Article
Environmental Sciences
Soyeon Jeon, Dong-Keun Lee, Jiyoung Jeong, Sung Ik Yang, Ji-Su Kim, Jinsik Kim, Wan-Seob Cho
Summary: This study investigated the toxicity of microplastics on different cell lines and found that microplastics showed significant toxicity to THP-1 macrophages, with toxicity correlated to the generation potential of reactive oxygen species (ROS). Weathering process reduced the ROS generation potential of microplastics, as weathered microplastics had increased affinity to bind serum protein acting as ROS scavenger.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Physical
Patryk Szymaszek, Patrycja Sroda, Malgorzata Tyszka-Czochara, Anna Chachaj-Brekiesz, Tomasz Swiergosz, Joanna Ortyl
Summary: Here we report the synthesis of a novel fluorescent probe P182 for quantitative measurement of H2O2. This fluorometric probe displays a fluorescence turn-on response in the presence of H2O2. It offers good performances in terms of sensitivity and response time, and shows non-toxic activity for in vivo studies. This study provides research on molecular fluorescence probe for the detection of H2O2.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Chemistry, Analytical
Wanchao Yu, Lixia Zhao
Summary: ROS, as important oxidizing species in ecosystems, play various roles and monitoring their concentration is crucial for the environment. The chemiluminescence method has attracted attention for ROS detection due to its high sensitivity and simplicity, showing advances in recent years.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Nerilson M. Lima, Gagan Preet, Sara R. Marqui, Thais de O. R. S. Falcoski, Geovana Navegante, Christiane P. Soares, Teresinha de Jesus A. S. Andrade, Felipe A. La Porta, Harinantenaina Liva R. Rakotondraie, Marcel Jaspars, Dulce H. S. Silva
Summary: This study evaluated the metabolic profiling and antigenotoxicity of Inga species with potential antitumor effects. It also used a proteomic approach to investigate the response of HepG2 cells to polyphenols isolated from I. laurina. The results showed cytotoxic activity against cancer cell lines and identified potential bioactive compounds. The proteomic analysis revealed proteins related to ROS elimination, DNA repair, tumor protein expression, and apoptosis.
Article
Biochemistry & Molecular Biology
Yuri Shatalin, Victoria S. Shubina, Marina E. Solovieva, Vladimir S. Akatov
Summary: The oxidation of thiols catalyzed by hydroxocobalamin (HOCbl) and cyanocobalamin (CNCbl) leads to reactive oxygen species (ROS) production and oxidative stress. The mechanisms and kinetics of thiol oxidation differ between HOCbl and CNCbl, affecting oxidation rate and ROS quenching. These findings provide new insight into the redox processes involving cobalamins and may contribute to the development of treatment approaches for oxidative stress-related cobalamin-responsive disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Loshini Soundararajan, Sudha Warrier, Arun Dharmarajan, Natarajan Bhaskaran
Summary: Reactive oxygen species (ROS) and its related signaling pathways and regulating molecules play a major role in the growth and development of cancer stem cells. CSCs possess robust self-renewal and tumorigenic potential, are resistant to conventional chemo- and radiotherapy, and eradicating CSCs may be the key to curing cancer. However, CSCs efficiently expel ROS by upregulating ROS scavengers, protecting them from ROS-mediated cell death and leading to chemoresistance and radioresistance.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Shanshan Gou, Lu Qiu, Qiufang Yang, Peng Li, Xiaowen Zhou, Yixuan Sun, Xiuman Zhou, Wenshan Zhao, Wenjie Zhai, Guodong Li, Yahong Wu, Yonggang Ren, Yuanming Qi, Yiguo Zhang, Yanfeng Gao
Summary: Metformin induces ROS accumulation by inhibiting the expression of the core antioxidant transcription factor NFE2L1, which can be reversed by high glucose. The inhibitory effect of metformin on NFE2L1 is AMPK-independent, and NFE2L1 may play a crucial role in regulating the AMPK signaling pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Agronomy
Saman Zahra, Sibgha Noreen, Rafia Abid, Ahmed Akram, Seema Mahmood, Tariq Shah, Abdulaziz Abdulla Alsahli
Summary: The growth potential of three minor fruit species after exposure to different nickel levels was evaluated. The results showed that nickel exposure negatively affected biomass elongation and caused oxidative damage. However, one of the species exhibited resilience through restricted nickel transfer, adequate nutrient uptake, and enhanced antioxidant enzyme biosynthesis.
