Article
Dermatology
Maryanne Senna, Justin Ko, Marc Glashofer, Chloe Walker, Susan Ball, Emily Edson-Heredia, Baojin Zhu, Jerry Shapiro
Summary: Although the severity of alopecia areata (AA) is often determined by the extent of scalp hair loss, its impact on quality of life (QOL) can also be a defining factor. This study found that patients' perception of disease severity, as well as eyelash and eyebrow involvement, were significant predictors of diminished QOL.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Green & Sustainable Science & Technology
Robert Szydlo, Sylwia Wisniewska, Malgorzata Cwiek
Summary: This study aims to address the gap in research tools for studying the quality of life of young adults by creating an inventory for multidimensional research on students' quality of life, demonstrating its structural and theoretical validity, and reliability. The findings show that the Multidimensional Inventory of Students Quality of Life (MIS-QOL) has good structural validity and reliability, with correlations to commonly used questionnaires and the ability to compare data with international research.
Article
Computer Science, Information Systems
Satoshi Nakagawa, Huang Minlie, Yasuo Kuniyoshi
Summary: This study focuses on estimating QOL scores accurately through a text-based method and successfully creates a QOL-specific dictionary, SqolDic, based on large-scale Japanese textual data. Experimental results demonstrate the effectiveness of our system in estimating conversation content and QOL scores as well as the proposed QOL dictionary.
Article
Dermatology
Toni Maria Janke, Vlastimil Kozon, Skaidra Valiukeviciene, Laura Rackauskaite, Adam Reich, Katarzyna Stepien, Pavel Chernyshov, Monika Jankechova, Catherine van Montfrans, Stella Amesz, Marjam Barysch, Elena Conde Montero, Matthias Augustin, Christine Blome
Summary: This study validates the Wound-QoL-17 and Wound-QoL-14 versions for assessing health-related quality of life in patients with chronic wounds. Both versions demonstrated high internal consistency and moderate to good test-retest reliability. They showed significant correlations with global HRQoL rating, DLQI total score, and clinical data such as odor and wound size. The availability of multiple language versions makes these questionnaires suitable for international studies and clinical practice.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Respiratory System
Gail M. Gauvreau, Jens M. Hohlfeld, J. Mark FitzGerald, Louis-Philippe Boulet, Donald W. Cockcroft, Beth E. Davis, Stephanie Korn, Oliver Kornmann, Richard Leigh, Irvin Mayers, Henrik Watz, Sarah S. Grant, Monish Jain, Maciej Cabanski, Peter E. Pertel, Ieuan Jones, Jean R. Lecot, Hui Cao, Paul M. O'Byrne
Summary: The study evaluated the efficacy and safety of ecleralimab, an inhaled neutralizing antibody fragment against TSLP, in subjects with mild atopic asthma. The results showed that ecleralimab significantly reduced allergen-induced bronchoconstriction and airway inflammation, and it was safe in subjects with mild atopic asthma.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Dermatology
Jin Liu, Huijuan Li, Peiying Zhang, Rui Bai, Xiaojin Fu, Hui Guan, Bing Wen, Yanming Ding, Xin Qi
Summary: We aimed to translate and validate the Wound-QoL-17 questionnaire for measuring the quality of life in Chinese patients with chronic wounds. Through various tests and analyses, we found that the Chinese version of Wound-QoL-17 showed good reliability and validity, and is suitable for evaluating the quality of life of patients with chronic wounds.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Immunology
Katarzyna Wojcik-Pszczola, Krzysztof Pociecha, Grazyna Chlon-Rzepa, Monika Zadrozna, Barbara Nowak, Hanna Plutecka, Paulina Koczurkiewicz-Adamczyk, Katarzyna Przejczowska-Pomierny, Elzbieta Pekala, Reinoud Gosens, Elzbieta Wyska
Summary: This study investigated the effects of two pan-phosphodiesterase (PDE) inhibitors on a murine model of allergic asthma. The results showed that these inhibitors reduced airway inflammation and remodeling, and alleviated the symptoms of asthma by inhibiting the TGF-β/Smad signaling pathway. Therefore, these inhibitors may serve as potential anti-asthmatic drug candidates.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Health Care Sciences & Services
Nikki Ow, Adriana Appau, Mohamad Matout, Nancy E. Mayo
Summary: The review aims to develop a new framework and definition of pediatric QOL for children with disabilities, based on multiple qualitative studies involving children and adolescents with physical disabilities. Results showed that causal indicators, mitigators, and components of pediatric QOL include thoughts and feelings, fitting in, self-image, about the future, and independence.
