Article
Chemistry, Multidisciplinary
Bohan Yin, Willis Kwun Hei Ho, Xinyue Xia, Cecilia Ka Wing Chan, Qin Zhang, Yip Ming Ng, Ching Ying Katherine Lam, James Chung Wai Cheung, Jianfang Wang, Mo Yang, Siu Hong Dexter Wong
Summary: A multifunctional theragnostic nanoplatform, consisting of mesoporous silica-coated gold nanostar with a cyclic Arg-Gly-Asp (RGD)-coated gold nanocluster shell, is reported. This nanoplatform exhibits enhanced SERS signals, improved NIR-induced photothermal conversion efficiency, high drug loading efficiency, and effective NIR-triggered drug release. It shows excellent performance in tumor targeting and achieves ultraeffective therapy in tumor cells and mouse models with NIR irradiation. This study offers a promising approach to effective noninvasive tumor treatment using SERS imaging and on-site triggered chemo-PTT.
Article
Polymer Science
Dashan Qi, Haowei Zhu, Yingjie Kong, Qingming Shen
Summary: This study combines targeted nanomedicine with injectable hydrogel for photothermal-chemotherapy combination therapy. By injecting the hydrogel precursor solution, the nanomedicine can target tumor cells and continue to release, thereby improving the accuracy and efficacy of the treatment.
Article
Chemistry, Physical
Jun Yang, Zhen Sun, Qingqing Dou, Shuhan Hui, Peng Zhang, Rui Liu, Di Wang, Shan Jiang
Summary: A multiplex NIR light-responsive hydrogel platform (SA/DOX@hydrogel) is created for controlled synergetic chemotherapy and photothermal cancer therapy. The platform incorporates Ag nanoparticles doped SnS2 nanoflowers (SA) for photothermal effect and doxorubicin (DOX) for chemotherapy. The heat generated by NIR irradiation induces the release of DOX, while SA converts NIR light into thermal energy. In vitro and in vivo studies demonstrate the high efficacy of the SA/DOX@hydrogel system in killing cancer cells and suppressing tumor growth, making it a promising approach for cancer treatment.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Engineering, Environmental
Lihong Zhang, Siyi Ren, Chaowen Chen, Dongfang Wang, Bin Liu, Dongqing Cai, Zhengyan Wu
Summary: A near infrared light-driven release imidacloprid with magnetic collectability property was successfully constructed, utilizing a combination of AG, CP, ZIF-8, IM, and Fe3O4. This technology showed excellent controlled-release property, efficient loading of IM molecules, and convenient collection of remaining NDRI from water.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Multidisciplinary Sciences
Yanlin Lv, Feng Li, Shuang Wang, Guihong Lu, Weier Bao, Yugang Wang, Zhiyuan Tian, Wei Wei, Guanghui Ma
Summary: The anticancer platelet-based biomimetic formulation developed in this study integrates photothermal nanoparticles and immunostimulator into platelets to target tumor cells effectively. By accumulating at tumor sites and releasing active components, this formulation induces a strong immune response against residual, metastatic, and recurrent tumors, showing exceptionally high therapeutic efficacy across various murine models.
Article
Chemistry, Multidisciplinary
M. Kim, J. Choi, S. Y. Kim
Summary: This study focuses on a near-infrared light-tunable hydrogel soft actuator system that can achieve fast and precise mechanical actuation under low-intensity NIR light. By designing a bilayer structure with gold nanorods as a photothermal agent, the hydrogel exhibits rapid bending deformation through photothermally induced phase transition. The NIR-responsive bending actuation of the hydrogel can be precisely controlled by various parameters, showing promising potential for human-robot interaction interface applications.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Philipp Neidinger, Joshua Davis, Dominik Voll, Esa A. Jaatinen, Sarah L. Walden, Andreas N. Unterreiner, Christopher Barner-Kowollik
Summary: This study introduces a gold nanorod-driven methodology to induce free radical polymerization in water using near infrared light. The process utilizes photothermal conversion and heat transfer to generate radicals, allowing control over the molecular weight and reaction conversion of the polymers. The results demonstrate the potential of this initiation mechanism for inducing polymerization in biological environments.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Chuangui Sheng, Fangzhi Yu, Youming Feng, Ming Gao, Wei Li, Lele Li, Jian Zhao
Summary: Metal-organic frameworks (MOFs) are used as a promising platform for protein delivery due to their high loading capacity and tunable functionality. However, the controlled release of proteins from MOFs-based nanocarriers is still a challenge. In this study, a MOFs-based protein delivery system that can precisely control protein release using near-infrared (NIR) light is reported. The system involves the encapsulation of proteins and upconversion nanoparticles (UCNPs) within MOFs and the use of NIR light to trigger the release of the proteins.
