Article
Oncology
Yan-Jun Xiang, Kang Wang, Yi-Tao Zheng, Hong-Ming Yu, Yu-Qiang Cheng, Wei-Jun Wang, Yun-Feng Shan, Shu-Qun Cheng
Summary: Microvascular invasion (MVI) significantly impacts the prognosis of patients with hepatocellular carcinoma (HCC) after R0 liver resection. Among the eight commonly used staging systems, the Hong Kong Liver Cancer (HKLC) staging system showed the highest accuracy in predicting the prognosis of MVI patients. Incorporating MVI into current HCC staging systems may be necessary based on the findings.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yuling Xiong, Peng Cao, Xiaohua Lei, Weiping Tang, Chengming Ding, Shuo Qi, Guodong Chen
Summary: This study compared the clinical prognosis of HCC patients with or without tumor microvascular invasion (MVI) after radical surgical treatment and found that MVI is an independent risk factor for a poor prognosis after surgery. A prediction model based on preoperative AFP, tumor diameter, and TNM stage showed good predictive efficacy and clinical practicability.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Jian Li, Xin Su, Xiao Xu, Changchun Zhao, Ang Liu, Liwen Yang, Baoling Song, Hao Song, Zihan Li, Xiangyong Hao
Summary: Hepatocellular carcinoma (HCC) is a common and deadly tumor globally. Microvascular invasion (MVI) is a major risk factor for recurrence and poor prognosis in HCC patients after surgical resection. Accurate preoperative prediction of MVI status is crucial for clinicians in choosing treatment options and improving overall survival. Various indicators in serology (including liquid biopsies) and imaging have been identified as effective predictors of MVI occurrence, and a multi-indicator model based on deep learning greatly improves prediction accuracy. Additionally, certain genes and proteins have been identified as risk factors tightly associated with MVI occurrence. This review evaluates predictors and risk factors, providing guidance for future research on more accurate predictive methods and the conversion of risk factors into reliable predictors.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xin Zheng, Yun-Jun Xu, Jingcheng Huang, Shengxian Cai, Wanwan Wang
Summary: The purpose of this study was to develop three-class classification models for predicting the grade of MVI of HCC by combining enhanced computed tomography radiomics features with clinical risk factors. The clinical imaging model and radiomics model developed in this study had a specific predictive value for HCC MVI grading, and the combined application of the two models had a high predictive efficacy.
Article
Oncology
Huanhuan Wang, Ye Lu, Runkun Liu, Liang Wang, Qingguang Liu, Shaoshan Han
Summary: The study identified various predictors for microvascular invasion (MVI) in hepatocellular carcinoma patients, including higher serum concentrations of AFP and VEGF-A, lower lymphocyte count, peritumoral enhancement, irregular tumor shape, and intratumoral artery. A non-invasive nomogram incorporating blood biomarkers and imaging risk factors exhibited excellent predictive performance and calibration in preoperatively predicting MVI.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Yijie Hao, Qingxia Yang, Qiye He, Huanjing Hu, Zongpeng Weng, Zhixi Su, Shuling Chen, Sui Peng, Ming Kuang, Zhihang Chen, Lixia Xu
Summary: In this study, we developed and established a preoperative predictive model for microvascular invasion (MVI) status in patients with hepatocellular carcinoma (HCC) based on DNA methylation markers. The model showed high accuracy and is important for surgical strategy determination in HCC patients.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yunfei Zhang, Jiejun Chen, Chun Yang, Yongming Dai, Mengsu Zeng
Summary: Habitat imaging based on DWI can accurately predict the microvascular invasion of hepatocellular carcinoma preoperatively. By characterizing cellular density, perfusion, and heterogeneity, different habitats within the tumor can be identified and quantified for predicting MVI with high accuracy.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Wenjun Yao, Shuo Yang, Yaqiong Ge, Wenlong Fan, Li Xiang, Yang Wan, Kangchen Gu, Yan Zhao, Rujing Zha, Junjie Bu
Summary: Triphasic CT can be used to predict microvascular invasion in patients with hepatocellular carcinoma (HCC), and the novel combined clinical predictive model performed the best in predicting MVI, which can guide personalized treatment of HCC.
