Article
Virology
Yubao Zhao, Kun Chen, Hui Yang, Feng Zhang, Lu Ding, Yan Liu, Le Zhang, Yuchen Zhang, Huiliang Wang, Yang Deng
Summary: HLA-DR genetic polymorphisms may predispose the host to immunoselection of HCC-related HBV mutations and affect the risk of HCC possibly through interacting with HBV mutations.
Review
Virology
Giacomo Emanuele Maria Rizzo, Giuseppe Cabibbo, Antonio Craxi
Summary: Hepatitis B virus (HBV) infection is associated with the risk of developing hepatocellular carcinoma (HCC), with or without liver cirrhosis, through various mechanisms. The molecular profile of HBV-HCC is constantly being studied, and it is the result of altered molecular pathways, changes in the microenvironment, and DNA damage. Proper management of HBV-related liver disease is crucial for prevention and treatment of HCC.
Article
Oncology
Meng Xue, Xiaona Lin, Qiu-Xiong Lin, Xiaoyong Pu, Jiumin Liu, Xing-Fang Li, Jun Hou, Xudong Liu, Ren Chen
Summary: This study found that HBV infection was associated with an increased risk of HCC compared to HEV infection, and that HEV infection may mitigate the promoting impact of HBV on HCC development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Shuxiang Wu, Shuangshuang Ye, Xiaohan Lin, Yan Chen, Yi Zhang, Zhentang Jing, Wei Liu, Wannan Chen, Xinjian Lin, Xu Lin
Summary: Chronic hepatitis B virus (HBV) infection is a major global health issue, with the small protein SHBs playing a significant role in the malignant progression of HBV-related hepatocellular carcinoma (HCC). SHBs expression in HCC is associated with more advanced clinical stage and worse prognosis in HCC patients.
Review
Pharmacology & Pharmacy
Haijun Wang, Jie Yang, Ke Zhang, Jia Liu, Yushan Li, Wei Su, Na Song
Summary: Hepatocellular carcinoma (HCC) is a primary liver cancer with increasing incidence and mortality rates globally. The FGF/FGFR signaling axis has been shown to play an important role in HCC development, and targeted therapies are currently being developed to inhibit this pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nicholas Noverati, Rukaiya Bashir-Hamidu, Dina Halegoua-DeMarzio, Hie-Won Hann
Summary: Hepatitis B virus is a significant cause of hepatocellular carcinoma globally. The complex mechanisms of this virus include interactions with the host's immune system. Factors such as stress can amplify these mechanisms. Chronic stress, harmful to health, can suppress or activate the host's defense system, leading to tumor initiation and progression in liver cancer. Chronic stress, often overlooked, should be recognized as a potential risk factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Mirjam B. Zeisel, Francesca Guerrieri, Massimo Levrero
Summary: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is largely caused by chronic hepatitis B virus (HBV) infection. While antiviral therapies can suppress viral replication, there is currently no cure for chronic HBV infection. HBV contributes to liver carcinogenesis through direct and indirect effects on host epigenetic alterations, modulating gene expression.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Shun Kaneko, Masayuki Kurosaki, Kento Inada, Sakura Kirino, Yuka Hayakawa, Koji Yamashita, Leona Osawa, Shuhei Sekiguchi, Mayu Higuchi, Kenta Takaura, Chiaki Maeyashiki, Nobuharu Tamaki, Yutaka Yasui, Jun Itakura, Yuka Takahashi, Kaoru Tsuchiya, Hiroyuki Nakanishi, Namiki Izumi
Summary: This study investigated the virological characteristics of HBcrAg in CHB patients and the factors associated with HCC risk in HBeAg-negative patients. Results showed that higher levels of HBcrAg in HBeAg-negative patients were associated with cirrhosis and higher HBV DNA levels, and were an independent predictive factor for HCC development in patients receiving NA therapy.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Tarek Mohamed Kamal Motawi, Nermin Abdel Hamid Sadik, Dina Sabry, Sally Atef Fahim, Nancy Nabil Shahin
Summary: This study found a significant association between the rs62139665 polymorphism in the EpCAM gene and HCC risk, as well as EpCAM gene and protein expression levels in the Egyptian population. Serum levels of EpCAM may be promising for HCC diagnosis and improving the diagnostic accuracy of alpha-fetoprotein.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hyun-seok Kim, Xian Yu, Jennifer Kramer, Aaron P. Thrift, Pete Richardson, Yao-Chun Hsu, Avegail Flores, Hashem B. El-Serag, Fasiha Kanwal
Summary: This study evaluated the performance of 10 HCC risk prediction models in patients with HBV, showing that most models performed well in predicting HCC risk and identified low-risk subsets for exclusion from HCC surveillance. Further research is needed to validate these findings.