QUALITY OF LIFE RESEARCH
(2021)
Article
Green & Sustainable Science & Technology
Yeong Gug Kim, Yeasun Kate Chung, Eunju Woo
Summary: This study aims to understand and examine the perception of platform workers regarding working conditions, work/life balance, and quality of life. It utilizes a conceptual model based on quality of life and work/life balance, and collects data through an online survey of 447 gig workers. The results indicate significant relationships between working environment, leisure domain, economic domain, emotional domain, overall quality of life, and psychological well-being, suggesting that factors in the life domain have more impact on overall quality of life than those in the work category. Implications for future research and the work environment for gig workers in the platform market are discussed.
Article
Gastroenterology & Hepatology
Seong Yong Park, Inkyung Jung, Seok Jae Heo, Go Eun Byun, Eun Young Lee, Dae Joon Kim
Summary: This study compared the quality of life of esophageal cancer patients who underwent reconstruction via the substernal or posterior mediastinal routes, and found no significant differences in symptom scales at 2 years postoperatively. Both reconstruction routes showed comparable quality of life outcomes.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Respiratory System
Maria Weitoft, Mans Kadefors, Henning Stenberg, Ellen Tufvesson, Zuzana Diamant, Sara Rolandsson Enes, Leif Bjermer, Oskar Rosmark, Gunilla Westergren-Thorsson
Summary: This study aimed to investigate the changes in plasma proteome and circulating hematopoietic progenitor cells associated with the late phase response (LPR) to inhaled allergens in asthmatic individuals. The results showed that LPR was associated with significant changes in a large proportion of plasma proteome, especially in protease inhibitors, which may influence the inflammatory response. Additionally, alterations in multiple coagulation-related proteins were found to be associated with LPR.
RESPIRATORY RESEARCH
(2022)
Article
Immunology
Timothy C. Borbet, Miranda B. Pawline, Xiaozhou Zhang, Matthew F. Wipperman, Sebastian Reuter, Timothy Maher, Jackie Li, Tadasu Iizumi, Zhan Gao, Megan Daniele, Christian Taube, Sergei B. Koralov, Anne Mueller, Martin J. Blaser
Summary: Antibiotics, commonly used in children, can alter gut microbiome communities and metabolic functions, which in turn affects host immunity. This study shows that early-life microbiome alterations due to antibiotic exposure can lead to increased susceptibility to allergy and asthma.
MUCOSAL IMMUNOLOGY
(2022)
Article
Psychiatry
Saleha Shafie, Ellaisha Samari, Anitha Jeyagurunathan, Edimansyah Abdin, Sherilyn Chang, Siow Ann Chong, Mythily Subramaniam
Summary: The study found no significant differences in QoL domain scores between male and female patients with schizophrenia, but revealed variations in different ethnicities, educational backgrounds, and marital statuses. This highlights the importance of considering these sociodemographic characteristics in treatments targeting QoL for patients with mental illnesses.
