Article
Chemistry, Multidisciplinary
Nagore Izaguirre, Javier Fernandez-Rodriguez, Eduardo Robles, Jalel Labidi
Summary: In this study, Kraft lignin was treated using mild oxidation conditions enhanced by ultrasound irradiation. The aim was to obtain functionalized particles while avoiding undesired side reactions. It was found that the oxidation reactions increased the carboxylic groups on the surface of the particles and promoted the formation of stable and nanosized particles.
Article
Chemistry, Multidisciplinary
Nagore Izaguirre, Javier Fernandez-Rodriguez, Eduardo Robles, Jalel Labidi
Summary: Kraft lignin was treated using mild oxidation conditions enhanced by ultrasound irradiation to obtain more functionalized particles without degradation and depolymerization. The best conditions for achieving stable and nanosized particles were found to be without the addition of hydrogen peroxide, at 30 degrees Celsius for 60 minutes. The reactions yielded good recovery rates, above 70% of the original lignin.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
