Article
Biochemistry & Molecular Biology
Marco Orecchioni, Dennis Wolf, Vasantika Suryawanshi, Holger Winkels, Kouji Kobiyama, Jeffrey Makings, William B. Kiosses, Klaus Ley
Summary: Atherosclerosis is caused by the retention of lipoproteins and cholesterol in the subendothelial layer, leading to an inflammatory process and plaque formation. Macrophages are found to be the main producers of the anti-inflammatory cytokine IL-10 in atherosclerotic plaques. IL-10 secretion by macrophages is critical for limiting atherosclerosis progression.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Huilun Wang, Yanhong Guo, Haocheng Lu, Yonghong Luo, Wenting Hu, Wenying Liang, Minerva T. Garcia-Barrio, Lin Chang, Anna Schwendeman, Jifeng Zhang, Y. Eugene Chen
Summary: Atherosclerosis is influenced by KLF14 expression in macrophages, which plays a role in promoting cholesterol efflux and suppressing inflammatory response. Activation of KLF14 by perhexiline can inhibit inflammation and increase cholesterol efflux in a KLF14-dependent manner without triggering hepatic lipogenesis, representing a potential new therapeutic approach for preventing or treating atherosclerosis.
CARDIOVASCULAR RESEARCH
(2022)
Article
Oncology
Adam N. R. Cartwright, Shengbao Suo, Soumya Badrinath, Sushil Kumar, Johannes Melms, Adrienne Luoma, Archis Bagati, Assieh Saadatpour, Benjamin Izar, Guo-Cheng Yuan, Kai W. Wucherpfennig
Summary: The study demonstrates that MDSCs do not block early steps of T-cell activation but induce DNA damage and p53 pathway activation in CD8(+) T cells through an iNOS-dependent pathway.
CANCER IMMUNOLOGY RESEARCH
(2021)
Review
Hematology
Abraham J. P. Teunissen, Mandy M. T. van Leent, Geoffrey Prevot, Eliane E. S. Brechbuhl, Carlos Perez-Medina, Raphael Duivenvoorden, Zahi A. Fayad, Willem J. M. Mulder
Summary: This article explores the role of trained immunity in atherosclerosis and the progress in utilizing nanobiologics for immune therapy targeting myeloid cells. The research demonstrates that nanobiologics have consistent biocompatibility and in vivo behavior across different species.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Laura A. Bosmans, Claudia M. van Tiel, Suzanne A. B. M. Aarts, Lisa Willemsen, Jeroen Baardman, Bram W. van Os, Myrthe den Toom, Linda Beckers, David J. Ahern, Johannes H. M. Levels, Aldo Jongejan, Perry D. Moerland, Sanne G. S. Verberk, Jan van den Bossche, Menno M. P. J. de Winther, Christian Weber, Dorothee Atzler, Claudia Monaco, Norbert Gerdes, Annelie Shami, Esther Lutgens
Summary: This study investigates the role of CD40 in atherosclerosis and shows that inhibiting CD40 signaling can reduce atherosclerosis. The researchers used myeloid-specific CD40-deficient mice and found that the absence of CD40 in myeloid cells reduces atherosclerosis and systemic inflammation by preventing pro-inflammatory macrophage polarization.
CARDIOVASCULAR RESEARCH
(2023)
Review
Immunology
Aleksandra M. Mazitova, Ana Cristina Marquez-Sanchez, Ekaterina K. Koltsova
Summary: Adipose tissue inflammation is connected to chronic inflammatory diseases and cancer. Perivascular adipose tissue plays a role in atherosclerosis development and stores various immune cells. Recent studies show that adipocytes can directly respond to inflammatory stimuli.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Wenzhen Zhu, Wenying Liang, Haocheng Lu, Lin Chang, Jifeng Zhang, Y. Eugene Chen, Yanhong Guo
Summary: Genetic variants in TM6SF2 are associated with atherosclerosis, and myeloid TM6SF2 deficiency inhibits atherosclerosis development and foam cell formation by reducing inflammation and ER stress.