Article
Allergy
Simon Couillard, Nayia Petousi, Kate S. Smigiel, Nestor A. Molfino
Summary: Asthma and chronic obstructive pulmonary disease are currently diagnosed and treated after the demonstration of variable airflow limitation and symptoms. However, undiagnosed and unchecked airway inflammation can lead to various complications. Therefore, a paradigm shift towards a predict and prevent model is proposed, where inflammation is measured early and anti-inflammatory therapy is provided to prevent further deterioration.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Psychiatry
Ryunosuke Goto, Natsumi Matsuda, Maiko Nonaka, Yu Hamamoto, Yosuke Eriguchi, Mayu Fujiwara, Akane Suzuki, Yukari Yokoyama, Yukiko Kano
Summary: This study provides evidence on the validity and reliability of the GTS-QOL scale in Japanese patients with GTS, making it an effective tool for measuring disease-specific HR-QOL in this population.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Medical Laboratory Technology
Luciana Fontes de Oliveira, Celia Mallafre-Muro, Jordi Giner, Lidia Perea, Oriol Sibila, Antonio Pardo, Santiago Marco
Summary: This study demonstrates that breath sample analysis can effectively differentiate between control, bronchiectasis, and bronchiectasis with Pseudomonas Aeruginosa infection samples.
CLINICA CHIMICA ACTA
(2022)
Letter
Respiratory System
Alvar Agusti, Gaston De Stefano, Alberto Levi, Xavier Munoz, Christian Romero-Mesones, Oriol Sibila, Alejandra Lopez-Giraldo, Vicente Plaza Moral, Elena Curto, Andres L. Echazarreta, Silvana E. Marquez, Sergi Pascual-Guardia, Salud Santos, Alicia Marin, Luis Valdes, Fernando Saldarini, Clara Salgado, Georgina Casanovas, Sara Varea, Jose Rios, Rosa Faner
EUROPEAN RESPIRATORY JOURNAL
(2022)
Letter
Respiratory System
Jacobo Sellares, Carlos Guerrero, Daniel Martinez, Mariana Benegas, Sandra Cuerpo, Fernanda Hernandez-Gonzalez, Alejandra Libreros, Rudith Guzman, Angela Guirao, Marc Boada, David Sanchez-Lorente, Nuria Albacar, Leandro Grando, Pablo Paglialunga, Francisco Javier Garcia, Rosa Faner, Alvar Agusti, Oriol Sibila, Marcelo Sanchez, Laureano Molins, Jose Ramirez
ARCHIVOS DE BRONCONEUMOLOGIA
(2022)
Article
Respiratory System
Raja Dhar, Sheetu Singh, Deepak Talwar, B. V. Murali Mohan, Surya Kant Tripathi, Rajesh Swarnakar, Sonali Trivedi, Srinivas Rajagopala, George D'Souza, Arjun Padmanabhan, B. Archana, P. A. Mahesh, Babaji Ghewade, Girija Nair, Aditya Jindal, Gayathri Devi H. Jayadevappa, Honney Sawhney, Kripesh Ranjan Sarmah, Kaushik Saha, Suresh Anantharaj, Arjun Khanna, Samir Gami, Arti Shah, Arpan Shah, Naveen Dutt, Himanshu Garg, Sunil Vyas, Kummannoor Venugopal, Rajendra Prasad, Naveed M. Aleemuddin, Saurabh Karmakar, Virendra Singh, S. K. Jindal, Shubham Sharma, Deepak Prajapat, Sagar Chandrashekar, Michael Loebinger, Aditi Mishra, Francesco Blasi, Ramanathan Palaniappan Ramanathan, Pieter C. Goeminne, Preethi Vasudev, Amelia Shoemark, B. S. Jayaraj, Rahul Kungwani, Akanksha Das, Mehneet Sawhney, Eva Polverino, Tobias Welte, Nayan Sri Gulecha, Michal Shteinberg, Anshul Mangala, Palak Shah, Nishant Kumar Chauhan, Nikita Jajodia, Ashutosh Singhal, Sakshi Batra, Ashfaq Hasan, Stefano Aliberti, Megan L. Crichton, Sneha Limaye, Sundeep Salvi, James D. Chalmers
Summary: This study investigated the risk factors for poor outcome in a large population of bronchiectasis patients enrolled in India. The study found that frequent exacerbations at baseline were associated with an increased risk of mortality, severe exacerbations, future exacerbations, and lung function decline. Coexisting COPD, dyspnoea, and current cigarette smoking were similarly associated with a worse outcome.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Editorial Material
