Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration

Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration

(2018) Veronica Ghiglieri et al.   Frontiers in Neurology

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy

(2017) Brian Spencer et al.   Acta Neuropathologica Communications

Alpha-Synuclein Produces Early Behavioral Alterations via Striatal Cholinergic Synaptic Dysfunction by Interacting With GluN2D N -Methyl-D-Aspartate Receptor Subunit

(2016) Alessandro Tozzi et al.   BIOLOGICAL PSYCHIATRY

Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease

(2016) Nour K. Majbour et al.   Molecular Neurodegeneration

Synucleinopathies: past, present and future

(2016) M. G. Spillantini et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Balancing the basal ganglia circuitry: A possible new role for dopamine D2 receptors in health and disease

(2015) Maxime Cazorla et al.   MOVEMENT DISORDERS

Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology

(2015) Nishant N. Vaikath et al.   NEUROBIOLOGY OF DISEASE

NMDA receptor GluN2A/GluN2B subunit ratio as synaptic trait of levodopa-induced dyskinesias: from experimental models to patients

(2015) Manuela Mellone et al.   Frontiers in Cellular Neuroscience

Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation

(2015) Dhiman Ghosh et al.   Scientific Reports

Input- and Cell-Type-Specific Endocannabinoid-Dependent LTD in the Striatum

(2015) Yu-Wei Wu et al.   Cell Reports

Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease

(2015) Scarlet Gallegos et al.   Frontiers in Neuroscience

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

(2014) Edward Rockenstein et al.   BRAIN

Direct and indirect pathways of basal ganglia: a critical reappraisal

(2014) Paolo Calabresi et al.   NATURE NEUROSCIENCE

Concurrent activation of striatal direct and indirect pathways during action initiation

(2013) Guohong Cui et al.   NATURE

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

N-Methyl-d-aspartate (NMDA) Receptor Composition Modulates Dendritic Spine Morphology in Striatal Medium Spiny Neurons

(2012) Csaba Vastagh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholinergic Dysfunction Alters Synaptic Integration between Thalamostriatal and Corticostriatal Inputs in DYT1 Dystonia

(2012) G. Sciamanna et al.   JOURNAL OF NEUROSCIENCE

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

(2012) M. J. Diogenes et al.   JOURNAL OF NEUROSCIENCE

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

In vivo Large-Scale Cortical Mapping Using Channelrhodopsin-2 Stimulation in Transgenic Mice Reveals Asymmetric and Reciprocal Relationships between Cortical Areas

(2012) Diana H. Lim et al.   Frontiers in Neural Circuits

Modulation of Striatal Projection Systems by Dopamine

(2011) Charles R. Gerfen et al.   Annual Review of Neuroscience

Thalamic Contributions to Basal Ganglia-Related Behavioral Switching and Reinforcement

(2011) Y. Smith et al.   JOURNAL OF NEUROSCIENCE

Pathological roles of α-synuclein in neurological disorders

(2011) Kostas Vekrellis et al.   LANCET NEUROLOGY

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical and Thalamic Innervation of Direct and Indirect Pathway Medium-Sized Spiny Neurons in Mouse Striatum

(2010) N. M. Doig et al.   JOURNAL OF NEUROSCIENCE

Seven problems on the basal ganglia

(2008) Atsushi Nambu   CURRENT OPINION IN NEUROBIOLOGY

Corticostriatal and Thalamostriatal Synapses Have Distinctive Properties

(2008) J. Ding et al.   JOURNAL OF NEUROSCIENCE

Metabotropic Glutamate Receptors 5 Blockade Reverses Spatial Memory Deficits in a Mouse Model of Parkinson's Disease

(2008) Elvira De Leonibus et al.   NEUROPSYCHOPHARMACOLOGY

Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity

(2008) W. Shen et al.   SCIENCE