Review
Oncology
Xiaoyun He, Gaoyan Kuang, Yongrong Wu, Chunlin Ou
Summary: Exosomes are small vesicles secreted by cells and can carry various cargo including RNA, DNA, proteins, and metabolites. Studies have shown that exosomal microRNAs play a crucial role in the progression of diseases such as diabetes mellitus, affecting processes like pancreatic beta-cell injury and insulin resistance. Understanding the mechanisms of exosomal miRNAs in diabetes mellitus can provide valuable insights for identifying diagnostic biomarkers and drug targets.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Soumyalekshmi Nair, Dominic Guanzon, Nanthini Jayabalan, Andrew Lai, Katherin Scholz-Romero, Priyakshi Kalita de Croft, Valeska Ormazabal, Carlos Palma, Emilio Diaz, Elizabeth A. McCarthy, Alexis Shub, Jezid Miranda, Eduard Gratacos, Fatima Crispi, Gregory Duncombe, Martha Lappas, H. David McIntyre, Gregory Rice, Carlos Salomon
Summary: Gestational diabetes mellitus (GDM) poses a significant public health concern, affecting 9-15% of pregnancies worldwide. This study found that EV-associated miRNAs in GDM patients undergo significant changes during gestation and can be effectively used for classification. A set of proteins associated with JAK-STAT signaling in skeletal muscle biopsies from GDM patients was identified, which may be targeted by the miRNA-92a-3p carried by circulating EVs. Overexpression of miRNA-92a-3p was shown to increase insulin sensitivity in primary skeletal muscle cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Seung Yeon Park, Hyun Jung Lee, Jin-Ho Song, Yong Kyoo Shin, A. M. Abd El-Aty, Amer Ramadan, A. Hacimuftuoglu, Ji Hoon Jeong, Tae Woo Jung
Summary: In summary, DITA treatment attenuated palmitate-induced impairment of insulin signaling and inflammation in C2C12 myocytes by enhancing AMPK phosphorylation, PPAR delta expression, and FGF21 secretion. This study suggests that targeting the AMPK/FGF21/PPAR delta pathway may alleviate insulin resistance in skeletal muscle cells.
Article
Cell Biology
Tae Woo Jung, Hyun Jung Lee, Do Hyeon Pyun, Tae Jin Kim, Joon Seok Bang, Jin-Ho Song, Yong Kyoo Shin, A. M. Abd El-Aty, Ji Hoon Jeong
Summary: The study demonstrates that CAP ameliorates insulin resistance in palmitate-treated C2C12 myocytes through the PPAR delta/p38 signaling-mediated suppression of inflammation.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
David Aguilar-Recarte, Xavier Palomer, Walter Wahli, Manuel Vazquez-Carrera
Summary: Activators of PPAR beta/delta show promise in preventing and treating type 2 diabetes mellitus, mainly through AMPK activation. Further understanding of the mechanisms underlying the effects of the PPAR beta/delta-AMPK pathway may provide a basis for the development of new therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Maria Alexandra Angelescu, Octavian Andronic, Simona Olimpia Dima, Irinel Popescu, Irit Meivar-Levy, Sarah Ferber, Daniela Lixandru
Summary: Diabetes mellitus is a complex disease that requires early diagnosis and treatment to prevent complications. MiRNAs have shown promise as biomarkers for early detection and monitoring of the disease. Further research is needed to validate their effectiveness in diagnosing and treating diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Faezeh Malakoti, Erfan Mohammadi, Mahsa Akbari Oryani, Darioush Shanebandi, Bahman Yousefi, Azadeh Salehi, Zatollah Asemi
Summary: MiRNAs play a role in the occurrence and development of diabetic complications by interacting with mRNA to prevent translation, and polyphenols are considered safe drugs for treating diabetic complications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Nutrition & Dietetics
Yujeong Kim, Ok-Kyung Kim
Summary: Recent research has shown that extracellular microRNAs from adipose tissue are involved in the development of insulin resistance. Certain miRNAs, such as miR-27a, miR-34a, miR-141-3p, miR-155, miR210, and miR-222, secreted from adipose tissue can impact the insulin signaling pathway in metabolic tissue, contributing to conditions like obesity and type 2 diabetes. Understanding the roles of these miRNAs may offer potential for developing therapeutics for obesity and metabolic disorders.
