The role of polyamines in the regulation of macrophage polarization and function

Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses

(2018) Kshipra Singh et al.   CANCER RESEARCH

Spermine Alleviates Acute Liver Injury by Inhibiting Liver-Resident Macrophage Pro-Inflammatory Response Through ATG5-Dependent Autophagy

(2018) Shun Zhou et al.   Frontiers in Immunology

ODC1 inhibits the inflammatory response and ROS-induced apoptosis in macrophages

(2018) Fang Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis

(2018) Lori A. Coburn et al.   ONCOGENE

Tumor-associated macrophages: from basic research to clinical application

(2017) Li Yang et al.   Journal of Hematology & Oncology

EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis

(2017) D M Hardbower et al.   ONCOGENE

Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications

(2017) Dana M. Hardbower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel polyamine blockade therapy activates an anti-tumor immune response

(2017) Eric T. Alexander et al.   Oncotarget

l-Arginine Uptake by Cationic Amino Acid Transporter Promotes Intra-Macrophage Survival of Leishmania donovani by Enhancing Arginase-Mediated Polyamine Synthesis

(2017) Abhishek Mandal et al.   Frontiers in Immunology

Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection

(2016) Dana M. Hardbower et al.   AMINO ACIDS

Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM

(2016) Hongming Miao et al.   Nature Communications

A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma

(2015) Giselle L. Saulnier Sholler et al.   PLoS One

Activation of EGFR and ERBB2 by Helicobacter pylori Results in Survival of Gastric Epithelial Cells With DNA Damage

(2014) Rupesh Chaturvedi et al.   GASTROENTEROLOGY

Pharmacological and dietary agents for colorectal cancer chemoprevention: Effects on polyamine metabolism (Review)

(2014) MICHELE LINSALATA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Macrophage Polarization in Bacterial Infections

(2014) M. Benoit et al.   JOURNAL OF IMMUNOLOGY

Transcriptional enhancers: from properties to genome-wide predictions

(2014) Daria Shlyueva et al.   NATURE REVIEWS GENETICS

Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase

(2014) R Chaturvedi et al.   ONCOGENE

Chromatin remodeling by polyamines and polyamine analogs

(2013) Alice Pasini et al.   AMINO ACIDS

Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: enhancement of antimicrobial nitric oxide generation by depletion of spermine

(2013) Rupesh Chaturvedi et al.   AMINO ACIDS

Changes in macrophage phenotype as the immune response evolves

(2013) Julia Lichtnekert et al.   CURRENT OPINION IN PHARMACOLOGY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Increased Polyamines Alter Chromatin and Stabilize Autoantigens in Autoimmune Diseases

(2013) Wesley H. Brooks   Frontiers in Immunology

Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair

(2012) Maciej Lech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes

(2012) Jan Van den Bossche et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulatory macrophages: Setting the Threshold for Therapy

(2011) Bryan D. Fleming et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Spermine Oxidase Mediates the Gastric Cancer Risk Associated With Helicobacter pylori CagA

(2011) Rupesh Chaturvedi et al.   GASTROENTEROLOGY

Immune Evasion by Helicobacter pylori Is Mediated by Induction of Macrophage Arginase II

(2011) N. D. Lewis et al.   JOURNAL OF IMMUNOLOGY

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

(2011) Stephen J Galli et al.   NATURE IMMUNOLOGY

Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk

(2010) L. E. Wroblewski et al.   CLINICAL MICROBIOLOGY REVIEWS

Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production

(2010) Rupesh Chaturvedi et al.   GASTROENTEROLOGY

Helicobacter pyloriInduces ERK-dependent Formation of a Phospho-c-Fos·c-Jun Activator Protein-1 Complex That Causes Apoptosis in Macrophages

(2010) Mohammad Asim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arginase II Restricts Host Defense to Helicobacter pylori by Attenuating Inducible Nitric Oxide Synthase Translation in Macrophages

(2010) Nuruddeen D. Lewis et al.   JOURNAL OF IMMUNOLOGY

Role of Innate Immunity in Helicobacter pylori-Induced Gastric Malignancy

(2010) Richard M. Peek et al.   PHYSIOLOGICAL REVIEWS

Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes

(2009) J. Van den Bossche et al.   BLOOD

Polyamine analogues targeting epigenetic gene regulation

(2009) Yi Huang et al.   Essays in Biochemistry

Mammalian polyamine metabolism and function

(2009) Anthony E. Pegg   IUBMB LIFE

PneumocystisMediates Overexpression of Antizyme Inhibitor Resulting in Increased Polyamine Levels and Apoptosis in Alveolar Macrophages

(2009) Chung-Ping Liao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophages Are Mediators of Gastritis in Acute Helicobacter pylori Infection in C57BL/6 Mice

(2008) M. Kaparakis et al.   INFECTION AND IMMUNITY

Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

(2008) Karim C El Kasmi et al.   NATURE IMMUNOLOGY