Article
Multidisciplinary Sciences
Andrea Slezia, Panna Hegedus, Evgeniia Rusina, Katalin Lengyel, Nicola Solari, Attila Kaszas, Diana Balazsfi, Boris Botzanowski, Emma Acerbo, Florian Missey, Adam Williamson, Balazs Hangya
Summary: Studying animal models allows us to better understand the mechanisms of Parkinson's disease. However, current models mainly focus on late-stage symptoms, leaving a gap in our knowledge of early-stage changes. In this study, a graded-dose unilateral 6-OHDA model was established in mice, and the behavioral, neuronal, and ultrastructural features were analyzed within the first two weeks of lesion induction. The results showed that mild degeneration of dopaminergic neurons can lead to motor deficits shortly after striatal lesions, suggesting that this model can be used to study the early stages of Parkinson's disease in mice.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Esther Gramage, Jorge Saiz, Rosalia Fernandez-Calle, Yasmina B. Martin, Maria Uribarri, Marcel Ferrer-Alcon, Coral Barbas, Gonzalo Herradon
Summary: This study found that overexpression of PTN has a neuroprotective effect in a mouse model of Parkinson's Disease and identified potential lipid-related drug candidates for Parkinson's Disease.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Dongning Su, Yawen Gan, Zhe Zhang, Yusha Cui, Zhijin Zhang, Zhu Liu, Zhan Wang, Junhong Zhou, Vesna Sossi, A. Jon Stoessl, Tao Wu, Jing Jing, Tao Feng
Summary: Using multimodal magnetic resonance imaging, this study identified significant structural and functional changes in the substantia nigra of patients with Parkinson's disease and levodopa-induced dyskinesia. These findings provide new insights into the pathophysiological mechanisms underlying Parkinson's disease with dyskinesia.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Tianbin Song, Jiping Li, Shanshan Mei, Xiaofei Jia, Hongwei Yang, Yongquan Ye, Jianmin Yuan, Yuqing Zhang, Jie Lu
Summary: This study found higher iron deposition in the substantia nigra of PD patients with LID compared to those without LID. The QSM value of the SN may be a potential early diagnostic neuroimaging biomarker for LID.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Marcello Serra, Annalisa Pinna, Giulia Costa, Alessandro Usiello, Massimo Pasqualetti, Luigi Avallone, Micaela Morelli, Francesco Napolitano
Summary: Rhes is a gene regulated by thyroid hormones that modulates dopamine neurotransmission through inhibition of the striatal cAMP/PKA pathway. It is expressed at high levels in the dorsal striatum and is involved in the survival of midbrain dopaminergic neurons, pointing towards a modulation of autophagy and mitophagy processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Indriani Dwi Wahyu, Satomi Chiken, Taku Hasegawa, Hiromi Sano, Atsushi Nambu
Summary: Studies using a PD mouse model showed that GPe and SNr neurons exhibited different spontaneous activity and cortically evoked responses in the PD and dyskinesia states, suggesting that the occurrence of LID is associated with the neural activity patterns of these two nuclei.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Tung-Tai Kuo, Yuan-Hao Chen, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H. H. Greig, Jin Jung, Ho- Choi, Lars Olson, Barry J. J. Hoffer, Kuan-Yin Tseng
Summary: This study evaluated the efficacy of PT320 on L-DOPA-induced dyskinetic behaviors and neurochemistry in a progressive Parkinson's disease MitoPark mouse model. The results showed that early administration of PT320 significantly reduced the severity of L-DOPA-induced abnormal involuntary movements, particularly in excessive standing and abnormal paw movements. However, late administration of PT320 did not improve any L-DOPA-induced dyskinesia measurements. Furthermore, early treatment with PT320 increased both tonic and phasic release of dopamine in striatal slices, indicating its potential role in alleviating L-DOPA-induced dyskinesia in Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Rayanne Poletti Guimaraes, Danilo Leandro Ribeiro, Keila Bariotto dos Santos, Livea Dornela Godoy, Mirella Rosine Correa, Fernando Eduardo Padovan-Neto
Summary: The motor symptoms of Parkinson's disease are primarily caused by neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta and dopaminergic striatal deficit. Animal models are widely used to simulate PD pathology in the laboratory, with rodents being the most commonly used due to their ease of handling and maintenance.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Biochemistry & Molecular Biology
Sangeun Han, Min Hyung Seo, Sabina Lim, Sujung Yeo
Summary: This study suggests a potential association between reduced ITGA7 expression and increased alpha-syn expression and apoptosis of dopaminergic cells in an MPTP-induced PD mouse model. This is the first study to show a link between ITGA7 and PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Lei Wang, Shengyu Li, Yu Jiang, Zijian Zhao, Yunjiao Shen, Junjie Zhang, Lei Zhao
Summary: Probiotic Lactobacillus plantarum DP189 has a significant protective effect on the dopaminergic neurons in the substantia nigra of Parkinson's disease mice, improving behavioral abilities and increasing neurotransmitter levels.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Clinical Neurology
Tushar Kamath, Evan Z. Macosko
Summary: Parkinson's disease is characterized by the death of dopaminergic neurons in the substantia nigra. Recent advances in genomic profiling have identified specific pathways and genetic variants involved in the susceptibility of dopaminergic neurons in Parkinson's disease. This provides new opportunities for understanding and developing therapies for this complex disorder.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Marta Gonzalez-Sepulveda, Joan Compte, Thais Cuadros, Alba Nicolau, Camille Guillard-Sirieix, Nuria Penuelas, Marina Lorente-Picon, Annabelle Parent, Jordi Romero-Gimenez, Joana M. Cladera-Sastre, Ariadna Laguna, Miquel Vila
Summary: Neurons that accumulate the highest levels of neuromelanin with age are also the most susceptible to degeneration in Parkinson's disease. Using a neuromelanin-producing rat model, Gonzalez-Sepulveda, Compte et al. show that slowing down age-dependent neuromelanin production can help prevent Parkinson's disease-like features.
Article
Biochemistry & Molecular Biology
Bok-Seok Kim, Taeik Jang, Sung-Eun Yoo, Jae Moon Lee, Eunhee Kim
Summary: The impairment of protein clearance mechanisms in dopaminergic neurons leads to the accumulation of alpha-synuclein, contributing to the pathogenesis of Parkinson's disease. Fas-associated factor 1 (FAF1) was found to disrupt alpha-synuclein clearance through the autophagy-lysosome pathway, indicating a novel role as a negative regulator of autophagic alpha-synuclein clearance. This disturbance ultimately leads to alpha-synuclein accumulation and autophagy dysregulation in PD model mice.
Article
Biochemistry & Molecular Biology
Xingxing Jian, Guihu Zhao, He Chen, Yanhui Wang, Jinchen Li, Lu Xie, Bin Li
Summary: This study utilized transcriptomics analysis to identify several hub DEGs between PD patients and normal controls, showing high correlations among these genes. A Cox model with an eight-gene signature was constructed to predict PD progression and survival successfully in an independent dataset, highlighting the clinical significance of these findings.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Cell Biology
Isaac Deng, Larisa Bobrovskaya
Summary: Parkinson's disease, a common movement disorder, is strongly associated with neuroinflammation. The administration of lipopolysaccharide can be used to study the neuroinflammatory aspects of Parkinson's disease. Lipopolysaccharide mouse models are useful tools for future research in this field.
NEURAL REGENERATION RESEARCH
(2022)
Article
Neurosciences
Isabel Espadas, Oscar Ortiz, Patricia Garcia-Sanz, Adrian Sanz-Magro, Samuel Alberquilla, Oscar Solis, Jose Maria Delgado-Garcia, Agnes Gruart, Rosario Moratalla
Summary: The genetic inactivation of D2R impairs spatial memory, associative learning, and classical conditioning of eyelid responses, as well as reduces activity-dependent synaptic plasticity in the hippocampal CA1-CA3 synapse. These findings demonstrate the key role of D2R in regulating hippocampal plasticity changes and affecting the acquisition and consolidation of spatial and associative forms of memory.
Article
Neurosciences
Juan P. Beccaria, Carlos A. Pretell Annan, Ettel Keifman, M. Gustavo Murer, Juan E. Belforte
Summary: This study provides evidence that striatal cholinergic interneurons (SCINs) modulate their activity in the selection of behavioral strategies. The results show that depletion of SCINs in adult mice impairs their ability to shift away from initially adopted strategies. This suggests that SCINs play a critical role in resolving cognitive conflicts and may contribute to the emergence of perseverative/compulsive traits in neuropsychiatric disorders.
JOURNAL OF NEUROSCIENCE
(2022)
Letter
Biochemistry & Molecular Biology
Jordi Bonaventura, Sherry Lam, Meghan Carlton, Matthew Boehm, Juan L. Gomez, Oscar Solis, Marta Sanchez-Soto, Patrick J. Morris, Ida Fredriksson, Craig J. Thomas, David R. Sibley, Yavin Shaham, Carlos A. Zarate, Michael Michaelides
MOLECULAR PSYCHIATRY
(2022)
Article
Clinical Neurology
Rodrigo Manuel Paz, Agostina Monica Stahl, Lorena Rela, Mario Gustavo Murer, Cecilia Tubert
Summary: This study unravels the mechanisms underlying the abnormal activity of striatal cholinergic interneurons (SCIN) in Parkinson's disease (PD) patients treated with levodopa, and suggests that pharmacological interventions can restore their normal function.
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Tomas E. Sachella, Marina R. Ihidoype, Christophe D. Proulx, Diego E. Pafundo, Jorge H. Medina, Pablo Mendez, Joaquin Piriz
Summary: Fear is a pathological condition that can be studied using fear conditioning, which is the best-understood model of fear learning. This study investigates the role of the lateral habenula in fear conditioning and finds that it is involved in the formation of independent contextual and cued fear memories.