Article
Biochemistry & Molecular Biology
Hyeryeon Oh, Dongwan Son, Jin Sil Lee, Myungwoong Kim, Daekyung Sung, Hoik Lee, Won Il Choi
Summary: This study developed PBChi/PVA nanofibers with antioxidant and cell proliferation properties as ROS-scavenging wound dressings. These nanofibers effectively removed reactive oxygen species and exhibited good biocompatibility and cell proliferation ability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Lirong Yu, Xuemei Zhang, Feng Zhang, Yingbo Tang, Di Gong, William Oyom, Yongcai Li, Dov Prusky, Gianfranco Romanazzi, Yang Bi
Summary: Both chitosan (CTS) and chitooligosaccharide (COS) can regulate reactive oxygen species (ROS) homeostasis during wound healing of pear fruit by scavenging excessive H2O2 and improving antioxidant capacity. They increase NADPH oxidase and superoxide dismutase activities, promote O2.- and H2O2 production, enhance the activities of several enzymes, and elevate the levels of ascorbic acid and glutathione. In addition, they improve antioxidant capacity in vitro and maintain cell membrane integrity at fruit wounds. COS demonstrates superior performance over CTS.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Environmental
Steven Lelieveld, Jake Wilson, Eleni Dovrou, Ashmi Mishra, Pascale S. J. Lakey, Manabu Shiraiwa, Ulrich Poeschl, Thomas Berkemeier
Summary: Air pollutants such as aerosols and ozone can cause the generation of reactive oxygen species in the human respiratory tract, leading to oxidative stress and adverse health effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Plant Sciences
Sabina Ackah, Yang Bi, Sulin Xue, Salimata Yakubu, Ye Han, Yuanyuan Zong, Richard Atinpoore Atuna, Dov Prusky
Summary: This study investigated the effects of post-harvest chitosan treatment on ROS production, cell membrane integrity, and antioxidant systems in wounded apples during storage. The results showed that chitosan treatment stimulated antioxidant enzyme activities and reduced lipid peroxidation and membrane permeability in the wounded fruits. Additionally, chitosan increased the activities and substrates of the ascorbate-glutathione cycle-related enzymes. These findings suggest that chitosan can scavenge ROS and maintain fruit membrane integrity, making it a favorable preservative for inducing stress tolerance and preserving fruit quality.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mohd Jahir Khan, Abrar Ahmad, Mahmood Ahmad Khan, Sahabjada Siddiqui
Summary: This study investigated the anticancer properties of zinc oxide nanoparticles (ZnO-NPs) on human epidermoid carcinoma cells and found that ZnO-NPs induce apoptosis in A431 cells through DNA degradation and generation of reactive oxygen species via p53, bax/bcl-2, and caspase pathways.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Chemistry, Analytical
Rohini Kumari, Daphika S. Dkhar, Supratim Mahapatra, Divya, Rahul Kumar, Pranjal Chandra
Summary: Reactive oxygen species play an important role in cell signaling but excessive production is associated with various diseases. Traditional detection methods have limitations, while biosensing technology has emerged as a major approach. This review discusses recent biosensors for monitoring reactive oxygen species and highlights the progress of nanotechnology and biomimetic engineering in biosensing.
MICROCHEMICAL JOURNAL
(2022)
Article
Environmental Sciences
Songjie He, Xin Lian, Bo Zhang, Xianjun Liu, Jia Yu, Yifan Gao, Qingmei Zhang, Hongyan Sun
Summary: The application of nano silicon dioxide (nSiO(2)) can alleviate Cd toxicity in barley by promoting plant growth, improving photosynthesis, reducing Cd concentration and MDA content, and enhancing antioxidant enzyme activities. Therefore, exogenous nSiO(2) application may be an effective method to address Cd toxicity in barley plants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Organic
Igor K. Yakuschenko, Nataliya N. Pozdeeva, Viktoriya A. Mumyatova, Alexey A. Terentiev, Svyatoslav Ya Gadomsky
Summary: Iso-octenidine, a new isomer of octenidine dihydrochloride, was found to be 3 times more soluble in water compared to the original compound. Despite this difference in solubility, both substances exhibited similar antibacterial activity against Escherichia Coli and Micrococcus luteus.