FRONTIERS IN MEDICINE
(2022)
Review
Oncology
Yu Jiang, Kang Wang, Yu-Ran Wang, Yan-Jun Xiang, Zong-Han Liu, Jin-Kai Feng, Shu-Qun Cheng
Summary: Microvascular invasion is an important factor affecting tumor recurrence after liver resection and transplantation. An international consensus is urgently needed for its classification. Recent studies have shown that artificial intelligence plays a significant role in improving the clinical management of hepatocellular carcinoma, particularly in the preoperative and prognostic prediction of microvascular invasion.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Article
Oncology
Jin Wang, Zhi-Wen Ding, Kuang Chen, Yan-Zhe Liu, Nan Li, Ming-Gen Hu
Summary: The study identified 23 key genes related to MVI status, established a classification model with an accuracy of 0.814, and found that HOXD9 and HOXD10 were overexpressed in HCC patients with MVI. The research provides a genomics model for predicting MVI risk and suggests the need for further study on DEGs related to MVI.
Article
Oncology
Xiang-Pan Meng, Tian-Yu Tang, Zhi-Min Ding, Jitao Wang, Chun-Qiang Lu, Qian Yu, Cong Xia, Tao Zhang, Xueying Long, Wenbo Xiao, Yuan-Cheng Wang, Shenghong Ju
Summary: This study developed two prediction models for microvascular invasion (MVI) in hepatocellular carcinoma (HCC) using clinical factors and preoperative computed tomography images. The models were compared and it was found that the model incorporating radiomics provided a more accurate estimation of MVI. This has the potential to assist in choosing the appropriate surgical procedure for HCC patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Fang Wang, Qingqing Chen, Yinan Chen, Yajing Zhu, Yuanyuan Zhang, Dan Cao, Wei Zhou, Xiao Liang, Yunjun Yang, Lanfen Lin, Hongjie Hu
Summary: This study developed and validated a novel deep learning (DL) model for predicting microvascular invasion (MVI) in hepatocellular carcinoma (HCC) based on multi-parameter magnetic resonance imaging (MRI) and contrast-enhanced computed tomography (CT). The DLCT thorn MRI model showed superior performance in predicting MVI compared to single-modality models.
Article
Oncology
Yang Zhang, Zhenyu Shu, Qin Ye, Junfa Chen, Jianguo Zhong, Hongyang Jiang, Cuiyun Wu, Taihen Yu, Peipei Pang, Tianshi Ma, Chunmiao Lin
Summary: The study systematically evaluated and compared the predictive capability for MVI in HCC patients based on mp-MRI, finding that the combined model could effectively predict MVI and identify high-risk populations.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shengsen Chen, Chao Wang, Yuwei Gu, Rongwei Ruan, Jiangping Yu, Shi Wang
Summary: The nomograms developed in this study allow personalized predictions of MVI and its M2 classification, aiding in the selection of appropriate treatment plans.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongxin Zhang, Xiaofei Lv, Jiliang Qiu, Bin Zhang, Lu Zhang, Jin Fang, Minmin Li, Luyan Chen, Fei Wang, Shuyi Liu, Shuixing Zhang
Summary: This study developed end-to-end deep-learning models based on MRI images for preoperative prediction of MVI in HCC patients, showing potential non-invasive predictive value that needs to be enhanced with larger cohort for improved accuracy.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Editorial Material
Gastroenterology & Hepatology
Benedetto Ielpo, Gabriella Pittau, Oriana Ciacio, Michele Tedeschi, Daniel Pietrasz, Laia Torrent, Antonio Sa Cunha, Daniel Cherqui
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2022)
Article
Medicine, General & Internal
Elisabeth Hain, Alexandre Challine, Stylianos Tzedakis, Alexandru Mare, Alessandro Martinino, David Fuks, Mustapha Adham, Guillaume Piessen, Jean-Marc Regimbeau, Emmanuel Buc, Louise Barbier, Jean-Christophe Vaillant, Florence Jeune, Laurent Sulpice, Fabrice Muscari, Lilian Schwarz, Sophie Deguelte, Antonio Sa Cunha, Stephanie Truant, Bertrand Dousset, Alain Sauvanet, Sebastien Gaujoux
Summary: The study compares the effectiveness of somatostatin and octreotide in preventing postoperative PF in patients undergoing pancreaticoduodenectomy or distal pancreatectomy, with a focus on the occurrence of grade B or C PF within 90 days after surgery. In addition, the study also evaluates overall length of stay, readmission rate, cost-effectiveness, and postoperative quality of life.