Respiratory System
Charlotte O. Pioch, David W. Connell, Amelia Shoemark
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Article
Immunology
Blanca Molins, Marc Figueras-Roca, Oliver Valero, Victor Llorenc, Sara Romero-Vazquez, Oriol Sibila, Alfredo Adan, Carolina Garcia-Vidal, Alex Soriano
Summary: In COVID-19 patients, monomeric CRP levels are associated with disease severity, and levels higher than 4000 ng/mL independently predict disease severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Critical Care Medicine
Lidia Perea, Rosa Faner, Belen Solarat, Amelia Shoemark, Stefano Aliberti, James D. Chalmers, Oriol Sibila
Review
Biology
Rodrigo Torres-Castro, Rodrigo Nunez-Cortes, Santiago Larrateguy, Xavier Alsina-Restoy, Joan Albert Barbera, Elena Gimeno-Santos, Agustin Roberto Garcia, Oriol Sibila, Isabel Blanco
Summary: COVID-19 survivors often experience various sequelae, including physical impairment, which can impact their quality of life and ability to return to work. Assessing physical capacity through field or laboratory tests has proven useful for evaluating post-COVID-19 patients and those with other chronic respiratory, metabolic, cardiac, or neurological diseases. When traditional tests are not feasible, assessing physical function can serve as a good alternative, particularly for evaluating intervention effects. Choosing the appropriate test should be based on the individual characteristics of each subject.
Editorial Material
Critical Care Medicine
James D. Chalmers, Amelia Shoemark
Editorial Material
Respiratory System
James D. Chalmers, Stefano Aliberti, Josje Altenburg, Francesco Blasi, Clare Clarke, Sanjay H. Chotirmall, Megan L. Crichton, Raja Dhar, Pieter Goeminne, Charles Haworth, Michael R. Loebinger, Natalie Lorent, Eva Polverino, Felix C. Ringshausen, Amelia Shoemark, Michal Shteinberg, Oriol Sibila, Arietta Spinou, Tobias Welte
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Biotechnology & Applied Microbiology
Nicholas W. Keiser, Erin Cant, Sneha Sitaraman, Amelia Shoemark, Maria P. Limberis
Summary: Primary ciliary dyskinesia (PCD) is a genetic disease characterized by defects in motile cilia, particularly in the lungs. Diagnosis of PCD is complex and often overlaps with other respiratory diseases. PCD is more common than previously thought and currently has no cure, but gene therapy is a promising treatment strategy.
HUMAN GENE THERAPY
(2023)
Article
Respiratory System
Tom Wilkinson, Anthony De Soyza, Miles Carroll, James D. Chalmers, Michael G. Crooks, Gareth Griffiths, Manu Shankar-Hari, Ling-Pei Ho, Alex Horsley, Chris Kell, Beatriz Lara, Biswa Mishra, Rachel Moate, Clive Page, Hitesh Pandya, Jason Raw, Fred Reid, Dinesh Saralaya, Ian C. Scott, Salman Siddiqui, Andy Ustianowski, Natalie van Zuydam, Ashley Woodcock, Dave Singh
Summary: This study investigated the efficacy and safety of the anti-IL-33 monoclonal antibody tozorakimab in COVID-19 patients. The results suggest that tozorakimab could be a novel therapy for hospitalized COVID-19 patients.
Meeting Abstract
Critical Care Medicine
J. Pollock, H. R. Keir, A. Shoemark, A. J. Dicker, Y. Giam, M. L. Crichton, E. Cant, J. T. J. Huang, J. D. Chalmers
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
M. B. Long, H. R. Keir, Y. Giam, H. Abo-Leyah, T. Pembridge, L. Delgado, R. Hull, A. Gilmour, C. Hughes, B. J. M. New, R. Dowey, H. Turton, D. Connell, D. Cassidy, H. Richardson, R. Thompson, A. M. Condliffe, A. Shoemark, J. D. Chalmers
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)