Article
Oncology
Dilihumaer Tuluhong, Tao Chen, Jingjie Wang, Huijuan Zeng, Hanjun Li, Wangmu Dunzhu, Qiurong Li, Shaohua Wang
Summary: This study revealed that FZD2 is abundantly expressed in breast cancer tissues, and high levels of FZD2 are significantly correlated with poor prognosis. Silencing of FZD2 suppresses cell growth, migration, and invasion in breast cancer. FZD2 promotes TGF-beta 1-induced EMT process by activating the Notch signaling pathway.
CANCER CELL INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Mehrdokht Sadrkhanloo, Maliheh Entezari, Sima Orouei, Marzieh Ghollasi, Nikoo Fathi, Shamin Rezaei, Elahe Sadat Hejazi, Amirabbas Kakavand, Hamidreza Saebfar, Mehrdad Hashemi, Mohammad Ali Sheikh Beig Goharrizi, Shokooh Salimimoghadam, Mohsen Rashidi, Afshin Taheriazam, Saeed Samarghandian
Summary: Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for tumor metastasis and inhibition of this process improves prognosis. STAT3 signaling is shown to promote EMT-mediated cancer migration and invasion, and its inhibition suppresses cancer metastasis and improves therapy response.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Oncology
Shu Ning, Chengfei Liu, Wei Lou, Joy C. Yang, Alan P. Lombard, Leandro S. D'Abronzo, Neelu Batra, Ai-Ming Yu, Amy R. Leslie, Masuda Sharifi, Christopher P. Evans, Allen C. Gao
Summary: Next-generation antiandrogen drugs improve survival and quality of life in advanced prostate cancer patients, but resistance to these drugs is not well understood. This study found that the Wnt5a/FZD2 signaling pathway plays a critical role in promoting enzalutamide resistance, and targeting this pathway could be a potential therapy for advanced prostate cancer.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
YuJian Xia, Jian Chen, Guangyao Liu, WeiBin Huang, XiaoJing Wei, ZheWei Wei, YuLong He
Summary: The study revealed that STIP1 is highly expressed in CRC tissues and is associated with poor overall survival. STIP1 promotes CRC cell proliferation and invasion through the STAT3 pathway, while its knockdown inhibits these functions. This suggests that STIP1 could be a potential target for CRC therapy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Kelie Chen, Xiaoyu Yuan, Shengchao Wang, Fang Zheng, Zhiqin Fu, Zhangjin Shen, Xiaodong Cheng, Yuwei Wang, Song Tang, Heng Ni, Fang Wang, Guang Lu, Yihua Wu, Dajing Xia, Weiguo Lu
Summary: Peritoneal metastasis is a key feature of advanced ovarian cancer. The protein MAP4K4 was found to be highly expressed in metastatic sites and its increased expression was associated with poorer survival and more advanced stage. Down regulation of MAP4K4 inhibited cancer cell adhesion, migration, and invasion. MAP4K4 was also found to stabilize N-cadherin by suppressing its cleavage, leading to N-cadherin stabilization and promoting ovarian cancer metastasis. Targeting MAP4K4 may be a potential therapeutic approach for ovarian cancer patients.
Article
Biochemistry & Molecular Biology
Xuewei Zhang, Wataru Sakamoto, Daniel Canals, Masumi Ishibashi, Masaya Matsuda, Kentaro Nishida, Masafumi Toyoshima, Shogo Shigeta, Makoto Taniguchi, Can E. Senkal, Toshiro Okazaki, Nobuo Yaegashi, Yusuf A. Hannun, Takeshi Nabe, Kazuyuki Kitatani
Summary: Regulation of sphingolipid metabolism has a significant impact on cellular homeostasis and cancer progression. Dysregulation of ceramide-centered metabolism is associated with metastatic potential in ovarian cancer cells. Specifically, the CerS2-C-24:1-ceramide axis, possibly counteracted by neutral ceramidase, plays a key role in limiting cell motility and metastatic potential.