Article
Cardiac & Cardiovascular Systems
Prakash Doddapattar, Rishabh Dev, Madankumar Ghatge, Rakesh B. Patel, Manish Jain, Nirav Dhanesha, Steven R. Lentz, Anil K. Chauhan
Summary: This study demonstrates that myeloid cell-specific PKM2 regulates macrophage efferocytosis and atherosclerosis. Deletion or inhibition of PKM2 reduces atherosclerotic lesions, suppresses inflammation, and enhances macrophage efferocytosis.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Kim van Kuijk, Jasper A. F. Demandt, Javier Perales-Paton, Thomas L. Theelen, Christoph Kuppe, Elke Marsch, Jenny de Bruijn, Han Jin, Marion J. Gijbels, Ljubica Matic, Barend M. E. Mees, Chris P. M. Reutelingsperger, Ulf Hedin, Erik A. L. Biessen, Peter Carmeliet, Andrew H. Baker, Rafael K. Kramann, Leon J. Schurgers, Julio Saez-Rodriguez, Judith C. Sluimer
Summary: Myeloid-specific PHD2cko and PHD3ko enhanced atherosclerotic plaque growth and macrophage apoptosis, while PHD2cko macrophages further activated fibroblast collagen secretion through paracrine SPP1 signaling via TREM2hi macrophages.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Liangwei Duan, Yucong Zhao, Jing Jia, Tianzhu Chao, Hao Wang, Yinming Liang, Yunwei Lou, Qianqian Zheng, Hui Wang
Summary: In atherosclerosis, macrophages play an important role in inflammation. CD68, a specific receptor in macrophages, regulates the occurrence and development of atherosclerosis. CD68 deficiency can reduce atherosclerosis, decrease inflammation and necrotic content, and increase smooth muscle cell content in atherosclerotic plaques.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Subhapradha Rangarajan, Davit Orujyan, Patrida Rangchaikul, Mohamed M. Radwan
Summary: Recent research on resolving inflammation in the body is providing new insights for the management of cardiovascular diseases. This narrative review discusses the pathophysiology of atherosclerosis, the discovery of specialized pro-resolving mediators (SPMs), and the potential impact on cardiovascular treatment options. Further research is expected to translate these findings into clinical trials for conditions with an inflammatory basis.
Review
Immunology
Elena Magrini, Luna Minute, Monica Dambra, Cecilia Garlanda
Summary: Inflammation related to cancer plays a key role in promoting tumor development, and the complement system is one of the inflammatory mechanisms activated in the tumor microenvironment. It can affect tumor growth by promoting immunosuppression and invasiveness.
SEMINARS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Bhupesh Singla, Hui-Ping Lin, WonMo Ahn, Jiean Xu, Qian Ma, Moses Sghayyer, Kunzhe Dong, Mary Cherian-Shaw, Jiliang Zhou, Yuqing Huo, Joseph White, Gabor Csanyi
Summary: This study demonstrates the potential of targeting SIRP alpha in atherosclerosis and highlights the importance of cell-specific CD47 inhibition as a future therapeutic strategy. Results show that loss of SIRP alpha signaling in macrophages can stimulate efferocytosis and attenuate arterial wall inflammation, while loss of myeloid cell CD47 can impair cholesterol efflux and promote cellular inflammation in atherosclerotic vessels. Comprehensive blood cell analysis also revealed differences in haemoglobin and erythrocyte levels between Cd47(-/-) mice compared to wild-type and Sirpa(mut/mut) mice.
CARDIOVASCULAR RESEARCH
(2022)
Article
Multidisciplinary Sciences
Thi Tran, Jean-Remi Lavillegrand, Cedric Lereverend, Bruno Esposito, Lucille Cartier, Melanie Montabord, Jaouen Tran-Rajau, Marc Diedisheim, Nadege Gruel, Khadija Ouguerram, Lea Paolini, Olivia Lenoir, Emmanuel Pinteaux, Eva Brabencova, Corinne Tanchot, Pauline Urquia, Jacqueline Lehmann-Che, Richard Le Naour, Yacine Merrouche, Christian Stockmann, Ziad Mallat, Alain Tedgui, Hafid Ait-Oufella, Eric Tartour, Stephane Potteaux
Summary: This study reveals the role of pro-atherogenic environment and low-grade inflammation in tumor progression. Feeding mice with a high fat high cholesterol diet increases certain type of monocytes that are available for melanoma development. These cells, which accumulate in the tumor microenvironment, enhance pro-angiogenic and immunosuppressive activities. Limiting their accumulation or targeting specific protein production can slow down tumor growth. These findings shed light on the communication between cardiovascular diseases and cancer.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Jia-Nan Cheng, Yi-Xiao Yuan, Bo Zhu, Qingzhu Jia
