Review
Oncology
Ariadna Martin-Blazquez, Angeles Heredero, Gonzalo Aldamiz-Echevarria, Marta Martin-Lorenzo, Gloria Alvarez-Llamas
Summary: Thoracic aortic aneurysm (TAA) develops silently and asymptomatically, usually diagnosed incidentally, and lacks effective drugs and biological markers for early identification. Research aims to define novel markers for TAA and discuss the potential of previously identified molecules for early diagnosis/prognosis.
JOURNAL OF PATHOLOGY
(2021)
Article
Surgery
Anne-Sophie C. Romijn, Vinamr Rastogi, Jefferson A. Proano-Zamudio, Dias Argandykov, Christina L. Marcaccio, Georgios F. Giannakopoulos, Haytham M. A. Kaafarani, Vincent Jongkind, Frank W. Bloemers, Hence J. M. Verhagen, Marc L. Schermerhorn, Noelle N. Saillant
Summary: This study aims to compare the efficacy of early and delayed TEVAR for BTAI, and the results suggest that delayed TEVAR is associated with lower mortality risk.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yifan Guo, Xiaojun Chen, Xianda Lin, Litian Chen, Jiner Shu, Peipei Pang, Jianmin Cheng, Maosheng Xu, Zhichao Sun
Summary: A radiomic signature based on non-contrast CT images can effectively predict thoracic aortic dissections, serving as a potential screening tool for this condition. The predictive ability of the radiomic signature was demonstrated through high AUC values and good agreement with the probability of thoracic AD.
EUROPEAN RADIOLOGY
(2021)
Article
Genetics & Heredity
Renle Guo, Pengcheng Du, Yifei Pei, Jin Yang, Shuangshuang Li, Sheng Chang, Huiying Sun, Xiaomin He, Jian Dong, Jian Zhou, Zaiping Jing
Summary: This study identified mutations in COL3A1 and ACTA2 genes as the cause of familial TAAD, and identified other potential candidate genes. Future research may provide further insights into the pathogenic mechanism of TAAD.
FRONTIERS IN GENETICS
(2022)
Article
Cardiac & Cardiovascular Systems
Jason P. Glotzbach, Heidi A. Hanson, Joseph E. Tonna, Joshua J. Horns, Chelsea McCarty Allen, Angela P. Presson, Claire L. Griffin, Megan Zak, Vikas Sharma, Martin Tristani-Firouzi, Craig H. Selzman
Summary: In this large-population study, familial associations of thoracic aortic disease and bicuspid aortic valve (BAV) were examined. The risk of developing the same disease was found to be higher in relatives of patients with BAV, as well as in those with thoracic aortic aneurysm or dissection. Additionally, relatives of individuals with these diagnoses had a higher risk of aortic-specific mortality compared to controls.
Article
Cardiac & Cardiovascular Systems
Mohammad A. Zafar, Julia Fayanne Chen, Jinlin Wu, Yupeng Li, Dimitra Papanikolaou, Mohamed Abdelbaky, Thais Faggion Vinholo, John A. Rizzo, Bulat A. Ziganshin, Sandip K. Mukherjee, John A. Elefteriades
Summary: The study revealed that the mean growth rate of descending thoracic and thoracoabdominal aortic aneurysms was 0.19 cm/year, increasing with aortic size. Acute type B dissections frequently occurred at small aortic sizes, while fatal complications increased dramatically at 6.0 cm, suggesting the importance of preemptive intervention before this criterion to save lives.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Gabe Weininger, Makoto Mori, Michael Shang, Ellelan Degife, Michael Amick, Sameh Yousef, Roland Assi, Rita Milewski, Arnar Geirsson, Prashanth Vallabhajosyula
Summary: This study found that only a third of patients with incidentally detected ascending aortic aneurysms received any follow-up imaging within 1 year after detection, with very low clinical penetrance for expert referral. Surveillance of this high-risk patient population appears insufficient and may require standardization.