JOURNAL OF HEPATOLOGY
(2022)
Review
Oncology
Xinhe Zhang, Lin Guan, Haoyu Tian, Zilu Zeng, Jiayu Chen, Die Huang, Ji Sun, Jiaqi Guo, Huipeng Cui, Yiling Li
Summary: HCC is a common cancer with increasing incidence caused by HBV and HCV infections, liver cirrhosis, and metabolic risk factors. Predictive factors can assess the risk of HCC, and prevention strategies include vaccination, antiviral treatment, and HCC management to reduce recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Pierre Khalfi, Rodolphe Suspene, Vincent Caval, Valerie Thiers, Guillaume Beauclair, Agnes Marchio, Claudine Bekondi, Marie Amougou Atsama, Serge-Magloire Camengo-Police, Dominique Noah Noah, Richard Njouom, Herve Blanc, Thomas Vallet, Marco Vignuzzi, Pascal Pineau, Jean-Pierre Vartanian
Summary: This study demonstrates that APOBEC3C(S188I) editing enzyme can enhance the editing activity against HBV. Given the polymorphism of this editing enzyme in African populations and its restriction effect on immunodeficiency viruses, this finding holds significant implications.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Zhiwei Liu, Chih-Jen Huang, Yu-Han Huang, Mei-Hung Pan, Mei-Hsuan Lee, Kelly J. Yu, Ruth M. Pfeiffer, Mathias Viard, Yuko Yuki, Xiaojiang Gao, Mary Carrington, Chien-Jen Chen, Allan Hildesheim, Hwai- Yang
Summary: The study found that an increase in the number of homozygous HLA class II loci is associated with an increased risk of chronic HBV infection and HBV-associated HCC. Specifically, HLA-DQB1 homozygosity is significantly associated with HCC risk.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Shuqin Gu, Xin Fu, Guofu Ye, Chengcong Chen, Xiaoyi Li, Shihong Zhong, Libo Tang, Haitao Chen, Deke Jiang, Jinlin Hou, Yongyin Li
Summary: Persistent exposure to antigens during chronic hepatitis B infection leads to exhausted immune responses, hindering viral control. L-carnitine was found to modulate immune cells in chronic HBV infection by altering transcriptional profiles and suppressing T cell proliferation and function while enhancing other immune responses. The study suggests that manipulation of L-carnitine levels may influence the prognosis of patients with HBV infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Peng Lin, Dong-Yue Wen, Jin-Shu Pang, Wei Liao, Yu-Ji Chen, Yun He, Hong Yang
Summary: This study developed an overall survival prediction model based on protein expression profiles in HBV-infected nontumor liver tissues, demonstrating the feasibility of using protein expression profiles in nontumor liver tissues for survival prediction.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Jin Roh, Choong-Kyun Noh
Article
Gastroenterology & Hepatology
Hyo Jung Cho, Young Hwan Ahn, Min Suh Sim, Jung Woo Eun, Soon Sun Kim, Bong Wan Kim, Jimi Huh, Jei Hee Lee, Jai Keun Kim, Buil Lee, Jae Youn Cheong, Bohyun Kim
Summary: The study identified high MRE-LS, low serum albumin, major hepatic resection, higher albumin-bilirubin score, and higher serum alpha-fetoprotein as independent risk factors for PHLF. A risk prediction model based on MRE-LS showed excellent performance in predicting PHLF, especially grade B and C PHLF.
Article
Gastroenterology & Hepatology
Gil Ho Lee, Eunyoung Lee, Bumhee Park, Jin Roh, Sun Gyo Lim, Sung Jae Shin, Kee Myung Lee, Choong-Kyun Noh
Summary: By comparing the clinical outcomes of ESD and surgery in patients with UD intramucosal EGC, it was found that the ESD group had a shorter hospital stay, but inferior RFS and local recurrence were observed.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Choong-Kyun Noh, Eunyoung Lee, Gil Ho Lee, Sun Gyo Lim, Bumhee Park, Sung Jae Shin, Jae Youn Cheong, Kee Myung Lee
Summary: This study evaluated the association between regular endoscopic screening and interval cancer detection in the Korean National Cancer Screening Program. The results showed that regular screening can reduce the risk of interval cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Ju A. Son, Hye Ri Ahn, Donglim You, Geum Ok Baek, Moon Gyong Yoon, Jung Hwan Yoon, Hyo Jung Cho, Soon Sun Kim, Suk Woo Nam, Jung Woo Eun, Jae Youn Cheong
Summary: Investigating molecular markers for predicting HCC recurrence revealed novel gene signatures, potentially serving as prognostic indicators for patients.
