Article
Endocrinology & Metabolism
Qing Zhou, Yuyan Wang, Zongshi Lu, Bowen Wang, Li Li, Mei You, Lijuan Wang, Tingbing Cao, Yu Zhao, Qiang Li, Aidi Mou, Wentao Shu, Hongbo He, Zhigang Zhao, Daoyan Liu, Zhiming Zhu, Peng Gao, Zhencheng Yan
Summary: SIRT3 is involved in regulating metabolic reprogramming in proinflammatory macrophage polarization and plays an important preventive role in obesity.
Article
Biochemistry & Molecular Biology
Pavla Stankova, Otto Kucera, Eva Peterova, Moustafa Elkalaf, David Rychtrmoc, Jan Melek, Miroslav Podhola, Veronika Zubanova, Zuzana Cervinkova
Summary: The study found that after consuming a Western-style diet for 30 weeks, mice showed reduced succinate-activated respiration, decreased SDH activity, reduced expression of the SDH activator sirtuin 3 and SDH subunits, and increased succinate levels. The gene and protein expression of SUCNR1 also decreased in the livers of mice fed the diet, but no signs of oxidative damage were observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ke Cao, Jie Xu, Wenli Cao, Xueqiang Wang, Weiqiang Lv, Mengqi Zeng, Xuan Zou, Jiankang Liu, Zhihui Feng
Summary: Mitochondrial succinate dehydrogenase (SDH) is an enzyme complex that plays a crucial role in regulating mitochondrial metabolism and human health. Recent studies have revealed the dynamic involvement of SDH assembly process in various diseases. Perturbation of SDH assembly in different tissues can lead to distinct pathophysiological changes, highlighting the importance of understanding the intricate SDH assembly process in human health and diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Mohammad Golam Sabbir, Carla G. Taylor, Peter Zahradka
Summary: This study revealed that CAMKK2 deletion inhibits cellular respiration in both HEK293 and HepG2 cells, leading to a shift towards aerobic glycolysis. Additionally, isolated mitochondria showed cell-type-specific enhancement or dampening of respiratory kinetics under CAMKK2 deletion conditions.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Multidisciplinary Sciences
Xueqiang Wang, Xing Zhang, Ke Cao, Mengqi Zeng, Xuyang Fu, Adi Zheng, Feng Zhang, Feng Gao, Xuan Zou, Hao Li, Min Li, Weiqiang Lv, Jie Xu, Jiangang Long, Weijin Zang, Jinghai Chen, Jian Ding, Jiankang Liu, Zhihui Feng
Summary: This study reveals the importance of succinate dehydrogenase complex II assembly in the development of dilated cardiomyopathy and provides insights into potential therapeutic interventions for heart diseases.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Cameron A. Schmidt
Summary: Mitochondria play a central role in the physiology and survival of eukaryotic cells. Small molecules that modulate mitochondrial metabolism can have complex systemic effects. This article reviews the effects of prescription drugs on mitochondrial metabolism, discusses qualitative models of drug-mitochondria interactions, and highlights specific drug classes for further discussion.
BIOSCIENCE REPORTS
(2022)
Article
Plant Sciences
Manuel Balparda, Marlene Elsasser, Mariana B. Badia, Jonas Giese, Anastasiia Bovdilova, Meike Huedig, Lisa Reinmuth, Jurgen Eirich, Markus Schwarzlaender, Iris Finkemeier, Mareike Schallenberg-Ruedinger, Veronica G. Maurino
Summary: The study reveals that lysine acetylation is a highly conserved regulatory strategy in plants to directly modulate metabolic function. It is found that lysine acetylation serves as a common approach to finely adjust the activity of central metabolic enzymes in plants, impacting their acclimation capacity.
Article
Medicine, Research & Experimental
Bo Zhou, Arianne Caudal, Xiaoting Tang, Juan D. Chavez, Timothy S. McMillen, Andrew Keller, Outi Villet, Mingyue Zhao, Yaxin Liu, Julia Ritterhoff, Pei Wang, Stephen C. Kolwicz, Wang Wang, James E. Bruce, Rong Tian
Summary: This study reveals the mechanism of metabolic rewiring in hypertrophied and failing hearts, showing that increased expression of ATPIF1 leads to a switch towards glucose metabolism and glycolysis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biology
Rabina Mainali, Manal Zabalawi, David Long, Nancy Buechler, Ellen Quillen, Chia-Chi Key, Xuewei Zhu, John S. Parks, Cristina Furdui, Peter W. Stacpoole, Jennifer Martinez, Charles E. McCall, Matthew A. Quinn
Summary: Metabolic reprogramming occurs in the immune system during sepsis, particularly in the liver, with changes in lipid metabolism, mitochondrial energy, and redox balance. Targeting mitochondrial energy metabolism can rebalance the transcriptional and metabolic manifestations of sepsis in the liver.