FRONTIERS IN MEDICINE
(2021)
Article
Surgery
Alessandro D. Mazzotta, Alina Pascale, Luis Cano, Olivier Rosmorduc, Marc-Antoine Allard, Antonio Sa Cunha, Rene Adam, Daniel Cherqui, Eric Vibert, Nicolas Golse
Summary: This study evaluated the impact of the number of nodules on the prognosis of liver transplant candidates, finding that patients with >=5 nodules had lower survival rates, suggesting the exclusion of high-risk patients.
TRANSPLANT INTERNATIONAL
(2021)
Article
Surgery
Sophie Laroche, Charlotte Maulat, Yuki Kitano, Nicolas Golse, Daniel Azoulay, Antonio Sa Cunha, Eric Vibert, Rene Adam, Daniel Cherqui, Marc Antoine Allard
Summary: The study evaluated the different surgical strategies with regard to IVC in late liver retransplantation (ReLT). The results showed that preserving the IVC is associated with better postoperative renal function, and patients with previous 3-vein piggyback are more suitable for IVC preservation.
TRANSPLANT INTERNATIONAL
(2021)
Article
Oncology
Edouard Auclin, Lysiane Marthey, Raef Abdallah, Leo Mas, Eric Francois, Angelique Saint, Antonio Sa Cunha, Angelique Vienot, Thierry Lecomte, Vincent Hautefeuille, Christelle de la Fouchardiere, Matthieu Sarabi, Feryel Ksontini, Julien Forestier, Romain Coriat, Emmanuelle Fabiano, Florence Leroy, Nicolas Williet, Jean-Baptiste Bachet, David Tougeron, Julien Taieb
Summary: FOLFIRINOX shows promising efficacy with manageable toxicity in treating locally advanced or borderline resectable pancreatic adenocarcinoma. Surgical resection rates are low but significantly impact overall survival for patients.
BRITISH JOURNAL OF CANCER
(2021)
Article
Anesthesiology
Alexandre Joosten, Brigitte Ickx, Zakaria Mokthari, Luc Van Obbergh, Valerio Lucidi, Vincent Collange, Salima Naili, Philippe Ichai, Didier Samuel, Antonio Sa Cunha, Brenton Alexander, Matthieu Legrand, Fabio Silvio Taccone, Anatole Harrois, Jacques Duranteau, Jean-Louis Vincent, Joseph Rinehart, Philippe van der Linden
Summary: A study on patients who underwent intermediate-to high-risk abdominal surgery found that the development of mild AKI postoperatively increased the risk of long-term renal injury.
BMC ANESTHESIOLOGY
(2021)
Article
Surgery
Raffaele Brustia, Alexis Laurent, Claire Goumard, Serena Langella, Daniel Cherqui, Takayuki Kawai, Olivier Soubrane, Francois Cauchy, Olivier Farges, Benjamin Menahem, Christian Hobeika, Rami Rhaiem, Daniele Sommacale, Shinya Okumura, Stefan Hofmeyr, Alessandro Ferrero, Francois-Rene Pruvot, Jean-Marc Regimbeau, David Fuks, Eric Vibert, Olivier Scatton
Summary: This study compared the overall survival of patients with intrahepatic cholangiocarcinoma who underwent open or laparoscopic liver resection. The results showed that laparoscopic liver resection was associated with better overall survival compared to open liver resection. Severe postoperative complications and steatosis were identified as predictors of death, while transfusion and severe postoperative complications were predictors of recurrence.
