Peroxynitrite-Mediated SIRT (Sirtuin)-1 Inactivation Contributes to Nicotine-Induced Arterial Stiffness in Mice

A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

(2019) Chunbo He et al.   Cell Reports

Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease

(2017) Patrick Lacolley et al.   PHYSIOLOGICAL REVIEWS

Extracellular Matrix Disarray as a Mechanism for Greater Abdominal Versus Thoracic Aortic Stiffness With Aging in PrimatesSignificance

(2016) Jie Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mechanisms involved in extracellular matrix remodeling and arterial stiffness induced by hyaluronan accumulation

(2016) Karen Axelgaard Lorentzen et al.   ATHEROSCLEROSIS

Matrix ageing and vascular impacts: focus on elastin fragmentation

(2016) Laurent Duca et al.   CARDIOVASCULAR RESEARCH

Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic AneurysmNovelty and Significance

(2016) Hou-Zao Chen et al.   CIRCULATION RESEARCH

AMP-Activated Protein Kinase Alpha 2 Deletion Induces VSMC Phenotypic Switching and Reduces Features of Atherosclerotic Plaque StabilityNovelty and Significance

(2016) Ye Ding et al.   CIRCULATION RESEARCH

Diabetes and Risk of Arterial Stiffness: A Mendelian Randomization Analysis

(2016) Min Xu et al.   DIABETES

Vascular Smooth Muscle Sirtuin-1 Protects Against Diet-Induced Aortic StiffnessNovelty and Significance

(2016) Jessica L. Fry et al.   HYPERTENSION

Activation of SIRT1 Attenuates Klotho Deficiency–Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase ActivityNovelty and Significance

(2016) Diansa Gao et al.   HYPERTENSION

Longitudinal Association Between Serum Uric Acid and Arterial StiffnessNovelty and Significance

(2016) Marco Canepa et al.   HYPERTENSION

Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure With Preserved Ejection Fraction, and Heart Failure With Reduced Ejection FractionNovelty and Significance

(2016) Ambarish Pandey et al.   HYPERTENSION

Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by CysteineS-Nitrosation

(2016) Kelsey S. Kalous et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP

(2016) Tomomi E. Kimura et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Electronic Cigarette Smoking Increases Aortic Stiffness and Blood Pressure in Young Smokers

(2016) Charalambos Vlachopoulos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Aortic Stiffness and the Risk of Incident Mild Cognitive Impairment and Dementia

(2016) Matthew P. Pase et al.   STROKE

TEMPOL increases NAD+ and improves redox imbalance in obese mice

(2016) Mayumi Yamato et al.   Redox Biology

Segmental Aortic Stiffness in Children and Young Adults With Connective Tissue DisordersCLINICAL PERSPECTIVE

(2015) Ashwin Prakash et al.   CIRCULATION

Segmental Aortic Stiffening Contributes to Experimental Abdominal Aortic Aneurysm Development

(2015) U. Raaz et al.   CIRCULATION

Between Rho(k) and a Hard Place: The Relation Between Vessel Wall Stiffness, Endothelial Contractility, and Cardiovascular Disease

(2015) S. Huveneers et al.   CIRCULATION RESEARCH

Stiff substrates increase YAP-signaling-mediated matrix metalloproteinase-7 expression

(2015) A Nukuda et al.   Oncogenesis

Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates

(2014) Julie A. Mattison et al.   Cell Metabolism

Nicotine Activates YAP1 through nAChRs Mediated Signaling in Esophageal Squamous Cell Cancer (ESCC)

(2014) Yue Zhao et al.   PLoS One

Increased vascular smooth muscle cell stiffness: a novel mechanism for aortic stiffness in hypertension

(2013) Nancy L. Sehgel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Increased Aortic Stiffness and Attenuated Lysyl Oxidase Activity in Obesity

(2013) Ju-Yi Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation and Mechanical Stretch Promote Aortic Stiffening in Hypertension Through Activation of p38 Mitogen-Activated Protein Kinase

(2013) Jing Wu et al.   CIRCULATION RESEARCH

Arterial Stiffening Precedes Systolic Hypertension in Diet-Induced Obesity

(2013) Robert M. Weisbrod et al.   HYPERTENSION

The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition

(2013) Xun Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma

(2013) B Mao et al.   ONCOGENE

The ways and means that fine tune Sirt1 activity

(2013) Javier R. Revollo et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein Tyrosine Nitration: Biochemical Mechanisms and Structural Basis of Functional Effects

(2012) Rafael Radi   ACCOUNTS OF CHEMICAL RESEARCH

Cathepsin Cleavage of Sirtuin 1 in Endothelial Progenitor Cells Mediates Stress-Induced Premature Senescence

(2012) Jun Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

Aortic Stiffness, Blood Pressure Progression, and Incident Hypertension

(2012) Bernhard M. Kaess et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Novel Acetylation Cycle of Transcription Co-activator Yes-associated Protein That Is Downstream of Hippo Pathway Is Triggered in Response toSN2 Alkylating Agents

(2012) Shoji Hata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice

(2011) Li Li et al.   CIRCULATION RESEARCH

Physiology and pathophysiology of matrix metalloproteases

(2010) T. Klein et al.   AMINO ACIDS

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

(2010) Samuel Caito et al.   FASEB JOURNAL

ACUTE EFFECTS OF NICOTINE ON ARTERIAL STIFFNESS AND WAVE REFLECTION IN HEALTHY YOUNG NON-SMOKERS

(2009) Dionysios Adamopoulos et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1

(2009) Lei Chen et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Interfering with Glycolysis Causes Sir2-Dependent Hyper-Recombination of Saccharomyces cerevisiae Plasmids

(2009) Markus Ralser et al.   PLoS One

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA