Article
Multidisciplinary Sciences
Kei Hamazaki, Yutaka J. Matsuoka, Taiki Yamaji, Norie Sawada, Masaru Mimura, Shoko Nozaki, Ryo Shikimoto, Shoichiro Tsugane
Summary: This study found no association between plasma phospholipid n-3 PUFAs and the risk of MDD in the elderly Japanese population.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Varinderpal S. Dhillon, Permal Deo, Ann Chua, Phil Thomas, Michael Fenech
Summary: The study investigated the relationship between red blood cell fatty acid status and lymphocyte telomere length (LTL) in 174 healthy older South Australians. Results showed that saturated and monounsaturated fatty acids were negatively associated with LTL, while polyunsaturated fatty acids, particularly arachidonic acid (C20:4n-6), were positively correlated with LTL. Further research is warranted into the significant association of fatty acids, especially C20:4n-6, with telomere length.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Permal Deo, Varinderpal S. Dhillon, Philip Thomas, Michael Fenech
Summary: The study found a negative association between saturated fatty acids and a blood biomarker of AGE, while unsaturated fatty acids showed a positive association with it. However, these associations weakened after adjusting for age, BMI, and gender.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Sai Zhang, Xiaohong Chen, Biswarup Sen, Mohan Bai, Yaodong He, Guangyi Wang
Summary: Species of Schizochytrium are well known for their ability to produce lipids intracellularly. In this study, seven different natural antioxidants were evaluated for their effects on lipid accumulation in Schizochytrium sp. PKU#Mn4. Mannitol showed the best increment in total fatty acids concentration, with interactions between mannitol and ascorbic acid resulting in increased saturated and polyunsaturated fatty acids concentrations. This study provides insights into strategies for improving lipid accumulation in thraustochytrids using exogenous antioxidants and the underlying mechanisms.
Article
Biochemistry & Molecular Biology
Joan Bestard-Escalas, Rebeca Reigada, Jose Reyes, Paloma de la Torre, Gerhard Liebisch, Gwendolyn Barcelo-Coblijn
Summary: The analysis of plasma exosome lipid fingerprint can provide new non-invasive biomarkers for CRC. The lipid composition in pathological patients shows significant changes, and a certain ratio has the potential to discriminate between healthy and pathological patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Elom K. Aglago, Neil Murphy, Inge Huybrechts, Genevieve Nicolas, Corinne Casagrande, Veronika Fedirko, Elisabete Weiderpass, Joseph A. Rothwell, Christina C. Dahm, Anja Olsen, Anne Tjonneland, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Giovanna Masala, Claudia Agnoli, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Bas H. Bueno-de-Mesquita, Jeroen W. G. Derksen, Guri Skeie, Inger Torhild Gram, Magritt Brustad, Paula Jakszyn, Maria-Jose Sanchez, Pilar Amiano, Jose Maria Huerta, Ulrika Ericson, Maria Wennberg, Aurora Perez-Cornago, Alicia K. Heath, Mazda Jenab, Veronique Chajes, Marc J. Gunter
Summary: Epidemiologic studies suggest that total and individual saturated fatty acids as well as fatty acids of industrial origin may play a role in the etiology of CRC. Both dietary and plasma levels of myristic acid were inversely associated with colon cancer risk, indicating a need for further research.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Nutrition & Dietetics
Ling-Jun Li, Ruochen Du, Marion Ouidir, Ruijin Lu, Zhen Chen, Natalie L. Weir, Michael Y. Tsai, Paul S. Albert, Cuilin Zhang
Summary: Saturated fatty acids (SFAs) during pregnancy have an impact on metabolic programming and fetal growth. In this study, plasma phospholipid SFAs were measured in early pregnancy and fetal growth was monitored. It was found that even-chain and very long even-chain SFAs were negatively associated, while odd-chain SFAs were positively associated with fetal weight and size. Pentadecanoic acid (15:0) in the highest tertile showed a greater fetal weight and size compared to the lowest tertile. These findings suggest the potential use of an alternative high-fat diet rich in odd-chain SFAs for optimal fetal growth.
Article
Soil Science
Jinhong He, Xiangping Tan, Yanxia Nie, Lei Ma, Weiping Zhou, Weijun Shen
Summary: Research found that forest soil microorganisms acclimate to temperature variations by changing the lipid composition of their cell membranes. Saturated fatty acids increase while unsaturated fatty acids decrease with increasing temperature. The long-term warming may result in larger alterations in lipid constitute of soil microbial membranes compared to short-term incubation temperature gradient.
SOIL BIOLOGY & BIOCHEMISTRY
(2023)
Article
Nutrition & Dietetics
Emily Wang, Yeyi Zhu, Rana F. Chehab, Jing Wu, Stefanie N. Hinkle, Natalie L. Weir, Andrew A. Bremer, Jiaxi Yang, Zhen Chen, Michael Y. Tsai, Cuilin Zhang
Summary: The study found that mid-to-late pregnancy is a critical period for fetal growth, with plasma DHA and Delta 5-desaturase activity positively associated with neonatal anthropometric measures.
Article
Medicine, Research & Experimental
Xin Wang, Rui Ma, Rongcan Shi, Hui Qin, Wenjuan Chen, Zengyang Yu, Yangfeng Ding, Chen Peng, Yuling Shi
Summary: Sex differences exist in both disease severity and plasma PUFAs levels. The association between PUFAs and psoriasis severity varies between males and females, and should be taken into consideration in future studies on the clinical application of PUFAs in psoriasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Inge Huybrechts, Inarie Jacobs, Elom K. Aglago, Sahar Yammine, Michele Matta, Julie A. Schmidt, Corinne Casagrande, Genevieve Nicolas, Carine Biessy, Heleen Van Puyvelde, Augustin Scalbert, Jeroen W. G. Derksen, Yvonne T. van der Schouw, Sara Grioni, Pilar Amiano, Jytte Halkjaer, Anne Tjonneland, Jose M. Huerta, Leila Lujan-Barroso, Domenico Palli, Marc J. Gunter, Aurora Perez-Cornago, Veronique Chajes
Summary: This study aims to investigate the relationship between dietary fatty acid (FA) intake and plasma phospholipid (PL) FA levels in the EPIC cohort. Dietary intake of 60 individual FAs was estimated using validated questionnaires, and plasma PL FA concentrations were measured in non-fasting venous plasma samples. The results showed moderate positive correlations between FA intakes and plasma PL FA levels for certain FAs, especially for health-enhancing long-chain polyunsaturated FAs and health-deteriorating trans-FA.
Article
Biochemistry & Molecular Biology
Miguel D. Ferrer, Clara Reynes, Margalida Monserrat-Mesquida, Magdalena Quetglas-Llabres, Cristina Bouzas, Silvia Garcia, David Mateos, Miguel Casares, Cristina Gomez, Lucia Ugarriza, Josep A. Tur, Antoni Sureda, Antoni Pons
Summary: Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of hepatic fat. This study investigated the plasma levels of oxylipins, free polyunsaturated fatty acids (PUFA), and markers of lipid peroxidation in NAFLD patients. The results showed that severe NAFLD patients had higher levels of oxylipins, saturated oxylipins, and free PUFA, suggesting an association between inflammation, fatty acid oxidation dysregulation, and NAFLD progression.
Article
Medicine, General & Internal
Ling-Jun Li, Jing Wu, Zhen Chen, Natalie L. Weir, Michael Y. Tsai, Paul Albert, Cuilin Zhang
Summary: This study found that higher levels of plasma DHA and ALA in early pregnancy were associated with increased fetal size and weight throughout subsequent pregnancy.
Article
Biochemistry & Molecular Biology
Dolores Camacho-Munoz, Magdalena Kiezel-Tsugunova, Orsolya Kiss, Mohib Uddin, Mattias Sunden, Maria Ryaboshapkina, Lars Lind, Jan Oscarsson, Anna Nicolaou
Summary: In this study, the effects of Fibrates and omega-3 polyunsaturated acids on plasma levels of bioactive lipid mediators in patients with obese non-alcoholic fatty liver and hypertriglyceridemia were investigated. The results showed that these two drugs have different effects on the plasma mediator lipidome, with omega-3 promoting lipid mediators potentially affecting chronic inflammation, while Fibrates mainly reducing ceramides. These findings suggest that both treatments could alleviate chronic inflammation and possibly impact disease outcomes, independent of triglyceride reduction.
Article
Psychiatry
Lian Yang, Mei Zhou, Lingli Li, Ping Luo, Wenliang Fan, Juanjuan Xu, Qing Chen, Feng Pan, Ping Lei, Chuansheng Zheng, Yang Jin
Summary: This study explored the associations between cerebral white matter alterations, mental health status, and metabolism in recovered COVID-19 patients. Findings revealed multiple changes in both white matter integrity and plasma metabolomics, potentially explaining the deteriorated mental health in these patients. These results provide potential biomarkers for mental health evaluation and novel therapeutic targets for recovered COVID-19 patients.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Monica Emili Garcia-Segura, Brenan R. Durainayagam, Sonia Liggi, Goncalo Graca, Beatriz Jimenez, Abbas Dehghan, Ioanna Tzoulaki, Ibrahim Karaman, Paul Elliott, Julian L. Griffin
Summary: This study analyzed the differentially expressed multi-omics elements in mouse models of Alzheimer's disease (AD) using genome-wide association studies (GWAS), transcriptomics, and proteomics data. It identified lipid and bioenergetic metabolic pathways that are significantly enriched in the AD multi-omics data sets. Microglia and astrocytes were found to be significantly enriched in the lipid-predominant AD-metabolic transcriptome.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Gastroenterology & Hepatology
Emily W. Lopes, Simon S. M. Chan, Mingyang Song, Jonas F. Ludvigsson, Niclas Hakansson, Paul Lochhead, Allan Clark, Kristin E. Burke, Ashwin N. Ananthakrishnan, Amanda J. Cross, Domenico Palli, Manuela M. Bergmann, James M. Richter, Andrew T. Chan, Ola Olen, Alicja Wolk, Hamed Khalili
Summary: This study aimed to estimate the proportion of cases of Crohn's disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors. Using several cohorts in the US and Europe, the researchers created modifiable risk scores and healthy lifestyle scores, and found that a significant number of CD and UC cases could be prevented through lifestyle modification.
Article
Biochemistry & Molecular Biology
Samuel Furse, Hannah L. Morgan, Albert Koulman, Adam J. Watkins
Summary: There is evidence to suggest that poor paternal diet during conception can increase the risk of offspring developing metabolic diseases later in life. This study found that a low protein-high carbohydrate diet in male mice affected the lipid profiles of their offspring's hearts and brains. These effects were observed from a young age and varied between sexes. These findings highlight the importance of paternal diet in the development of non-communicable diseases in offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Spyros Vernardis, Vadim Demichev, Oliver Lemke, Nana-Maria Gruening, Christoph Messner, Matt White, Maik Pietzner, Alina Peluso, Tinh-Hai Collet, Elana Henning, Christoph Gille, Archie Campbell, Caroline Hayward, David J. Porteous, Riccardo E. Marioni, Michael Muelleder, Aleksej Zelezniak, Nicholas J. Wareham, Claudia Langenberg, I. Sadaf Farooqi, Markus Ralser
Summary: Humans exhibit profound responses to changes in diet, making it important to study the nutritional responses in depth. This study used high-throughput mass spectrometry to investigate the impact of caloric restriction and a glucose challenge on the plasma proteome, identifying proteins that correlate with metabolome and endocrine changes. The study highlights the role of APOC1 as a dominant nutritional responder and emphasizes the interdependency between acute nutritional response proteins and the endocrine system.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Luis Herrera-Marcos, Roberto Martinez-Beamonte, Carmen Arnal, Cristina Barranquero, Juan J. Puente-Lanzarote, Tania Herrero-Continente, Jose M. Lou-Bonafonte, Gonzalo Gonzalo-Romeo, Gabriele Mocciaro, Benjamin Jenkins, Joaquin C. Surra, Maria J. Rodriguez-Yoldi, Juan Carlos Burillo, Roberto Lasheras, Agustin Garcia-Gil, Antonio Guemes, Albert Koulman, Jesus Osada
Summary: This study investigated the effects of squalene on a porcine model of hepatic steatohepatitis and the associated lipidomic changes. The results showed that supplementation of a steatotic diet with 0.5% squalene for one month led to a decrease in hepatic triglyceride content and area of hepatic lipid droplets, without affecting cholesterol content or fiber areas. However, the ballooning score was increased and correlated with hepatic squalene content. Furthermore, squalene supplementation altered the hepatic and plasma lipidomic profiles, as well as the expression of non-coding RNA and the anti-inflammatory interleukin.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Hugo J. R. Fernandes, Josh P. P. Kent, Michaela Bruntraeger, Andrew R. R. Bassett, Albert Koulman, Emmanouil Metzakopian, Stuart G. G. Snowden
Summary: The metabolic basis of Parkinson's disease is poorly understood, but it is known that mitochondrial and endoplasmic reticulum stress play a role in the pathology. In this study, the effects of mitochondrial and ER stress on dopamine neuron metabolism were examined, and it was found that both stresses caused significant dysregulation of metabolism, with triglyceride accumulation being a major driver. Understanding the mechanisms of triglyceride accumulation could lead to new therapeutic approaches.
Article
Endocrinology & Metabolism
Jody C. Hoenink, Thomas Burgoine, Soren Brage, Nita Forouhi, Simon J. Griffin, Pablo Monsivais, Nicholas J. Wareham, Amy Ahern, Jean Adams
Summary: This study investigates the association between exposure to takeaway outlets and eating behavior traits in relation to takeaway food consumption and adiposity. The findings suggest that higher exposure to takeaway outlets and certain eating behavior traits were independently associated with greater takeaway consumption and body fat percentage. However, the influence of eating behavior traits on the association between takeaway outlet exposure and outcomes was not significant. Therefore, interventions at both the individual and environmental levels are necessary to address unhealthy diets comprehensively.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Medicine, General & Internal
Jakub G. D. Sobiecki, Fumiaki Imamura, Courtney R. Davis, Stephen J. Sharp, Albert Koulman, Jonathan M. Hodgson, Marcela Guevara, Matthias B. Schulze, Ju-Sheng Zheng, Claudia Agnoli, Catalina Bonet, Sandra M. Colorado-Yohar, Guy Fagherazzi, Paul W. Franks, Thomas E. Gundersen, Franziska Jannasch, Rudolf Kaaks, Verena Katzke, Esther Molina-Montes, Peter M. Nilsson, Domenico Palli, Salvatore Panico, Keren Papier, Olov Rolandsson, Carlotta Sacerdote, Anne Tjonneland, Tammy Y. N. Tong, Yvonne T. van der Schouw, John Danesh, Adam S. Butterworth, Elio Riboli, Karen J. Murphy, Nicholas J. Wareham, Nita G. Forouhi
Summary: A study found that adherence to the Mediterranean diet lowered the risk of type 2 diabetes, and objectively assessed adherence had a stronger association than self-reported adherence. The study used biomarkers to assess the actual effectiveness of the Mediterranean diet and found that higher adherence was associated with lower incidence of type 2 diabetes. This research is of importance in reducing the risk of type 2 diabetes and reducing the burden on the population.
Article
Multidisciplinary Sciences
Lina Cai, Tomas Gonzales, Eleanor Wheeler, Nicola D. Kerrison, Felix R. Day, Claudia Langenberg, John R. B. Perry, Soren Brage, Nicholas J. Wareham
Summary: Higher cardiorespiratory fitness is associated with lower risk of type 2 diabetes. Genetic determinants in cardiorespiratory fitness and candidate genes related to cardiac muscle development and muscle contractility were identified. Higher genetically predicted fitness is causally associated with lower risk of type 2 diabetes independent of adiposity.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Junqing Xie, Yuliang Feng, Danielle Newby, Bang Zheng, Qi Feng, Albert Prats-Uribe, Chunxiao Li, Nicholas J. Wareham, R. Paredes, Daniel Prieto-Alhambra
Summary: The study examined the association between genetic predisposition, lifestyle factors, and the risk of post-COVID-19 cardiovascular and thromboembolic events (CVE). The results showed that higher polygenic risk scores were associated with increased risks of atrial fibrillation, coronary artery disease, venous thromboembolism, and ischemic stroke. However, a healthier lifestyle was consistently associated with a reduction in all outcomes. These findings highlight the independent effects of host genetics and lifestyle on the occurrence of CVE complications in COVID-19 patients.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Andrea Soria-Gondek, Pablo Fernandez-Garcia, Lorena Gonzalez, Marjorie Reyes-Farias, Marta Murillo, Aina Valls, Nativitat Real, Silvia Pellitero, Jordi Tarasco, Benjamin Jenkins, Maria Galan, Francesc Villarroya, Albert Koulman, Patricia Corrales, Antonio Vidal-Puig, Ruben Cereijo, David Sanchez-Infantes
Summary: The objective of this study was to assess the circulating lipidome of children and adults with obesity before and after clinical interventions. The findings showed that certain lipid species increased in abundance in both children and adults, while others decreased. There was a specific set of lipid species that were regulated after clinical interventions in both age groups, suggesting a core circulating lipid profile indicative of obesity development and improvement.
Article
Health Care Sciences & Services
Kirsten L. Rennie, Emma R. Lawlor, Arrash Yassaee, Adam Booth, Kate Westgate, Stephen J. Sharp, Carina S. B. Tyrrell, Mert Aral, Nicholas J. Wareham
Summary: This study investigated participant characteristics associated with engagement in digital biomarker collection through a smartphone app. The results showed that older age groups and certain occupations were associated with higher engagement, while working, smoking, overweight or obesity, and high perceived stress were associated with lower engagement. The study also provided key recommendations to improve engagement in population-based health research.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Tiberiu A. Pana, Mamas A. Mamas, Nicholas J. Wareham, Kay-Tee Khaw, Dana K. Dawson, Phyo K. Myint
Summary: This study aims to understand the sex-specific lifetime trajectories of different heart and circulatory disorders and their relationship with death from heart disease. The results of the study show that men have a higher lifetime risk of heart and circulatory disorders compared with women. Men are more likely to experience myocardial infarction as the first manifestation, while women are more likely to develop atrial fibrillation and stroke after a certain age. The excess risk of death from heart disease observed in men with pre-existing heart disease is attenuated compared with those free of heart disease at baseline. In conclusion, our study highlights the marked sex disparities in heart disease and death over the very long-term, emphasizing the need for tailored heart disease prevention efforts for both men and women.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
