期刊
ANALYTICAL CHEMISTRY
卷 91, 期 9, 页码 6340-6344出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.9b01324
关键词
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资金
- National Natural Science Foundation of China [81801768, 21703062, 81871440]
- Sichuan Science and Technology Department [2019YJ0385]
- Scientific Research Project of Sichuan Provincial Department of Education [18ZA0200]
- Bureau of Science & Technology and Intellectual Property Nanchong City [16YFZJ0121, 18SXHZ0491]
- North Sichuan Medical College [CBY16-QD01]
Detection of cancer in its early stages is difficult, and this is a major issue that impairs the timely diagnosis and treatment of tumors. Integrin alpha(nu)beta(3) is expressed on tumoral endothelial cells, as well as other tumor cells. By functionalizing the triarylboron (TAB) compound with multiple cyclic arginine-glycine-aspartic acid (cRGD) motifs, which specifically bind to integrin alpha(nu)beta(3), a multivalent two-photon fluorescent probe TAB-3-cRGD was designed and chemically synthesized. Through cell imaging experiments, we showed that TAB-3-cRGD can selectively bind to integrin alpha(nu)beta(3) on the cell surface and can effectively distinguish normal cells from tumor cells overexpressing integrin alpha(nu)beta(3). Using a mouse model, we also showed that TAB-3-cRGD could target the tumor site in vivo, offering a promising tool for cancer detection.
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