CURRENT ORGANIC SYNTHESIS
(2021)
Article
Chemistry, Inorganic & Nuclear
N. A. Sanina, G. Kozub, T. A. Kondrat'eva, T. S. Stupina, A. A. Balakina, A. A. Terent'ev, I. Sulimenkov, N. S. Ovanesyan, P. Dorovatovskii, V. N. Khrustalev, S. M. Aldoshin
Summary: The study described the chemical properties and biological activities of a binuclear tetranitrosyliron complex in solution, including the formation of long-living nitrosyl intermediates and its effects on NF-kappa B p50 and p65 levels in the nucleus, leading to inhibition of NF-kappa B dependent genes, as well as induction of p53 protein levels and p21 gene activity, resulting in apoptotic cell death.
JOURNAL OF COORDINATION CHEMISTRY
(2021)
Article
Chemistry, Physical
Eugene Pliss, Mikhail Soloviev, Vasiliy Sen', Roman Pliss, Andrey Sirik, Ivan Tikhonov
Summary: The mechanism of oxidation of 1,2-substituted ethylene and 1,4-substituted butadiene with cyclic multiple chain termination by nitroxide radicals has been confirmed through a variety of nitroxides. The solvent effect on the rate constant of nitroxide and hydroperoxide radicals interaction is explained by specific solvation of radicals. The reactivity of > NO center dot in low polar solvents is determined by > NO-H bond energy of hydroxylamine.
REACTION KINETICS MECHANISMS AND CATALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Marina V. Lebedeva, Ekaterina Y. Nikonova, Alexey A. Terentiev, Vasiliy V. Taranov, Alexey V. Babakov, Oleg S. Nikonov
Summary: The study revealed that the VPg variant from PVY strain NTN interacts with eIF4E1 and eIF4E2 in potatoes, but not with eIF(iso)4E. Mutants of VPg were created and tested for their interaction with potato eIF4E factors to build a new theoretical model of the VPg-eIF4E2 complex.
BIOCHEMISTRY-MOSCOW
(2021)
Article
Chemistry, Medicinal
Galina F. Makhaeva, Sofya Lushchekina, Natalia P. Boltneva, Olga G. Serebryakova, Nadezhda Kovaleva, Elena Rudakova, Natalia A. Elkina, Evgeny Shchegolkov, Yanina Burgart, Tatyana S. Stupina, Alexey A. Terentiev, Eugene Radchenko, Vladimir A. Palyulin, Victor Saloutin, Sergey O. Bachurin, Rudy J. Richardson
Summary: A series of expanded HOPs inhibitors were synthesized via Cu(OAc)(2)-catalyzed azo coupling, showing nanomolar inhibition towards carboxylesterase and potent antioxidant properties. Among them, a pentafluoroethyl-substituted HOP exhibited high selectivity towards a specific type of human CES enzyme.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Tatiana S. Kokovina, Svyatoslav Y. Gadomsky, Alexei A. Terentiev, Nataliya A. Sanina
Summary: The study aimed to develop a new method for synthesizing 1,3,4-thiadiazol-2-amine derivatives using a one-pot reaction between thiosemicarbazide and carboxylic acid in the presence of polyphosphate ester (PPE). This method avoids the use of toxic additives such as POCl3 or SOCl2 and successfully synthesized five target compounds. The structures of all compounds were confirmed using mass spectrometry, IR, and NMR spectroscopies.
Article
Biochemistry & Molecular Biology
Anastasia Balakina, Tatyana Prikhodchenko, Vera Amozova, Tatyana Stupina, Victoria Mumyatova, Margarita Neganova, Ilya Yakushev, Alexey Kornev, Svyatoslav Gadomsky, Boris Fedorov, Denis Mishchenko
Summary: The hybrid compound B6NO effectively chelates iron ions to block the Fenton reaction, inhibits lipid peroxidation more effectively, decreases ROS concentration in normal cells showing antioxidant properties, but exhibits lower antioxidant activity on tumor cells and lower cytotoxicity for normal cells.
