期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1867, 期 3, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbamcr.2019.03.012
关键词
tRNA; Heart; Cardiomyocyte; Skeletal muscle; tRNA-derived small RNA; tRNA synthetases
资金
- Netherlands Heart Foundation [Dekker 2014T105]
- Netherlands Heart Foundation (CVON-SHE-PREDICTS-HF)
- Netherlands Organisation for Scientific Research (NWO) [vidi 917.14.363]
- Health Foundation Limburg
- ERA-CVD Joint International Call grant (Netherlands Heart Foundation) [2016T091]
- ERA-CVD Joint International Call grant (NWO-ZonMw) [2016T091]
Transfer RNAs (tRNAs) and their processing enzymes have long-recognized roles in cardiac and skeletal muscle pathophysiology. Recently, tRNA fragments have emerged as a new class of non-coding RNAs involved in the regulation of cell function. In this review, we provide a synopsis of the molecular processes that regulate the biogenesis, post-transcriptional regulation and functional roles of tRNAs in cardiac and skeletal muscle. In addition, we list the (dys)regulated expression profiles and putative functional roles of tRNA-derived small RNAs in the heart and skeletal muscle. Finally, the technical challenges surrounding tRNA research are discussed alongside suggestions to advance research in this field.
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