Article
Engineering, Environmental
Huixin Wang, Wenshen Wang, Chengpan Li, Ao Xu, Bensheng Qiu, Fenfen Li, Weiping Ding
Summary: This study presented a novel microneedle system loaded with the multipurpose small molecule Flav7 for high-efficiency light-activated drug release for chemotherapy and high-performance light-controlled thermotherapy of tumors, as well as remarkable NIR-II fluorescence imaging to guide chemo-thermal therapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Dina S. Salem, Salem F. Hegazy, Salah S. A. Obayya
Summary: This study utilized a ternary system consisting of optimally prepared chitosan nanoparticles (ChNPs) efficiently encapsulating 5-Fluorouracil (5-FU) and loaded by gold nanoparticles (AuNPs) for synergistic chemophotothermal therapy. The synthesized nanocomposites exhibited excellent biocompatibility, stability, and killing efficiency of tumor cells, with a strong absorbance in the visible region promoting rapid drug release under laser exposure. The synergistic effect of the combined chemo-photothermal therapy was demonstrated through cytotoxicity experiments towards hepatocellular carcinoma cells (HepG2), highlighting the high potential of the 5-FU-ChNPs@Au nanocomposites as a therapeutic platform.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Xuan Liang, Shan Qian, Zhizheng Lou, Renming Hu, Yuchen Hou, Peng R. Chen, Xinyuan Fan
Summary: The development of a biocompatible photocatalytic technology termed CAT-NIR enables the spatiotemporal manipulation of biological processes in living animals using external near infrared light (NIR). This system utilizes Os(II) terpyridine complex as an efficient NIR photocatalyst for deboronative hydroxylation reactions, resulting in the release of bioactive molecules. CAT-NIR also allows for the regulation of affibody binding to cell surface receptors through genetic code expansion and computer-aided screening, providing a selective cell tagging technology with external NIR light.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Pharmacology & Pharmacy
Qiang Gao, Jun Gao, Chengqiang Ding, Shangji Li, Linhong Deng, Yong Kong
Summary: The combination nanoplatform of graphene quantum dots and gold-silver nanoclusters shows significant efficacy in chemo-photothermal combination therapy for cancer cells, which can be modulated by adjusting pH and near-infrared irradiation for treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Analytical
Kuanzhi Qu, Jing Xu, Yuanfei Xue, Junli Guo, Zhida Gao, Yan-Yan Song, Ye Mei
Summary: An enantioselective desorption strategy based on homochiral Au/TiO2 nanotubes was developed using a photothermal effect, enabling the selective separation of chiral molecules. Molecular docking simulations confirmed the role of hydrogen bonding in the origin of enantioselective desorption, offering a green and alternative approach for chiral molecule separation.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yanggui Wu, Senbin Chen, Jintao Zhu
Summary: The article introduces the construction of supramolecular polymer micelles using H-bond technology, loaded with chemotherapeutic drugs and photothermal agents for synergistic chemo-/photothermal therapies. These nanomedicines have enhanced drug loading capacity, transport performance, and stimuli-responsive drug release.
Article
Materials Science, Multidisciplinary
Chang-Ching Weng, Tsu-An Yang, Yaw-Kuen Li
Summary: In this study, multi-functional nanoparticles with targeting, thermal, and pH-sensitive features were fabricated for controlled drug release. The nanoparticles exhibited high drug-loading content and showed potential for therapeutic applications through photothermal effects and targeted delivery to tumor cells.