Summary: MDSCs play a crucial role in regulating immune responses, promoting tumor progression, and predicting therapeutic outcomes. Targeting MDSCs could potentially improve treatment efficacy in cancer therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Dermatology
Theodosios Bisdas, Nikolaos Patelis, Georgia Argyrakopoulou, Dimitrios Tsiachris, Aristotelis Kurtis, Panagiotis Gargalianos-Kakoliris, Christodoulos Stefanadis
Summary: The complexity of critical limb ischemia (CLI) requires a dedicated multidisciplinary team for treatment. This study aimed to assess the effectiveness of referring CLI patients scheduled for major amputation elsewhere to a dedicated CLI center. The analysis showed that patients in severe stages of CLI who received a second opinion from a dedicated multidisciplinary team had high limb salvage and survival rates after major amputation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Pharmacology & Pharmacy
Dimitris Tsiachris, Ioannis Doundoulakis, Panagiotis Tsioufis, Eirini Pagkalidou, Christos-Konstantinos Antoniou, Stefanos M. Zafeiropoulos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This systematic review compares the effectiveness and safety of class Ic agents for cardioversion of paroxysmal AF and finds that intravenous flecainide is the most effective option. Class Ic agents appear to be safe for pharmacologic cardioversion of AF regardless of the presence of SHD.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Wolfram C. Poller, Jeffrey Downey, Agnes A. Mooslechner, Nargis Khan, Long Li, Christopher T. Chan, Cameron S. McAlpine, Chunliang Xu, Florian Kahles, Shun He, Henrike Janssen, John E. Mindur, Sumnima Singh, Mate G. Kiss, Laura Alonso-Herranz, Yoshiko Iwamoto, Rainer H. Kohler, Lai Ping Wong, Kashish Chetal, Scott J. Russo, Ruslan I. Sadreyev, Ralph Weissleder, Matthias Nahrendorf, Paul S. Frenette, Maziar Divangahi, Filip K. Swirski
Summary: This study demonstrates that different brain regions rapidly adjust the distribution and function of leukocytes throughout the body during acute stress, thereby affecting the susceptibility to diseases.
Article
Multidisciplinary Sciences
Manfred Nairz, Sabina Sahanic, Alex Pizzini, Anna Boehm, Piotr Tymoszuk, Anna-Maria Mitterstiller, Laura von Raffay, Philipp Grubwieser, Rosa Bellmann-Weiler, Sabine Koppelstatter, Andrea Schroll, David Haschka, Martina Zimmermann, Silvia Blunder, Kristina Trattnig, Helene Naschberger, Werner Klotz, Igor Theurl, Verena Petzer, Clemens Gehrer, John E. Mindur, Anna Luger, Christoph Schwabl, Gerlig Widmann, Guenter Weiss, Judith Loeffler-Ragg, Ivan Tancevski, Thomas Sonnweber
Summary: The CovILD study systematically followed up COVID-19 patients and found that S-specific IgG levels are correlated with immune activation, pulmonary function, and CT abnormalities. An S-specific IgG-based recovery score accurately predicted delayed pulmonary recovery after COVID-19. Therefore, S-specific IgG levels can serve as a useful immunological surrogate marker.
SCIENTIFIC REPORTS
(2022)
Article
Economics
Jay Pil Choi, Christodoulos Stefanadis
Summary: This article examines tippy network markets that allow price discrimination and finds that under certain conditions, network competition may lead to a unique subgame-perfect equilibrium where the winner's identity is fully determined by its product features. The concept of the dominant value margin is introduced as a metric for the effectiveness of divide-and-conquer strategies. However, the outcome of a market where suppliers with larger dominant value margins can sell to all customers does not necessarily result in social efficiency.
INTERNATIONAL ECONOMIC REVIEW
(2022)
Article
Multidisciplinary Sciences
Seung-Hyun Jung, Byung-Hee Hwang, Sun Shin, Eun-Hye Park, Sin-Hee Park, Chan Woo Kim, Eunmin Kim, Eunho Choo, Ik Jun Choi, Filip K. Swirski, Kiyuk Chang, Yeun-Jun Chung
Summary: Heart failure is a common consequence of myocardial infarction. This study used spatial transcriptomics and single-cell RNA-sequencing to investigate the dynamics of immune cells after myocardial infarction in a mouse model. The researchers identified twelve major immune cell populations, with macrophages being the most abundant. They found that Trem2 expression in macrophages was upregulated during the late phase after myocardial infarction. Injection of soluble Trem2 led to significant improvements in functional and structural aspects of infarcted hearts.
