Review
Pharmacology & Pharmacy
Christian Holscher
Summary: Type 2 diabetes and insulin desensitization have been linked to neurodegenerative disorders like Alzheimer's and Parkinson's diseases. GLP-1 and GIP hormones have shown neuroprotective effects in trials, suggesting potential disease-modifying care for patients.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Clinical Neurology
Xiaoyan Yang, Qiang Qiang, Nan Li, Peng Feng, Wenshi Wei, Christian Hoelscher
Summary: The global burden of ischemic stroke, a major public and social health concern, is on the rise. Hyperglycemia increases the risk of stroke, particularly in patients with diabetes. Treatment for ischemic stroke focuses on restoring cerebral blood flow and improving neurological impairment. GLP-1 RAs are considered to have neuroprotective effects in ischemic stroke.
FRONTIERS IN NEUROLOGY
(2022)
Review
Pharmacology & Pharmacy
Federica Ferrari, Antonio Moretti, Roberto Federico Villa
Summary: Alzheimer's disease (AD) and Parkinson's disease (PD) are the most frequent neurodegenerative disorders. The current treatments are only symptomatic and there is evidence that type 2 diabetes mellitus is a major risk factor for AD and PD. Insulin resistance in the brain plays a crucial role in their neuropathological processes. Therefore, insulin-based treatments have been suggested. However, alternative strategies based on GLP-1 and GIP have been researched due to the adverse effects of insulin.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Neurosciences
Amanda Amorim Mugayar, Giovanna da Silva Guimaraes, Paulo Henrique Tavares de Oliveira, Renan Lyra Miranda, Aline Araujo dos Santos
Summary: The α7 subtype of nicotinic receptors is highly expressed in the central nervous system and plays an important role in promoting neuroprotection by modulating apoptotic pathways. Activation of α7 nAChRs leads to the stimulation of anti-apoptotic molecules and the reduction of proapoptotic molecules, resulting in cell survival. Studies have shown that the activation of α7 nAChRs can attenuate neurotoxicity and provide neuroprotection in models of neurodegenerative diseases such as Alzheimer's disease.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Shang-Der Chen, Yao-Chung Chuang, Tsu-Kung Lin, Jenq-Lin Yang
Summary: Aging is a crucial risk factor for neurodegenerative diseases, and GLP-1R agonists may have beneficial effects in treating these diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Carmen M. Labandeira, Arturo Fraga-Bau, David Arias Ron, Ana Munoz, Gema Alonso-Losada, Antonio Koukoulis, Jesus Romero-Lopez, Ana Rodriguez-Perez
Summary: Parkinson's disease and diabetes mellitus are two chronic disorders associated with aging that are increasingly prevalent worldwide. Research has shown that insulin plays a role in the brain that may affect the development of Parkinson's disease, and some antidiabetic treatments may have a certain impact on this disease.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alejandro Quintero-Villegas, Sergio Ivan Valdes-Ferrer
Summary: 5-HT7 receptors are the most recently identified among serotonin receptors, and their role in neurodegenerative diseases is not fully understood. This review discusses the signaling pathways and cellular mechanisms involved in 5-HT7R activation, as well as the potential therapeutic implications of pharmacological interventions for 5-HT7R signaling in neurodegeneration.
MOLECULAR MEDICINE
(2022)
Article
Chemistry, Medicinal
Urte Sachleviciute, Gabriel Gonzalez, Marie Kvasnicova, Sarka Stepankova, Neringa Kleiziene, Aurimas Bieliauskas, Marek Zatloukal, Miroslav Strnad, Frank A. Slok, Miroslav Kvasnica, Algirdas Sackus, Asta Zukauskaite
Summary: A library of 3-aryl-3-azetidinyl acetic acid methyl ester derivatives was synthesized and evaluated for neuroprotective activity in salsolinol- and glutamate-induced neurodegeneration models. Compound 28 showed the highest neuroprotective effect, which may be driven by reductions in oxidative stress and caspase-3/7 activity.
ARCHIV DER PHARMAZIE
(2023)
Article
Neurosciences
Xian-kun Tu, Ping-ping Chen, Jing-yi Chen, Yi-hang Ding, Quan Chen, Song-sheng Shi
Summary: Liraglutide has been discovered to have neuroprotective effects by crossing the blood-brain barrier, but its mechanisms in protecting against ischemic stroke are not well understood. This study investigated the role of GLP-1R in regulating the protective effect of liraglutide in ischemic stroke. The results showed that liraglutide protected the brain tissues of rats by reducing brain edema, infarct volume, neurological deficits, neuronal apoptosis, and increasing the number of live neurons. However, knocking down GLP-1R abolished the protective effects of liraglutide in rats with ischemic stroke.
