Article
Materials Science, Multidisciplinary
Yushan Zhang, Chandra Kumar Elechalawar, Wen Yang, Alex N. Frickenstein, Sima Asfa, Kar-Ming Fung, Brennah N. Murphy, Shailendra K. Dwivedi, Geeta Rao, Anindya Dey, Stefan Wilhelm, Resham Bhattacharya, Priyabrata Mukherjee
Summary: The communication among cancer cells, cancer associated fibroblasts, and endothelial cells in the tumor microenvironment plays a crucial role in the poor prognosis of many cancers. This study using epithelial ovarian cancer as a model demonstrated that co-culturing these cell types promotes cancer cell proliferation, migration, and invasion. Disrupting this multicellular communication using gold nanoparticles inhibits tumor growth by reducing expression of tumor-promoting cytokines and growth factors.
Review
Medicine, Research & Experimental
Ali Baradaran, Zahra Asadzadeh, Nima Hemmat, Amir Baghbanzadeh, Mahdi Abdoli Shadbad, Neda Khosravi, Afshin Derakhshani, Hajar Alemohammad, Mina Afrashteh Nour, Hossein Safarpour, Nicola Silvestris, Oronzo Brunetti, Behzad Baradaran
Summary: TAMs play important roles in the tumor microenvironment, contributing to tumor development, chemoresistance, immune evasion, and metastasis. The interaction between TAMs and tumoral endothelial cells has a significant impact on tumor angiogenesis and immune evasion. Therefore, targeting TAMs and their interaction could be a promising strategy for improving cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Md Nazir Hossen, Lin Wang, Shailendra Kumar Dhar Dwivedi, Yushan Zhang, Geeta Rao, Chandra Kumar Elechalwar, Vinit Sheth, Anindya Dey, Sima Asfa, Suresh Kumar Gulla, Chao Xu, Kar-Ming Fung, J. David Robertson, Magdalena Bieniasz, Stefan Wilhelm, Resham Bhattacharya, Priyabrata Mukherjee
Summary: By utilizing the self-therapeutic properties of gold nanoparticles, researchers identified a molecular axis that promotes the growth of ovarian cancer and validated its potential for inhibiting tumor growth.
Article
Multidisciplinary Sciences
Joshua D. D. Hall, Sina Farzaneh, Reza Babakhani Galangashi, Akshay Pujari, Daniel T. T. Sweet, Mark L. L. Kahn, Juan M. M. Jimenez
Summary: Lymphoedema causes diminished contraction of lymphatic vessels, resulting in quasi-steady lymph flow and increased intercellular gap formation in lymphatic endothelial cells. Steady pressure increases intercellular gap formation, while pulsatile pressure does not. These studies reveal that the loss of pulsatility leads to an increase in intercellular gap formation mediated by MLC phosphorylation.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Review
Biochemistry & Molecular Biology
Rindert Missiaen, Nicholas P. Lesner, M. Celeste Simon
Summary: The role of hypoxia-inducible factors (HIFs) in regulating tumor cell metabolism under hypoxia has been extensively studied, but their role in regulating nutrient fates in tumor and stromal cells is not well understood. HIF and nutrients in the tumor microenvironment (TME) can influence the metabolism of stromal and immune cells, as well as tumor cells. This review discusses how HIF-mediated mechanisms regulate nutrient sensing and availability in the TME, the competition for nutrients, and the metabolic crosstalk between tumor and stromal cells.
Review
Immunology
Gloria Orlando, Barbara Molon, Antonella Viola, Mauro Alaibac, Roberta Angioni, Stefano Piaserico
Summary: Psoriasis is a chronic inflammatory skin disease associated with various comorbidities, including cardiovascular diseases. Current research focuses on the pathways linking psoriatic plaques to the cardiovascular system, as well as the potential involvement of endothelial cells in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Umesh Ghoshdastider, Neha Rohatgi, Marjan Mojtabavi Naeini, Probhonjon Baruah, Egor Revkov, Yu Amanda Guo, Simone Rizzetto, Angeline M. L. Wong, Sundar Solai, Tin T. Nguyen, Joe Poh Sheng Yeong, Jabed Iqbal, Puay Hoon Tan, Balram Chowbay, Ramanuj Dasgupta, Anders J. Skanderup
Summary: This study deconvoluted bulk tumor transcriptomes across multiple cancer types to infer cross-talk in the tumor microenvironment. The results show that signaling between cancer and stromal cells varies between tissues, and there are high levels of interactions at immune checkpoints across different tumor types.
Review
Cell Biology
Priscilla W. Tang, Leonard Frisbie, Nadine Hempel, Lan Coffman
Summary: This review examines the metabolic characteristics of cellular components in the tumor microenvironment of ovarian cancer, with a focus on the metabolic interactions between stromal cells and tumor cells, as well as the impact of stromal and tumor cell metabolites on intratumoral immune cell metabolism and function. The findings highlight the significant influence of TME metabolism on cancer progression, emphasizing the need for further research and therapeutic development.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Alexander Tacey, Alan Hayes, Anthony Zulli, Itamar Levinger
Summary: Current research on the interaction between OC and vascular function has produced conflicting results in humans, with some studies showing an association between total OC and vascular function while others do not. Animal studies indicate that direct administration of ucOC to blood vessels has minimal impact on endothelial function and no adverse effects. In vitro studies on human endothelial and vascular smooth muscle cells also suggest that ucOC treatment does not negatively influence cellular function, indicating a potential future therapeutic target for metabolic diseases.
MOLECULAR METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Amanda J. Oliver, Phillip K. Darcy, Joseph A. Trapani, Michael H. Kershaw, Clare Y. Slaney
Summary: Cancer tissue is heterogeneous and tumor microenvironment cells can communicate with each other to influence their function. Moreover, tumors located remotely from each other can engage in cross-talk that can influence their responsiveness to various therapies. Communication between cancer cells and immune cells can lead to immunosuppression.
Review
Pharmacology & Pharmacy
Cong Xia, Yantao Cai, Shuangyi Ren, Chenglai Xia
Summary: The human gut microbiota plays a significant role in the development and progression of colorectal cancer, and manipulating the gut microbiota could be a novel approach for prevention and treatment. Specific bacteria have been found to have anti-tumor activity and can improve the tumor microenvironment by activating immune cells and upregulating the secretion of pro-tumor immune cytokines. This paper summarizes the potential benefits of certain bacteria in colorectal cancer, highlights their roles in the tumor microenvironment, discusses the application of gut microbes in combination with immunosuppressive agents, and provides suggestions for further experimental studies and clinical practice applications.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Silvia Cadenas-De Miguel, Giulia Lucianer, Ilaria Elia
Summary: The metabolic interaction between cancer cells and T cells plays a crucial role in cancer formation and progression. Cancer cells possess metabolic plasticity and adapt their metabolism to meet their specific needs. However, the nutrient-deprived tumor microenvironment forces these cells to compete for limited resources. The hyperactive metabolism of tumor cells often suppresses the immune response while promoting tumor-promoting T cells, leading to uncontrolled cancer growth. Identification of metabolic pathways that shift the immune phenotype from pro-tumorigenic to anti-tumorigenic is essential for enhancing anti-tumor immunity.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Review
Immunology
Johanna Bodder, Tasmin Zahan, Rianne van Slooten, Gerty Schreibelt, I. Jolanda M. de Vries, Georgina Florez-Grau
Summary: Immunotherapeutic approaches have revolutionized the treatment of diseases like cancer, with a focus on modulating anti-tumor immune responses. Natural killer (NK) cells and dendritic cells (DCs) play crucial roles in cancer immunotherapy, and their bidirectional cross-talk within the tumor microenvironment is essential for treatment success.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Nadia Meyer, Lars Brodowski, Katja Richter, Constantin S. von Kaisenberg, Bianca Schroeder-Heurich, Frauke von Versen-Hoeynck