ADVANCES IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
V. B. Sameer Kumar, K. Anjali
Summary: One of the major reasons for the non-effectiveness of anticancer therapeutics targeting tumour angiogenesis is the complexity of cellular communication in the tumour micro-environment. Recent research has highlighted the importance of signaling events mediated by exosomes in tumor progression and angiogenesis. This review collates information on the role of exosomal cargo, especially exosomal miRNAs, in modulating tumor angiogenesis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Multidisciplinary Sciences
Carmen Pheiffer, Stephanie Dias, Amy E. Mendham, Babalwa Jack, Tarryn Willmer, Nasr Eshibona, Hocine Bendou, Ashley Pretorius, Julia H. Goedecke
Summary: This study investigated the changes in miRNA expression in gluteal subcutaneous adipose tissue (GSAT) of South African women with obesity after a 12-week exercise intervention. The results showed that exercise training significantly increased the expression of miR-155-5p, miR-329-3p, and miR-377-3p in GSAT, but not in abdominal subcutaneous adipose tissue (ASAT). A novel miRNA, MYN0617, with low expression in ASAT was also identified in GSAT. The exercise-induced differences in miRNA expression were correlated with each other and associated with changes in high-density lipoprotein concentrations.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Carmen Pheiffer, Stephanie Dias, Amy E. Mendham, Babalwa Jack, Tarryn Willmer, Nasr Eshibona, Hocine Bendou, Ashley Pretorius, Julia H. Goedecke
Summary: This study aimed to investigate the expression of miRNAs in adipose tissue in response to exercise intervention in women with obesity. The results showed that exercise training increased the expression of certain miRNAs in gluteal subcutaneous adipose tissue (GSAT) but not in abdominal subcutaneous adipose tissue (ASAT). A novel miRNA, MYN0617, was also identified in GSAT. The exercise-induced changes in miRNA expression were associated with each other and with changes in high-density lipoprotein concentrations.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Jaime Delgadillo-Velazquez, Herminia Mendivil-Alvarado, Carlos Daniel Coronado-Alvarado, Humberto Astiazaran-Garcia
Summary: Extracellular vesicles (EVs) secreted by cells, particularly adipose tissue-derived EVs (ADEVs), may contribute to inflammatory responses and the development of metabolic diseases associated with obesity.
Review
Oncology
America Campos, Shayna Sharma, Andreas Obermair, Carlos Salomon
Summary: The article discusses the association between miRNAs within extracellular vesicles (EVs) and chemotherapy resistance, identifying certain miRNAs in various cancers linked to chemoresistance. Studies suggest that miR-21, miR-222, and miR-155 have roles in response to chemotherapy in different types of tumors.
Article
Pharmacology & Pharmacy
Mengying Niu, Hong Li, Xu Li, Xiaoqian Yan, Aijun Ma, Xudong Pan, Xiaoyan Zhu
Summary: This study identified four promising exosomal miRNAs associated with large-artery atherosclerosis (LAA) stroke, the most common subtype of ischemic stroke, through high-throughput sequencing and qRT-PCR analysis. These miRNAs can serve as diagnostic biomarkers for LAA stroke, showing superior diagnostic efficiency compared to their plasma counterparts.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Organic
Gang Sun, Jing Li, Xin Liu, Yiting Liu, Xiaoan Wen, Hongbin Sun, Qing-Long Xu
Summary: A green method for constructing C-S bonds using sulfonyl chlorides and alcohols/acids via a P-III/P-V=O catalytic system is reported. The organophosphorus-catalyzed umpolung reaction promotes the proposal of a dual-substrate deoxygenation strategy. The method demonstrates the deoxygenation of sulfonyl chlorides and alcohols/acids driven by P-III/P-V=O redox cycling and shows high functional group tolerance, making it applicable for late-stage diversification of drug analogues.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)