Article
Biochemistry & Molecular Biology
Dong Suwei, Xiao Yanbin, Wang Jianqiang, Ma Xiang, Peng Zhuohui, Kang Jianping, Wang Yunqing, Li Zhen
Summary: The study reveals that the miR-5100/SPINK5/STAT3 axis promotes melanoma cell metastasis, while metformin can significantly inhibit this pathway and prevent melanoma metastasis.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Zoe K. Price, Noor A. Lokman, Mai Sugiyama, Yoshihiro Koya, Masato Yoshihara, Martin K. Oehler, Hiroaki Kajiyama, Carmela Ricciardelli
Summary: In ovarian cancer cells, the presence of 1000 KDa HA promotes spheroid formation, while downregulated DAB2 is associated with ovarian cancer and exhibits different expression patterns and potential pro-tumorigenic and tumor suppressive functions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Immunology
Huan Yi, Yan-zhao Su, Rong Lin, Xiang-qin Zheng, Diling Pan, Dan-mei Lin, Xiang Gao, Rong Zhang
Summary: The study suggests that high expression of RIPK4 in ovarian cancer is associated with poorer overall survival, and downregulation of RIPK4 can inhibit EMT by suppressing IL-6, providing a new therapeutic target for improving the prognosis of ovarian cancer patients.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jun Se Kim, Min Joo Shin, Seo Yul Lee, Dae Kyoung Kim, Kyung-Un Choi, Dong-Soo Suh, Dayea Kim, Jae Ho Kim
Summary: CD109 is upregulated in doxorubicin-resistant EOC cells and plays a key role in the acquisition of drug resistance by activating the STAT3-NOTCH1 signaling axis. Targeting CD109 and the STAT3-NOTCH1 pathway may provide a new therapeutic strategy to overcome chemotherapy resistance in patients with EOC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Haoran Li, Zihao Qi, Yongdong Niu, Yufei Yang, Mengjiao Li, Yangyang Pang, Mingming Liu, Xi Cheng, Midie Xu, Ziliang Wang
Summary: FBP1 expression is significantly decreased in ovarian cancer tissues and low expression predicts poor prognosis. Enhanced FBP1 expression suppresses cancer cell proliferation and invasion, increases sensitivity to chemotherapy.
Article
Biochemistry & Molecular Biology
Yangjun Wu, Miao Xu, Zheng Feng, Hao Wu, Jingni Wu, Xinyu Ha, Yong Wu, Siyu Chen, Fei Xu, Hao Wen, Shengli Li, Xiaohua Wu
Summary: This study reveals that hsa_circ_0010467 mediates platinum resistance in ovarian cancer through the AUF1/hsa_circ_0010467/miR-637/LIF/STAT3 axis. Silencing hsa_circ_0010467 enhances the efficacy of platinum treatment. This research provides potential targets for the treatment of platinum-resistant ovarian cancer patients.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Oncology
Mourad Assidi
Summary: This study investigates the expression patterns of N-CAD protein in ovarian cancer (OC) patients and its correlations with clinicopathological features. The study finds that N-CAD protein is often overexpressed in OC and its cytoplasmic overexpression is significantly correlated with tumor grade, subtype, necrosis, and age at menarche. Patients with cytoplasmic N-CAD overexpression have a shorter disease-free survival and higher recurrence rate. These findings highlight the poor prognostic role of N-CAD in OC and its involvement in EMT and distant metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Reproductive Biology
Shuo Gao, Wenyuan Zhang, Na Yan, Min Li, Xiaowei Mu, Huaxia Yin, Jinhua Wang
Summary: The study found that high expression of STAT3/p-STAT3 is associated with unfavorable clinicopathologic characteristics and prognosis factors in ovarian cancer. Furthermore, high STAT3/p-STAT3 expression may predict poor prognosis in ovarian cancer patients. However, further prospective trials are needed to confirm these associations.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Pathology
Weijian Zhou, Jie Mei, Dingyi Gu, Junying Xu, Runjie Wang, Huiyu Wang, Chaoying Liu
Summary: Despite the rapid development of novel adjuvant and neoadjuvant chemotherapeutic drugs in recent years, advanced ovarian cancer still lacks effective treatment strategies and remains one of the main causes of death among women. Wnt5a protein expression has been observed to be significantly upregulated in ovarian cancer and associated with poor prognosis. Downregulating Wnt5a levels effectively suppresses ovarian cancer cell migration and invasion abilities, suggesting it as a promising novel therapeutic target for future treatments.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)