期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 29, 期 14, 页码 1765-1768出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2019.05.016
关键词
Feline immunodeficiency virus (FIV); Human immunodeficiency virus (HIV); Selenium; Zinc ejection; Nucleocapsid protein
资金
- University of Zurich, Switzerland
- Biocenter Finland/DDCB, Finland
- Russian Science Foundation, Russian Federation [15-13-10022]
- Russian Science Foundation [18-13-17000] Funding Source: Russian Science Foundation
We report the first biological evaluation the 1,2,3-thiaselenazole class of compound and utilising a concise synthetic approach of sulfur extrusion, selenium insertion of the 1,2,3-dithiazoles. We created a small diverse library of compounds to contrast the two ring systems. This approach has highlighted new structure activity relationship insights and lead to the development of sub-micro molar anti-viral compounds with reduced toxicity. The 1,2,3-thiaselenazole represents a new class of potential compounds for the treatment of FIV and HIV.
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