Review
Cardiac & Cardiovascular Systems
Bruno Verges, Victor Aboyans, Denis Angoulvant, Pierre Boutouyrie, Bertrand Cariou, Fabien Hyafil, Kamel Mohammedi, Pierre Amarenco
Summary: This review summarizes the potential mechanisms by which glucagon-like peptide-1 receptor agonists (GLP-1RAs) provide stroke protection in patients with diabetes. GLP-1RAs show multiple anti-atherosclerotic effects and reduce traditional stroke risk factors. Additionally, GLP-1RAs demonstrate direct cerebral effects in animal stroke models, promoting neurogenesis and reducing infarct volume.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Luis Felipe Hernandez-Ayala, Eduardo Gabriel Guzman-Lopez, Annia Galano
Summary: Quinoline and its derivatives have been shown to have diverse biological activities. In this study, 8536 quinoline derivatives were designed and screened using the CADMA-Chem protocol. The selected derivatives were further investigated for their acid-base, antioxidant and neuroprotective properties. The results indicate that some derivatives exhibit promising antioxidant and neuroprotective activities, making them potential candidates for the treatment of Alzheimer's and Parkinson's diseases.
Review
Pharmacology & Pharmacy
Jessica Silva dos Santos, Joao Pedro Goncalves Cirino, Patricia de Oliveira Carvalho, Manoela Marques Ortega
Summary: Kaempferol, a flavonoid antioxidant found in fruits and vegetables, has shown neuroprotective effects in the central nervous system through modulation of proinflammatory signaling pathways. The differences in biological benefits and pharmacokinetic behaviors between KPF aglycone and its glycosides are notable. Future studies are needed to clarify the mechanisms of Kaempferol's action in CNS diseases and the impact of glycosylation on its bioactivity.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Physiology
Francesco Fischetti, Luca Poli, Marina De Tommaso, Damiano Paolicelli, Gianpiero Greco, Stefania Cataldi
Summary: Physical activity has been shown to reduce the risk of developing non-communicable diseases, including neurodegenerative diseases, but the mechanisms involved are not fully understood. Recent research suggests that extracellular vesicles, which carry microRNAs, may play a role in mediating the beneficial effects of exercise on preventing and slowing neurodegenerative diseases. However, more studies are needed to understand how different exercise parameters may affect these vesicles and the microRNAs they carry.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Behavioral Sciences
Sonalika Bhalla, Sidharth Mehan, Andleeb Khan, Muneeb U. Rehman
Summary: Insulin-like growth factor-1 (IGF-1) and glucagon-like peptide-1 (GLP-1) play crucial roles in CNS development and protection. They prevent neuronal death and promote neuronal function through modulation of various cellular signaling pathways, making them potential therapeutic targets for neurodegenerative diseases.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Shin Jie Yong, Abhimanyu Veerakumarasivam, Wei Ling Lim, Jactty Chew
Summary: Recent research on lactoferrin has revealed its multifunctional roles as an antimicrobial protein, immunomodulatory agent, anticancer agent, and neuroprotective agent. This literature review focuses on lactoferrin's neuroprotective effects and mechanisms against Alzheimer's and Parkinson's diseases, highlighting the involvement of various cellular pathways and proteins. It also discusses the inconsistent findings related to the neuroprotective effects of lactoferrin against Alzheimer's disease.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Behavioral Sciences
Candan Yasemin Eren-Yazicioglu, Arya Yigit, Ramazan Efe Dogruoz, Hale Yapici-Eser
Summary: GLP-1 plays a crucial role in the reward pathways by modulating dopamine levels and glutamatergic neurotransmission, resulting in observed behavioral changes. It has shown potential efficacy in reducing food cravings, substance abuse, and improving activity deficits related to food anticipation in obese patients with diabetes. More translational research is required to further evaluate its impact on human reward system related disorders.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Busra Izgi, Tyler M. Moore, Merve Yalcinay-Inan, Allison M. Port, Kemal Kuscu, Ruben C. Gur, Hale Yapici Eser