Article
Plant Sciences
Ying Li, Katharina Belt, Saad F. Alqahtani, Saurabh Saha, Ricarda Fenske, Olivier Van Aken, James Whelan, A. Harvey Millar, Monika W. Murcha, Shaobai Huang
Summary: This study reveals the critical role of SDHAF1 in maintaining glycolysis and mitochondrial respiration. SDHAF1 participates in the biogenesis of complex II by interacting with SDH2 and HSCB.
Article
Endocrinology & Metabolism
Hyunbae Kim, Zhiyao Fu, Zhao Yang, Zhenfeng Song, El Hussain Shamsa, Thangal Yumnamcha, Shengyi Sun, Wanqing Liu, Ahmed S. Ibrahim, Nathan R. Qi, Ren Zhang, Kezhong Zhang
Summary: The mitochondrial nicotinamide adenine dinucleotide kinase (MNADK) plays an important role in regulating energy metabolism and maintaining metabolic homeostasis. MNADK deficiency is associated with metabolic diseases such as type-2 diabetes, non-alcoholic fatty liver disease, and hepatocellular carcinoma. Loss of MNADK reduces fat oxidation and energy expenditure, and leads to hepatic insulin resistance and glucose intolerance. Moreover, MNADK deficiency results in decreased mitochondrial NADP(H) and increased cellular reactive oxygen species.
MOLECULAR METABOLISM
(2022)
Article
Multidisciplinary Sciences
Christian Harry Allen, Duale Ahmed, Olivia Raiche-Tanner, Vinita Chauhan, Leila Mostaco-Guidolin, Edana Cassol, Sangeeta Murugkar
Summary: The study utilized TPEF imaging to investigate changes in mitochondrial function and organization following bacterial and viral stimuli, revealing cell type dependent responses with primary cells showing higher FAD levels and oxygen consumption rates, indicating potential dependence on mitochondrial metabolism. Additionally, FAD-TPEF intensity was found to be a better predictor of mitochondrial activity and localization in stimulated macrophages.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Leah K. Billingham, Joshua S. Stoolman, Karthik Vasan, Arianne E. Rodriguez, Taylor A. Poor, Marten Szibor, Howard T. Jacobs, Colleen R. Reczek, Aida Rashidi, Peng Zhang, Jason Miska, Navdeep S. Chandel
Summary: The study found that inhibitors of different complexes in the mitochondrial electron transport chain (ETC) can prevent the activation of the NLRP3 inflammasome, and the expression of specific enzymes from yeast or tunicates can rescue the activation of NLRP3 inflammasome in the absence of functional mitochondrial complex I or III. Metabolomics revealed that ATP generation through the phosphocreatine-dependent mechanism sustains the activation of NLRP3 inflammasome.
Review
Medicine, Research & Experimental
Russel J. Reiter, Ramaswamy Sharma, Carmen Rodriguez, Vanesa Martin, Sergio Rosales-Corral, Debora Aparecida Pires de Campos Zuccari, Luiz Gustavo de Almeida Chuffa
Summary: This paper explores the relationship between endogenous melatonin and solid tumors, highlighting the potential of using melatonin to influence cancer cell metabolism. It suggests that solid tumors exhibit a healthier metabolic state at night, potentially reducing proliferation and invasiveness. The paper also proposes using melatonin in a time-sensitive treatment paradigm and combining it with traditional chemotherapy for improved outcomes in cancer treatment.
Review
Cell Biology
Zakery N. Baker, Patrick Forny, David J. Pagliarini
Summary: Mitochondria are multifunctional organelles with diverse roles in cellular processes, bioenergetics, and disease. The development of a comprehensive mitochondrial protein map has revolutionized our understanding of mitochondrial biology and its clinical implications. Advances in technology and computational methods continue to refine this map, providing insights into new proteins and their functions.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)