NATURE COMMUNICATIONS
(2022)
Letter
Cardiac & Cardiovascular Systems
Christodoulos Stefanadis, Christina Chrysohoou, Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Gerasimos Siasos, Konstantinos Tsioufis, George Panagiotakopoulos, Theoklis Zaoutis, Demosthenes Panagiotakos
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Grigorios Chatzantonis, Christos-Konstantinos Antoniou, Haris Lalos, Gregory C. Bogdanis, Pantelis Nikolaou, Anastasios Spanos, Stefanos Karagiannis, Costas Tsiou, Ali Yilmaz, Christodoulos Stefanadis
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Christos-Konstantinos Antoniou, Eirini Pagkalidou, Stefanos Zafeiropoulos, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of a time to isolation (TTI)-based strategy of cryoballoon ablation (CBA) in the treatment of atrial fibrillation. The results suggest that an individualized CBA dosing strategy based on TTI and extended duration of CBA can reduce recurrence post-AF ablation and decrease procedure time and incidence of phrenic nerve palsy.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Immunology
Cameron S. McAlpine, Mate G. Kiss, Faris M. Zuraikat, David Cheek, Giulia Schiroli, Hajera Amatullah, Pacific Huynh, Mehreen Z. Bhatti, Lai-Ping Wong, Abi G. Yates, Wolfram C. Poller, John E. Mindur, Christopher T. Chan, Henrike Janssen, Jeffrey Downey, Sumnima Singh, Ruslan I. Sadreyev, Matthias Nahrendorf, Kate L. Jeffrey, David T. Scadden, Kamila Naxerova, Marie-Pierre St-Onge, Filip K. Swirski
Summary: Sleep interruption affects the epigenome of hematopoietic stem and progenitor cells, leading to increased proliferation and reduced clonal diversity. Sleep restriction alters the epigenome of hematopoietic cells and activates hematopoiesis. The study shows that sleep plays a role in preserving the hematopoietic system by regulating the epigenome and maintaining clonal diversity.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Sudhir K. Yadav, Naoko Ito, John E. Mindur, Hetal Kumar, Mysra Youssef, Shradha Suresh, Ratuja Kulkarni, Yaritza Rosario, Konstantin E. Balashov, Suhayl Dhib-Jalbut, Kouichi Ito
Summary: Multiple Sclerosis (MS) is associated with intestinal inflammation and gut dysbiosis. In this study, it was found that spontaneous experimental autoimmune encephalomyelitis (EAE) and colitis develop simultaneously in humanized transgenic mice. The colon of these mice showed infiltration of MBP-specific Th17 cells and recruitment of neutrophils. Furthermore, elevated levels of fecal Lipocalin-2 (Lcn-2), a biomarker of intestinal inflammation, were observed in MS patients along with reduced bacterial diversity and increased levels of other intestinal inflammation markers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Athanasios Kordalis, Dimitrios Konstantinou, Konstantinos Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study compared the clinical outcomes of a three-dimensional electroanatomical mapping (3D-EAM)-based strategy targeting slow pathway (SP) elimination with the conventional fluoroscopic approach in atrioventricular node reentrant tachycardia (AVNRT) ablation. The results showed that 3D-EAM improved procedural parameters, reduced fluoroscopy time and dose, and increased SP elimination frequency. Follow-up results demonstrated lower recurrence rates and redo procedure rates in the 3D-EAM-based group.
JOURNAL OF ARRHYTHMIA
(2022)
Article
Immunology
Henrike Janssen, Florian Kahles, Dan Liu, Jeffrey Downey, Laura L. Koekkoek, Vladimir Roudko, Darwin D'Souza, Cameron S. McAlpine, Lennard Halle, Wolfram C. Poller, Christopher T. Chan, Shun He, John E. Mindur, MateG. Kiss, Sumnima Singh, Atsushi Anzai, Yoshiko Iwamoto, Rainer H. Kohler, Kashish Chetal, Ruslan I. Sadreyev, Ralph Weissleder, Seunghee Kim-Schulze, Miriam Merad, Matthias Nahrendorf, Filip K. Swirski
Summary: Diet plays a profound role in physiological processes, with over-nutrition increasing disease risk while caloric restriction and fasting have beneficial effects. However, the underlying biology connecting diet and health is still unclear. In this study, fasting was found to induce a switch in leukocyte migration, prolonging monocyte lifespan and altering susceptibility to disease in mice. This effect was mediated by the release of corticosterone through the hypothalamic-pituitary-adrenal (HPA) axis, which enhanced the CXCR4 chemokine receptor. These findings highlight the importance of diet, particularly its temporal dynamics, in modulating monocyte lifespan and response to external stressors.
Review
Neurosciences
Kenny L. Chan, Wolfram C. Poller, Filip K. Swirski, Scott J. Russo
Summary: Stress is associated with psychiatric disorders and systemic inflammation. Recent studies have shown that stress alters haematopoiesis and leads to inflammation in peripheral tissues. This peripheral inflammation contributes to the development of psychiatric symptoms and co-morbidities.
NATURE REVIEWS NEUROSCIENCE
(2023)
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
