期刊
BIOCONJUGATE CHEMISTRY
卷 30, 期 6, 页码 1658-1664出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.9b00128
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资金
- Natural Science Foundation of China [21778009, 81701818]
- Shenzhen Science and Technology Innovation Committee [JCYJ20170807144449135, JCYJ20170412150609690, KQJSCX20170728101942700]
- High-Performance Computing Platform of Peking University
Black phosphorus (BP) is a two-dimensional (2D) nanomaterial with high charge-carrier mobility, a tunable direct bandgap, and a unique in-plane anisotropic structure; however, the easiness of BP oxidation into PxOy species in ambient conditions largely limits its applications. In this study, modified cisplatin-Pt-NO3 [Pt-(NH3)(2)(NO3)(2)] is used for surface coordination with BP nanosheets to generate Pt@BP, which maintains the surface morphology and properties of BP nanosheets for more than 24 h in ambient conditions. In addition, Pt@BP interacts with DNA both in vitro and in cell. Pt@BP shows a good cellular uptake rate and significantly increases the drug sensitivity of cisplatin-resistant cancer cell lines (A2780 and HepG2) compared with unmodified cisplatin. Our study is the first attempt to stabilize bare BP with cationic cisplatin species, and the generated Pt@BP could be used for potential synergistic photothermal/chemotherapy of cisplatin-resistant cancer.
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