ANNALS OF THORACIC SURGERY
(2022)
Article
Biophysics
Shichao Zhu, Mieradilijiang Abudupataer, Shiqiang Yan, Chunsheng Wang, Li Wang, Kai Zhu
Summary: In this study, a new aorta smooth muscle-on-a-chip model was developed for TAA drug screening. Through this chip, researchers were able to rapidly and high-throughput screen multiple drugs simultaneously, and identified two drugs with the best therapeutic effects for TAA.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biology
Yonghui Qiao, Le Mao, Ying Ding, Ting Zhu, Kun Luo, Jianren Fan
Summary: TEVAR is the most effective treatment for aortic diseases, and this study evaluates the biomechanical implications of the implanted endograft after surgery. Using a novel computational framework, the study found that endograft implantation weakens the aorta's buffer function and reduces mean energy loss by 19.1%. The interaction between blood flow, endograft, and aortic wall is crucial for physiologically accurate hemodynamics post-TEVAR. The deformation of the aortic wall is responsible for the major energy loss in blood flow.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Randolph Hung-Leung Wong, Fan Yang, Takuya Fujikawa, Martin Chi-Sang Wong, Simon Chun-Ho Yu, Malcolm John Underwood, Alex Pui-Wai Lee
Summary: The study found that 7.5% of hypertensive patients in Hong Kong had asymptomatic thoracic aortic aneurysms, with male gender and older age being independent factors associated with TAA. The use of pocket-size mobile echocardiographic devices was effective in detecting TAA in a clinic setting, allowing for early detection and intervention to prevent catastrophic complications.
ANNALS OF THORACIC SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Sigrun Thorsteinsdottir, Gauti K. K. Gislason, Thor Aspelund, Saemundur Rognvaldsson, Jon Porir Oskarsson, Guorun A. Siguroardottir, Asdis R. Thordardottir, Brynjar Vidarsson, Pall T. Onundarson, Bjarni A. A. Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdottir, Isleifur Olafsson, Elias Eythorsson, Asbjoern Jonsson, Oscar Berlanga, Malin Hulcrantz, Brian G. M. Durie, Thorvardur J. Love, Stephen Harding, Ola Landgren, Sigurdur Y. Kristinsson
Summary: This study investigated the epidemiological characteristics of smoldering multiple myeloma (SMM) in the general population of Iceland. The prevalence of SMM in individuals 40 years or older was found to be 0.53%, with higher rates in men (0.67%) than in women (0.39%). The high prevalence of SMM has important implications for future treatment policies in multiple myeloma.
Article
Surgery
Anne-Sophie C. Romijn, Vinamr Rastogi, Christina L. Marcaccio, Ander Dorken-Gallastegi, Georgios F. Giannakopoulos, Vincent Jongkind, Frank W. Bloemers, Hence J. M. Verhagen, Marc L. Schermerhorn, Noelle N. Saillant
Summary: This study examined the association between sex and outcomes after thoracic endovascular aortic repair (TEVAR) for blunt thoracic aortic injury (BTAI) in younger patients. The results showed that female sex was not associated with higher in hospital mortality, but it was associated with a lower risk of acute kidney injury (AKI) and ventilator associated pneumonia (VAP).
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Heng Lu, Ling-chen Huang, Liang-wan Chen
Summary: The study evaluated the feasibility, efficacy, and safety of endovascular treatment of thoracic aortic pathologies involving the aortic arch. The results showed that endovascular surgery for lesions involving the arch was successful in reconstructing supra-aortic branches with low mortality and no neurological complications. This technique provides an effective and safe method for aortic arch reconstruction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Genetics & Heredity
Zhen Zhou, Alana C. Cecchi, Siddharth K. Prakash, Dianna M. Milewicz
Summary: This article discusses the main risk factors associated with thoracic aortic aneurysms and dissections (TAD), including genetic variants and environmental conditions, and explores the underlying mechanisms leading to TAD.
Article
Cardiac & Cardiovascular Systems
Lasse M. Obel, Axel C. Diederichsen, Flemming H. Steffensen, Lars Frost, Jess Lambrechtsen, Martin Busk, Grazina Urbonaviciene, Kenneth Egstrup, Marek Karon, Lars M. Rasmussen, Oke Gerke, Anders S. Bovling, Jes S. Lindholt
Summary: Aortic dilations may occur on any segment of the aorta, with varying pathogenesis and risk factors. This study found that the presence of coexisting aortic dilations is the most dominant predictor for dilations at any aortic segment.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)