MATERIALS & DESIGN
(2021)
Review
Biochemical Research Methods
Juan Guo, Xueting Pan, Chaohui Wang, Huiyu Liu
Summary: This review focuses on molecular imaging-guided sonodynamic therapy (SDT), discussing the mechanisms of SDT, major molecular imaging techniques, and design principles based on nanoparticles. Furthermore, it summarizes the applications of imaging-guided SDT in cancer treatment, bacterial infections, and vascular diseases.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xueting Pan, Nier Wu, Shengyuan Tian, Juan Guo, Chaohui Wang, Yun Sun, Zezhong Huang, Fangzhou Chen, Qingyuan Wu, Ying Jing, Zhe Yin, Baohua Zhao, Xiaolu Xiong, Huiyu Liu, Dongsheng Zhou
Summary: Clinical therapy of multidrug resistant (MDR) bacteria-induced deep-tissue infections like pneumonia is challenging. This study developed ZIF-8-derived carbon@TiO2 nanoparticles (ZTNs) as inhalable sonosensitizers for the treatment of bacterial pneumonia. The ZTNs showed excellent efficacy in killing Gram-negative MDR bacteria in vitro upon ultrasound irradiation. In animal models, the ZTNs effectively eliminated bacteria in the lungs and even achieved 100% survival rate in severely immunodeficient mice with lethal bacterial pneumonia, without obvious toxicity.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Shanshan Li, Bolong Xu, Mingzhu Lu, Mengxue Sun, Haokun Yang, Shuang Liu, Zhijun Huang, Huiyu Liu
Summary: Surface reconstruction and lattice tensile strain are utilized to activate the inactive facets of palladium nanosheets, leading to the development of strained palladium nanosheets with photodynamic, catalase-like, and peroxidase-like properties. These strained nanosheets exhibit higher tumor inhibition rate compared to the original palladium nanosheets.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Bolong Xu, Zhijun Huang, Yunhang Liu, Shanshan Li, Huiyu Liu
Summary: Nanomedicines with chemical activity have great potential as therapeutic agents in various biomedical fields. The idea of bioinspired design has provided guidance for designing and manufacturing nanomedicines with high chemical activity and desired therapeutic outcomes. This review focuses on nanomedicines inspired by structures of natural active components, with a particular emphasis on the recent development of metal-organic framework (MOF)-based bioinspired nanomedicines.
Article
Chemistry, Multidisciplinary
Shuang Liu, Tianshu Zhang, Shanshan Li, Qingyuan Wu, Kexin Wang, Xican Xu, MingZhu Lu, Rongguang Shao, Wuli Zhao, Huiyu Liu
Summary: This study reports a nanotherapeutic strategy based on MnOx-loaded polydopamine (MnOx/PDA) nanobombs with chemodynamic, photodynamic, photothermal, and biodegradation properties to simultaneously inhibit cancer stem cells (CSCs) and non-CSCs. The MnOx/PDA nanobombs can directly disrupt the microenvironment and tumorigenic capacity of CSCs by generating hyperthermia, oxidative stress, and alleviating hypoxia. Additionally, they can directly ablate the bulk tumor cells, cutting off the supply of CSCs transformation. The synergistic therapy achieved a tumor inhibition rate of 70.8% in a colorectal cancer (CRC) model.
Article
Chemistry, Multidisciplinary
Mengxue Sun, Meichen Yang, Shanshan Li, Chaohui Wang, Fengrong Zhang, Bolong Xu, Yulian Zhang, Xinxiao Sun, Qipeng Yuan, Huiyu Liu
Summary: A novel light-controlled engineered bacterial material is developed for synergistic regulation of amino acid metabolism to combat tumors. In vitro and in vivo experiments demonstrate that this method effectively inhibits tumor growth and induces apoptosis of tumor cells. This strategy provides new ideas for the combination of synthetic biology and nanotechnology in anti-tumor therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Mengya He, Xican Xu, Hongyu Wang, Qingyuan Wu, Linghao Zhang, Dongsheng Zhou, Yigang Tong, Xin Su, Huiyu Liu
Summary: A cut-price colorimetric method using iron manganese silicate nanozyme (IMSN) has been developed for detecting SARS-CoV-2 RNA. This method catalyzes the oxidation of chromogenic substrates by the peroxidase-like activity of IMSN, which is inhibited by pyrophosphate ions (PPi). With a detection limit of 240 copies mL(-1), SARS-CoV-2 RNA can be detected by a colorimetric readout visible to the naked eye. This low-cost and instrumental-free approach has been successfully applied to differentiate positive and negative oropharyngeal swab samples of COVID-19 patients.