NEUROPSYCHOPHARMACOLOGY
(2022)
Letter
Biochemistry & Molecular Biology
Jordi Bonaventura, Sherry Lam, Meghan Carlton, Matthew Boehm, Juan L. Gomez, Oscar Solis, Marta Sanchez-Soto, Patrick J. Morris, Ida Fredriksson, Craig J. Thomas, David R. Sibley, Yavin Shaham, Carlos A. Zarate, Michael Michaelides
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Ettel Keifman, Camila Coll, Cecilia Tubert, Rodrigo M. Paz, Juan E. Belforte, Mario G. Murer, Barbara Y. Braz
Summary: In Parkinson's disease patients and rodent models, loss of dopaminergic neurons results in severe motor disabilities. However, in rodents, general motility is preserved after early postnatal loss of dopaminergic neurons. This preservation is likely due to functional changes in certain neurons in the brain.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Emilya Ventriglia, Arianna Rizzo, Juan L. Gomez, Jacob Friedman, Sherry Lam, Oscar Solis, Rana Rais, Jordi Bonaventura, Michael Michaelides
Summary: Oliceridine is a selective μ-opioid receptor agonist that exerts its analgesic effects through its interaction with P-glycoprotein (P-gp), rather than its weak intrinsic efficacy or biased agonism.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Pediatrics
Eduardo Vainstein, Silvia Baleani, Luis Urrutia, Nicolas Affranchino, Judith Ackerman, Mariana Cazalas, Alejandro Goldsman, Angela Sardella, Ana Laura Tolin, Pablo Goldaracena, Mariana Fabi, Mariana Cosentino, Ricardo Magliola, Gustavo Roggiero, Paula Manso, Jesica Triguy, Celeste Ballester, Vanesa Cervetto, Maria Vaccarello, Domingo Norberto De Carli, Maria Estela De Carli, Ana Laura Ciotti, Maria Irene Sicurello, Cecilia Rios Leiva, Claudia Villalba, Maria Hortas, Sonia Pena, Gabriela Gonzalez, Camila Lidia Zold, Mario Gustavo Murer
Summary: This observational study aimed to understand the characteristics and outcomes of pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in Argentina. The results showed that the rates of severe outcomes of PIMS-TS were consistent with those observed in high-income countries. Together with other published studies, this work helps clinicians to better understand this novel clinical entity.
PEDIATRICS INTERNATIONAL
(2023)
Article
Biology
Maria Cecilia Martinez, Camila Lidia Zold, Marcos Antonio Coletti, Mario Gustavo Murer, Mariano Andres Belluscio
Summary: The activity of the striatum plays a role in the timing of action sequence initiation and is linked to impulsivity. This modulation is more pronounced in adolescent rats, potentially reflecting age-related differences in reward expectation and temporal discounting.
Article
Multidisciplinary Sciences
Oscar Solis, Andrea R. Beccari, Daniela Iaconis, Carmine Talarico, Camilo A. Ruiz-Bedoya, Jerome C. Nwachukwu, Annamaria Cimini, Vanessa Castelli, Riccardo Bertini, Monica Montopoli, Veronica Cocetta, Stefano Borocci, Ingrid G. Prandi, Kelly Flavahan, Melissa Bahr, Anna Napiorkowski, Giovanni Chillemi, Masato Ooka, Xiaoping Yang, Shiliang Zhang, Menghang Xia, Wei Zheng, Jordi Bonaventura, Martin G. Pomper, Jody E. Hooper, Marisela Morales, Avi Z. Rosenberg, Kendall W. Nettles, Sanjay K. Jain, Marcello Allegretti, Michael Michaelides
Summary: This study discovered an interaction between the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human estrogen receptor alpha (ER alpha), and identified a highly conserved and functional nuclear receptor coregulator (NRC) LXD-like motif on the S2 sub-unit.
Article
Multidisciplinary Sciences
Stylianos Kouvaros, Brandon Bizup, Oscar Solis, Manoj Kumar, Emilya Ventriglia, Fallon P. Curry, Michael Michaelides, Thanos Tzounopoulos
Summary: Synaptic zinc is an important neuromodulator that affects synaptic transmission and sensory processing. By using a novel dual recombinase transgenic mouse, researchers have been able to study the mechanisms and functions of synaptic zinc in a more controlled and specific manner. The findings from this study reveal a new neuromodulatory mechanism involving zinc release and NMDA receptor activity in the cortex.
Article
Neurosciences
Maria Saez, Ettel Keifman, Samuel Alberquilla, Camila Coll, Ramon Reig, Mario Gustavo Murer, Rosario Moratalla
Summary: This study found that D2-type dopamine receptors and the striatopallidal pathway play important roles in modulating dyskinesia, and suggest that targeting striatopallidal axon terminals at the GPe may have therapeutic potential in the management of LID.
NEUROBIOLOGY OF DISEASE
(2023)