Summary: Pravastatin enhances the functional capacities of ECFCs and promotes angiogenic signaling and protein expression, improving endothelial health. These effects may offer a promising option for ameliorating endothelial dysfunction and understanding the pleiotropic function of statins.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Lena Batoon, Laurie K. McCauley
Summary: The skeleton is a common site for cancer metastases due to the bone microenvironment providing conditions for cancer cell colonization. Tumor associated macrophages (TAMs) play a critical role in regulating tumorigenicity in multiple cancers, but their interactions with cancer cells in bone metastases are not fully understood. Studying these interactions may provide insights into the mechanisms of bone metastases and potential therapeutic targets for inhibiting disease progression.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Chandra Kumar Elechalawar, Md Nazir Hossen, Priya Shankarappa, Cody J. Peer, William D. Figg, J. David Robertson, Resham Bhattacharya, Priyabrata Mukherjee
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Review
Chemistry, Multidisciplinary
Chandra Kumar Elechalawar, Md Nazir Hossen, Lacey McNally, Resham Bhattacharya, Priyabrata Mukherjee
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Multidisciplinary Sciences
Md Nazir Hossen, Lin Wang, Harisha R. Chinthalapally, Joe D. Robertson, Kar-Ming Fung, Stefan Wilhelm, Magdalena Bieniasz, Resham Bhattacharya, Priyabrata Mukherjee
Article
Multidisciplinary Sciences
Anindya Dey, Shubhangi Prabhudesai, Yushan Zhang, Geeta Rao, Karthikeyan Thirugnanam, Md Nazir Hossen, Shailendra Kumar Dhar Dwivedi, Ramani Ramchandran, Priyabrata Mukherjee, Resham Bhattacharya
Review
Chemistry, Multidisciplinary
Joshua Seaberg, Hossein Montazerian, Md Nazir Hossen, Resham Bhattacharya, Ali Khademhosseini, Priyabrata Mukherjee
Summary: Inorganic/organic hybrid nanosystems have been increasingly developed for their versatility and efficacy in biomedical applications, including gene therapy, drug delivery, and phototherapy. They can be classified based on their components and architecture, showing potential for diverse utility and innovation in the future.
Article
Oncology
Md. Nazir Hossen, Chandra Kumar Elechalawar, Virginie Sjoelund, Kathleen Moore, Robert Mannel, Resham Bhattacharya, Priyabrata Mukherjee
Summary: This study aimed to identify potential new molecular target proteins (NMTPs) responsible for poor outcomes in ovarian cancer. The results showed that pre-processing conditions can alter the protein corona (PC) composition and enhance the identification of NMTPs.
CANCER NANOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Yushan Zhang, Chandra Kumar Elechalawar, Md Nazir Hossen, Emmy R. Francek, Anindya Dey, Stefan Wilhelm, Resham Bhattacharya, Priyabrata Mukherjee
Summary: Research has shown that ovarian cancer cells and TME cells promote the activation of ovarian CAFs, while 20 nm gold nanoparticles inhibit this activation, potentially serving as a strategy to disrupt cellular communication in the TME.
BIOACTIVE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Nicolas Means, Chandra Kumar Elechalawar, Wei R. Chen, Resham Bhattacharya, Priyabrata Mukherjee
Summary: This review focuses on the less studied endocytosis mechanism of macropinocytosis and discusses the endocytosis of nanoparticles, including macropinocytosis. It explores how the physio-chemical properties of nanoparticles affect their intracellular uptake and their potential as tools for identifying new adapter molecules regulating these processes.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
William M. MacCuaig, Benjamin L. Fouts, Molly W. McNally, William E. Grizzle, Phillip Chuong, Abhilash Samykutty, Priyabrata Mukherjee, Min Li, Jacek B. Jasinski, Bahareh Behkam, Lacey R. McNally
Summary: Active targeting using V7 peptide is superior to nanoparticle size in tumor uptake, with size having a secondary effect on actively targeted nanoparticles. Passive targeting nanoparticles showed no significant effect of size on uptake.
ACS APPLIED MATERIALS & INTERFACES
(2021)