Summary: The Turkish version of the Penn Computerized Neurocognitive Battery (PennCNB) demonstrates good test-retest reliability, making it a valuable tool for research and clinical practice, with consideration needed for practice effects when used in short intervals. Significant improvements in retest performances may reflect non-linear learning in memory tests or increased insight in problem-solving tasks.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Oncology
Cemil Burak Kulle, Ibrahim Fethi Azamat, Dogan Vatansever, Suat Erus, Kayhan Tarim, Goktug Akyoldas, Ozan Gokler, Mehmet Ali Deveci, Nahit Cakar, Onder Ergonul, Orhan Agcaoglu, Murat Can Kiremit, Omer Yavuz, Talat Kiris, Selin Unsaler, Burak Giray, Murat Korkmaz, Ece Dilege, Mert Kilic, Ezgi Cesur, Ihsan Solaroglu, Ozan Altuntas, Aykin Simsek, Serhan Tanju, Mert Erkan, Erdem Canda, Mehdi Sasani, Aysenur Meric Hafiz, Yakup Kordan, Emre Balik, Orhan Bilge, Dursun Bugra, Cagatay Taskiran, Sukru Dilege
Summary: The study evaluated the feasibility and short-term clinical outcomes of cancer surgeries at an institution using a COVID-19-free surgical pathway during the peak phase of the pandemic. Results indicated that under strict institutional policies, elective and emergency cancer operations can be performed with acceptable perioperative and postoperative morbidity and mortality rates.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ahmet Cingoz, Ezgi Ozyerli-Goknar, Tunc Morova, Fidan Seker-Polat, Myvizhi Esai Selvan, Zeynep Hulya Gumus, Deepak Bhere, Khalid Shah, Ihsan Solaroglu, Tugba Bagci-Onder
Summary: The study identified acquired TRAIL resistance models in glioblastoma cells and showed that proteasome inhibitor Bortezomib can effectively overcome TRAIL resistance by upregulating death receptors and pro-apoptotic proteins. Inhibition of the NF-kappa B pathway increased sensitivity to TRAIL in the most resistant cells. The findings suggest the critical importance of combining proteasome inhibitors and pro-apoptotic ligands to overcome acquired resistance.
Article
Pharmacology & Pharmacy
Candan Yasemin Eren-Yazicioglu, Buket Kara, Seda Sancak, Sanem Pinar Uysal, Dilek Yazici, Nalan Okuroglu, Alexis E. Whitton, Ashleigh Rutherford, Hale Yapici-Eser
Summary: This study compared obese T2DM patients in terms of cognitive and affective functioning, finding that patients on exenatide treatment had higher BMI, PHQ-9, and PSS scores, while other measures showed no significant differences.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Hale Yapici-Eser, Merve Yalcinay-Inan, Mehmet Utku Kucuker, Can Misel Kilciksiz, Sezen Yilmaz, Neris Dincer, Ozge Kilic, Alaattin Cenk Ercan, Omer Aydemir
Summary: Cognitive function is a core feature related to all psychiatric disorders. Self-report scales of cognitive function may not always correlate with objective measures, and anxiety may affect both self-report and objective measurement of cognitive function while depressive thought content may lead to higher cognitive dysfunction reports in non-demented individuals.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Review
Clinical Neurology
Mirko Manchia, Anouk W. Gathier, Hale Yapici-Eser, Mathias Schmidt, Dominique de Quervain, Therese van Amelsvoort, Jonathan Bisson, John F. Cryan, Oliver D. Howes, Luisa Pinto, Nic J. Van der Wee, Katharina Domschke, Igor Branchi, Christiaan H. Vinkers
Summary: The global public health crisis caused by COVID-19 has had a lasting impact on mental health, with most individuals showing surprising resilience and quick recovery from the pandemic measures. However, vulnerable groups that have been severely impacted by the pandemic still exist, highlighting the need for more comprehensive and integrative assessments of resilience, as well as personalized help and interventions tailored to specific needs for vulnerable groups in future pandemics.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Behavioral Sciences
Sumeyra Saatci Yurtsever, Ozgur Oztop Cakmak, Hale Yapici Eser, Sibel Ertan, O. Ece Demir-Lira, Tilbe Goksun
Summary: This study found that individuals with Parkinson's Disease have impairments in the use and understanding of language gestures, particularly in figurative actions. The severity of their disease was negatively correlated with their performance in matching figurative novel verbs with gestures.