Article
Surgery
Rafaela Capelli, Yuki Kitano, Marcelo Linhares, Doris Da Silva, Nicolas Golse, Vincent Karam, Antonio Sa Cunha, Eric Vibert, Daniel Azoulay, Daniel Cherqui, Rene Adam, Marc-Antoine Allard
Summary: This study investigated the impact of AST and GGT levels in deceased donor serum on liver transplantation outcomes. They found no significant association between donor AST levels and 90-day graft survival, but a moderate association between GGT levels and 90-day graft survival. The study also noted a significant interaction with a donor history of alcohol abuse, impacting the risk of graft loss.
TRANSPLANT INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Frederic Marques, Mohammed Ghallab, Eric Vibert, Emmanuel Boleslawski, Olivier Soubrane, Rene Adam, Olivier Farges, Jean-Yves Mabrut, Jean-Marc Regimbeau, Daniel Cherqui, Marc-Antoine Allard, Antonio Sa Cunha, Didier Samuel, Francois-Rene Pruvot, Nicolas Golse
Summary: This study found that preoperative AFP levels can guide the necessary resection margins for treating HCC with high AFP levels. For HCC with low AFP levels, the resection margins did not affect the time to recurrence or overall survival.
Article
Gastroenterology & Hepatology
Muthukumarassamy Rajakannu, Audrey Coilly, Daniel Cherqui, Antonio Sa Cunha, Denis Castaing, Rene Adam, Didier Samuel, Eric Vibert
Summary: The aim of this study was to develop a model to predict clinically significant portal hypertension. A HVPG10 score model was developed based on preoperative liver stiffness measurement, liver function test, and intraoperative HVPG. The score showed good predictive ability in both training and validation sets. This model is important for ruling out portal hypertension and has implications for patients with chronic liver disease.
Article
Oncology
Camille Julio, Stephane Benoist, Marc-Antoine Allard, Francis Navarro, Patrick Pessaux, Antonio Sa Cunha, Antoine Brouquet
Summary: The background outcome of patients with resectable metachronous colorectal liver metastases after adjuvant oxaliplatin-based chemotherapy for colorectal cancer is not well defined, and the value of preoperative chemotherapy is controversial.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Maria Conticchio, Chady Salloum, Marc Antoine Allard, Nicolas Golse, Gabriella Pittau, Oriana Ciacio, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Rene Adam, Daniel Azoulay
Summary: This study on the use of RS for LPV reconstruction following hepatectomy shows promising outcomes in achieving better reperfusion and reducing complications in patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Yuki Kitano, Daniel Pietrasz, Elena Fernandez-Sevilla, Nicolas Golse, Eric Vibert, Antonio Sa Cunha, Daniel Azoulay, Daniel Cherqui, Hideo Baba, Rene Adam, Marc-Antoine Allard
Summary: The study evaluated the prognostic value of subjective difficulty scale (DS) after liver transplantation and identified predictors of difficulty. The study found that DS was associated with severe morbidity and impaired graft and patient survival. Cases with higher DS were more likely to experience vascular complications.
TRANSPLANT INTERNATIONAL
(2022)
Review
Gastroenterology & Hepatology
Daniel Azoulay, Cyrille Feray, Chetana Lim, Chady Salloum, Maria Conticchio, Daniel Cherqui, Antonio Sa Cunha, Rene Adam, Eric Vibert, Didier Samuel, Marc Antoine Allard, Nicolas Golse
Summary: This study analyzed the use of small-for-size liver grafts in patients with chronic liver disease and identified opportunities for auxiliary liver transplantation to address the shortage of liver grafts. The study found that despite high postoperative morbidity, the long-term results of auxiliary liver transplantation in these patients were good. However, further research and standardization of surgical techniques are needed for better outcomes.
Article
Surgery
C. Hobeika, F. Cauchy, D. Fuks, L. Barbier, J. M. Fabre, E. Boleslawski, J. M. Regimbeau, O. Farges, F. R. Pruvot, P. Pessaux, E. Salame, O. Soubrane, E. Vibert, O. Scatton
Summary: The laparoscopic approach did not significantly improve the quality of care for resectable ICC patients compared to open surgery, with lower rates of lymph node dissection and adjusted textbook outcome in laparoscopic resection.
BRITISH JOURNAL OF SURGERY
(2021)