Article
Chemistry, Multidisciplinary
Xuan Ouyang, Xican Xu, Qingqing Qin, Chenxi Dai, Hongyu Wang, Shuang Liu, Lingfei Hu, Xiaolu Xiong, Huiyu Liu, Dongsheng Zhou
Summary: Bacterial pneumonia is a leading cause of death worldwide. Current vaccines have limitations, so there is a need to develop next-generation vaccines. This study developed a novel nanoparticle vaccine that effectively prevents pneumonic plague.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Xueting Pan, Wenping Huang, Guangjun Nie, Changyong Wang, Hai Wang
Summary: This review provides an overview of ultrasound therapy for neurological diseases, focusing on the potential of ultrasound-sensitive intelligent nanosystems (USINs). Rational design of USINs is crucial for enhancing the efficacy of ultrasound therapy. The recent developments of ultrasound-sensitive nanocarriers and nanoagents are also summarized, and the challenges and prospects of USINs are discussed in depth.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shuncheng Yao, Qingyuan Wu, Shaobo Wang, Yunchao Zhao, Zhuo Wang, Quanhong Hu, Linlin Li, Huiyu Liu
Summary: A self-driven electrical stimulation system is constructed to enhance the cascade catalytic activity of alloy nanoparticles (ANs) for cancer therapy. When delivering the electric stimulation to AuPd ANs through a triboelectric nanogenerator, multiple catalytic activities are substantially improved, forming proper cascade reactions to boost the final production of free radicals and improve therapeutic outcomes.
Article
Chemistry, Multidisciplinary
Qingyuan Wu, Jie Zhang, Xueting Pan, Zhijun Huang, Haoyuan Zhang, Juan Guo, Yun Xue, Rui Shi, Huiyu Liu
Summary: Sonodynamic therapy (SDT) is a noninvasive and high-penetration therapy for cancer, but the design of an efficient sonosensitizer is still lacking. Researchers have designed molybdenum disulfide nanoflowers (MoS2 NF) as piezo-sonosensitizers and introduced sulfur vacancies on the MoS2 NF (Sv-MoS2 NF) to improve their piezoelectric property for cancer therapy. Under ultrasonic mechanical stress, the Sv-MoS2 NF exhibited enhanced piezoelectric polarization and band tilting, leading to improved charge carrier separation and migration, resulting in enhanced reactive oxygen species (ROS) production and ultimately improved SDT performance. The Sv-MoS2 NF demonstrated a promising anticancer effect in vitro and in vivo, and also showed good biocompatibility.
Article
Chemistry, Multidisciplinary
Shanshan Li, Bolong Xu, Haokun Yang, Chong Zhang, Jiali Chen, Shuang Liu, Zhijun Huang, Huiyu Liu
Summary: This paper reports a biodegradable Pt1Pd single-atom alloy nanozyme, which exhibits enzyme-like catalytic performance and photodynamic effect. The introduction of single-atom Pt sites is proven to enhance its catalytic efficiency towards substrates, resulting in photo-controlled therapeutic effects.
Review
Biochemistry & Molecular Biology
Bolong Xu, Shanshan Li, Rui Shi, Huiyu Liu
Summary: Mesoporous silica nanoparticles (MSNs) have great potential in the biomedical field, with their easily tunable structure and composition, diverse surface functionalization properties, and excellent biocompatibility. This review provides a comprehensive summary of the development history, nanostructured architectures, and surface functionalization of MSNs, as well as their biomedical applications and progress in clinical trials. The future direction and challenges of MSNs in the biomedical field are also discussed.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Chemistry, Physical
Xican Xu, Jin Zhang, Shuang Liu, Chaohui Wang, Hongyu Wang, Huahao Fan, Yigang Tong, Huiyu Liu, Dongsheng Zhou
Summary: This article summarizes the recent advances in nanomaterial-based antiviral strategies, including antiviral nanodrugs, drug nanocarriers, and nanovaccines, and discusses the clinical challenges and prospects of these strategies.