Article
Oncology
Hye Ri Ahn, Geum Ok Baek, Moon Gyeong Yoon, Ju A. Son, Jung Hwan Yoon, Jae Youn Cheong, Hyo Jung Cho, Ho Chul Kang, Jung Woo Eun, Soon Sun Kim
Summary: The study reveals the overexpression of WASF2 in hepatocellular carcinoma (HCC) and its correlation with patient prognosis. Inactivation of WASF2 has anti-tumorigenic effects on HCC cells, suggesting that it could be a potential therapeutic target for HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jung Woo Eun, Hye Ri Ahn, Geum Ok Baek, Moon Gyeong Yoon, Ju A. Son, Ji Hyang Weon, Jung Hwan Yoon, Hyung Seok Kim, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Bong-wan Kim, Hyo Jung Cho
Summary: Cancer-associated fibroblasts (CAFs) in hepatocellular carcinoma (HCC) have downregulated expression of hsa-miR-101-3p and hsa-miR-490-3p, which target TGFBR1. The downregulation of these miRs and high TGFBR1 expression are associated with poor prognosis in HCC patients. TGFBR1 expression is also correlated with infiltration of immunosuppressive immune cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hyung Seok Kim, Su In Lee, Yu Rim Choi, Jiyun Kim, Jung Woo Eun, Kyoung Seob Song, Jee-Yeong Jeong
Summary: Epithelial-to-mesenchymal transition (EMT) plays a critical role in lung cancer development by promoting invasiveness and metastasis. The expression levels of tight junction proteins, ZO-1 and ZO-2, were found to be lower in lung cancer tissues compared to normal lung tissues. Knockdown of ZO-1 and ZO-2 regulated cell migration and invasion and affected macrophage polarization. The GNAQ-ZO-1/2 axis may have a tumor-suppressive role in lung cancer development and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Choong-Kyun Noh, Woohyun Jung, Min Jae Yang, Wook Hwan Kim, Jae Chul Hwang
Summary: The gut microbiome of patients with gallstones differs from that of healthy controls, but the microbiome does not change significantly three months after cholecystectomy. Our data revealed specific taxa associated with postcholecystectomy diarrhea (PCD), highlighting the potential for symptom relief through restoration of the gut microbiome.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Immunology
Eunyoung Lee, Gil Ho Lee, Bumhee Park, Sung Soo Ahn, Choong-Kyun Noh
Summary: This study investigated the association between abnormal FIT results and the onset of inflammatory bowel disease (IBD). The results indicated that a positive FIT result was associated with a higher risk of IBD. These findings suggest that abnormal FIT results could be a preceding sign of incident IBD in the general population, and regular screening for early disease detection might be beneficial for individuals with positive FIT results and suspected IBD symptoms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Choong-Kyun Noh, Eunyoung Lee, Bumhee Park, Sun Gyo Lim, Sung Jae Shin, Kee Myung Lee, Gil Ho Lee
Summary: This study investigated the long-term effect of Helicobacter pylori eradication on the prevention of metachronous gastric neoplasm after endoscopic submucosal dissection (ESD) of gastric adenoma. The results showed that eradication of H. pylori did not increase the risk of metachronous gastric neoplasm after ESD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Jung Woo Eun, Jung Hwan Yoon, Hye Ri Ahn, Seokhwi Kim, Young Bae Kim, Su Bin Lim, Won Park, Tae Wook Kang, Geum Ok Baek, Moon Gyeong Yoon, Ju A. Son, Ji Hyang Weon, Soon Sun Kim, Hyo Jung Cho, Jae Youn Cheong
Summary: This study discovered that cancer-associated fibroblasts (CAFs) play a crucial role in inducing resistance to tyrosine kinase inhibitors (TKIs) in hepatocellular carcinoma (HCC). The CAF-derived SPP1 was identified as a candidate molecule driving TKI resistance, and inhibitors of SPP1 can reverse this resistance. Additionally, the plasma level of SPP1 before TKI treatment can serve as a potential biomarker for predicting treatment response in advanced HCC patients.
CANCER COMMUNICATIONS
(2023)
Article
Oncology
Hyung Seok Kim, Jung Hwan Yoon, Geum Ok Baek, Moon Gyeong Yoon, Ji Eun Han, Hyo Jung Cho, Soon Sun Kim, Jee-Yeong Jeong, Jae Youn Cheong, Jung Woo Eun
Summary: This study introduces a comprehensive approach to identify the potential blood marker ITGA6 for early HCC detection. The upregulation of ITGA6 in HCC is confirmed, and it is associated with prognosis. Further analysis reveals that ITGA6 is predominantly expressed in TECs and enriched in angiogenesis-related pathways. This study sheds light on the potential of ITGA6 as a blood-based marker for HCC early detection and its interaction with the tumor microenvironment.
Meeting Abstract
Oncology
H. R. Ahn, J. A. Son, J. H. Weon, G. O. Baek, M. G. Yoon, J. E. Han, S. S. Kim, J. Y. Cheong, M. Kwon, J. W. Eun, H. J. Cho
EUROPEAN JOURNAL OF CANCER
(2022)
Meeting Abstract
Oncology
H. R. Ahn, J. W. Eun, J. H. Yoon, J. A. Son, J. H. Weon, G. O. Baek, M. G. Yoon, J. E. Han, M. Kwon, S. S. Kim, J. Y. Cheong, H. J. Cho
EUROPEAN JOURNAL OF CANCER
(2022)
