期刊
BIOMEDICAL ENGINEERING ONLINE
卷 18, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12938-019-0654-1
关键词
Weight-bearing; Moderate intensity; Treadmill exercise; Bone quality
资金
- National Natural Science foundation of China [11872095, 11702110, 11432016]
- Science and Technology Department of Jilin Province [20170519008JH, 20170520093JH]
BackgroundBone tissue displays a hierarchical organization. Mechanical environments influence bone mass and structure. This study aimed to explore the effects of different mechanical stimuli on growing bone properties at macro-micro-nano scales.MethodsSixtyfive-week-old female Wistar rats were treadmill exercised at moderate intensity with the speed of 12m/min, and then randomly divided into five groups according to weight-bearing level. After 8weeks of experiment, femurs were harvested to perform multiscale tests.ResultsBone formation was significantly increased by weight-bearing exercise, whereas bone resorption was not significantly inhibited. Trabecular and cortical bone mineral densities showed no significant increase by weight-bearing exercise. The microstructure of trabecular bone was significantly improved by 12% weight-bearing exercise. However, similar positive effects were not observed with further increase in weight-bearing levels. The nanomechanical properties of trabecular bone were not significantly changed by weight-bearing exercise. The macrostrength of whole femur and the nanomechanical properties of cortical bone significantly decreased in the 19% and 26% weight-bearing exercise groups.ConclusionWhen rats ran on the treadmill at moderate intensity during growth period, additional 12% weight-bearing level could significantly increase bone formation, improve microstructure of trabecular bone, as well as maintain the structure and mechanical properties of cortical bone. Excessive weight-bearing level caused no positive effects on the trabecular bone microstructure and properties of cortical bone at all scales. In addition, increased weight-bearing level exerted no significant influence on trabecular and cortical bone mineral densities.
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