期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 19, 页码 6396-6399出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201900693
关键词
(3+2) cycloaddition; aminoallyl; dienes; palladium; pyrrolidines
We describe the design and application of tailored aminoallyl precursors for catalytic (3+2) cycloaddition with conjugated dienes via a Pd-aminoallyl intermediate. The new cycloaddition reactions override the conventional (4+3) selectivity of aminoallyl cation cycloaddition through a sequence of Pd-allyl transfer and ring closure. A variety of highly substituted or fused pyrrolidine rings were synthesized using the cycloaddition, and can further undergo [1,3] N-to-C rearrangement to five-membered carbocycles with a different palladium catalyst. The utility of the (3+2) cycloaddition is also demonstrated by the preparation of various derivatives from the bicyclic pyrrolidine products.
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