Article
Biochemistry & Molecular Biology
Vasily D. Sen, Anastasiya A. Balakina, Tatyana S. Stupina, Victoriya A. Mumyatova, Alexander V. Kulikov, Ivan V. Tikhonov, Alexei A. Terent'ev, Evgeny M. Pliss
Summary: The study successfully synthesized new CPAs micelles by binding aminoxyls to amphiphilic chitosans, finding that the rigidity of the aminoxyl-polymer bond and sulfation affect the EPR spectra. CPAs demonstrated good antioxidant activity and low cytotoxicity, showing potential for carrying anti-tumor drugs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Igor V. Rzhepakovsky, David A. Areshidze, Svetlana S. Avanesyan, Wolf D. Grimm, Natalya V. Filatova, Aleksander V. Kalinin, Stanislav G. Kochergin, Maria A. Kozlova, Vladimir P. Kurchenko, Marina N. Sizonenko, Alexei A. Terentiev, Lyudmila D. Timchenko, Maria M. Trigub, Andrey A. Nagdalian, Sergei I. Piskov
Summary: The methanolic extract of leaves of Chlorophytum comosum contains various bioactive constituents, including a compound not previously found in Chlorophytum. The water fraction of the extract exhibits promising antitumor potential.
Article
Spectroscopy
A. Yu Belik, A. Yu Rybkin, N. S. Goryachev, A. P. Sadkov, N. Filatova, A. G. Buyanovskaya, V. N. Talanova, Z. S. Klemenkova, V. S. Romanova, M. O. Koifman, A. A. Terentiev, A. Kotelnikov
Summary: The study focused on the synthesis and photodynamic activity of water-soluble amino acid fullerene C-60 derivatives (AFD) and their covalent addition of dye pyropheophorbide (PPa) in aqueous solution. The dyads formed nanoassociates through self-assembly, exhibiting a switch in photodynamic mechanism from type II to I and significant phototoxicity in Hela cells, suggesting potential against hypoxic tumors.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Inorganic & Nuclear
Evgenii M. Pliss, Mikhail E. Soloviev
Summary: This study presents a quantum-chemical analysis of the effect of a constant magnetic field on radical formation during the chain oxidation of organic compounds by molecular oxygen. The results show that the magnetic field has an influence on the evolution of radical pairs in the different stages of chain oxidation.
Article
Chemistry, Inorganic & Nuclear
Nataliya A. Sanina, Igor K. Yakuschenko, Svyatoslav Ya Gadomskii, Andrei N. Utenyshev, Pavel Dorovatovskii, Vladimir A. Lazarenko, Nina S. Emel'yanova, Evgeniya A. Zagainova, Nikolai S. Ovanesyan, Victoriya A. Mumyatova, Anastasiya A. Balakina, Alexey A. Terent'ev, Sergey M. Aldoshin
Summary: This study focuses on synthesizing and investigating a new series of antibacterial agents, which are dimers of dinitrosyl iron complexes. The study explores the molecular structure and stabilization mechanisms of these complexes, and evaluates their antibacterial activity.
Article
Chemistry, Inorganic & Nuclear
Vyacheslav N. Kazin, Evgenii A. Guzov, Valentina A. Moshareva, Evgenii M. Pliss
Summary: This research investigates the influence of a magnetic field on the oxidative transformations of adrenaline through experimental data and kinetic analysis. In the case of autoxidation, the rate of adrenaline consumption is controlled by the superoxide radical concentration, which increases with the applied magnetic field strength and leads to a decrease in the initiation rate of the quinoid process. In the case of initiated oxidation, the observed magnetic effect is explained by the influence on the chain termination mechanism and/or initiation mechanism of the autoxidation process.
Article
Biochemistry & Molecular Biology
Anastasia Balakina, Svyatoslav Gadomsky, Tatyana Kokovina, Tatyana Sashenkova, Denis Mishchenko, Alexei Terentiev
Summary: Using a novel method, new N-hydroxybutanamide derivatives were synthesized and evaluated for their ability to inhibit matrix metalloproteinases (MMPs) and their cytotoxicity. One derivative showed significant inhibition of MMPs and low toxicity towards cancer cells. In a mouse model, it demonstrated antitumor and antimetastatic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
