期刊
CANCER RESEARCH
卷 79, 期 7, 页码 1293-1294出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-19-0021
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- NCATS NIH HHS [UH3 TR000914] Funding Source: Medline
Both natural killer (NK) cells and exosomes released from these cells induce tumor cell cytotoxicity by way of the cell killing proteins perforin and granzyme. TGF beta 1 protein in the tumor microenvironment generates an immune escape mechanism rendering NK cells inactive. The tumor-suppressive miR-186 that is downregulated in neuroblastoma and in TGFb-treated NK cells represses oncogenic proteins in neuroblastoma (MYCN and AURKA) and components of the TGF beta pathway. Restoration of miR-186 levels in neuroblastoma through NK cell-derived exosomes or by nanoparticle delivery reduces tumor burden, promotes survival, and restores the cell-killing abilities of NK cells, demonstrating the therapeutic potential of tumor-suppressive miRNAs in neuroblastoma. See related article by Neviani and colleagues; Cancer Res 79(6): 1151-64
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