Review
Oncology
Fidan Seker-Polat, Nareg Pinarbasi Degirmenci, Ihsan Solaroglu, Tugba Bagci-Onder
Summary: Glioblastoma is an extremely aggressive and invasive primary brain tumor with poor prognosis. Understanding the molecular mechanisms of glioblastoma invasion and developing new therapeutic approaches are of utmost importance. Efforts have been made to uncover the routes followed by glioblastoma cells, their interaction with the brain environment and extracellular matrix, and the role of cell adhesion and extracellular matrix remodeling. However, there is currently no approved therapy targeting the invasive phenotype.
Article
Clinical Neurology
Ignatius Ngene Esene, Ahmed Negida, Chidiebere S. Ibe, Ulrick S. Kanmounye, Nqobile Thango, Luxwell Jokonya, Samer S. Hoz, Gilbert Dechambenoit, Kazadi K. N. Kalangu, Ihsan Solaroglu
Summary: This article discusses the application and advantages and disadvantages of observational study designs in neurosurgery, focusing on the differences between case reports, case series, cohort, cross-sectional, and case-control studies. The authors emphasize the importance of proper use and reporting in observational study designs.
WORLD NEUROSURGERY
(2022)
Article
Biochemistry & Molecular Biology
Nareg Pinarbasi-Degirmenci, Ilknur Sur-Erdem, Vuslat Akcay, Yasemin Bolukbasi, Ugur Selek, Ihsan Solaroglu, Tugba Bagci-Onder
Summary: By applying fractionated radiotherapy over a long time and selecting irradiation-survivor glioblastoma cells, clinically relevant irradiation-exposed models were generated. The cells exhibited slower growth, resistance to secondary irradiation, upregulation of DDR-related genes, and better DNA repair capacity. The utility of combining DDR inhibitors and irradiation was demonstrated for both naive and IR-Surv glioblastoma cells, as long as cells are refrained from hypoxic conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Alisan Kayabolen, Ugur Akcan, Dogancan Ozturan, Hivda Ulbegi-Polat, Gizem Nur Sahin, Nareg Pinarbasi-Degirmenci, Canan Bayraktar, Gizem Soyler, Ehsan Sarayloo, Elif Nurtop, Berna Ozer, Gulen Guney-Esken, Tayfun Barlas, Ismail Selim Yildirim, Ozlem Dogan, Sercin Karahuseyinoglu, Nathan A. Lack, Mehmet Kaya, Cem Albayrak, Fusun Can, Ihsan Solaroglu, Tugba Bagci-Onder
Summary: Multimeric sACE2 demonstrates high neutralization efficiency and is a promising treatment approach against SARS-CoV-2 infections, surpassing the potency of monomeric sACE2 and effectively neutralizing variants of concern.
Meeting Abstract
Oncology
Irem Yenidogan, Nesibe Peker, Bera Aygun, Gamze Deveci, Dondu Kirmizi, Fikret Asarcikli, Banu Oflaz Sozmen, Goktug Akyoldas, Ibrahim Kulac, Ihsan Solaroglu, Fatih Erbey, Devrim Gozuacik
PEDIATRIC BLOOD & CANCER
(2022)
Proceedings Paper
Engineering, Biomedical
Buse Bilgin, Hulya Torun, Muslum Ilgu, Cenk Yanik, Numan Batur, Suleyman Celik, Meric Ozturk, Ozlem Dogan, Onder Ergonul, Ihsan Solaroglu, Fusun Can, Mehmet Cengiz Onbasli
Summary: In this study, a surface-enhanced Raman spectroscopy (SERS) metasurface optimized with genetic algorithm (GA) was developed to detect SARS-CoV-2 directly using unprocessed saliva samples. After validation of system performance, the SERS substrate was tested with inactivated SARS-CoV-2 virus for virus detection, viral load analysis, cross-reactivity, and variant detection using machine learning models. With 36 PCR positive and 33 negative clinical samples, SARS-CoV-2 positive samples were detected from Raman spectra with 95.2% sensitivity and specificity.
BIOMEDICAL VIBRATIONAL SPECTROSCOPY 2022: ADVANCES IN RESEARCH AND INDUSTRY
(2022)
Proceedings Paper
Engineering, Biomedical
Hulya Torun, Numan Batur, Buse Bilgin, Omer Tarik Esengur, Kemal Baysal, Ibrahim Kulac, Ihsan Solaroglu, Mehmet Cengiz Onbasli
Summary: Clinical test results of Raman spectroscopy and machine learning-based glioblastoma identification methodology were reported. The study found that Raman spectroscopy can distinguish glioblastoma from white matter tissues, and machine learning classifiers achieved accurate classification.
MULTISCALE IMAGING AND SPECTROSCOPY III
(2022)
