Article
Chemistry, Multidisciplinary
Sho Takahashi, Shiki Yagai
Summary: This study demonstrates an example of thermodynamically controlled random supramolecular copolymerization. By forming six-membered hydrogen-bonded rosette intermediates, the random copolymerization of two monomers with distinct molecular structures is achieved. The experimental results reveal the homopolymerization of one monomer in the high-temperature region and the incorporation of the other monomer in the medium-temperature region to form supramolecular copolymers.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biotechnology & Applied Microbiology
Niels Gallas, Xiaoxu Li, Edda von Roepenack-Lahaye, Niklas Schandry, Yuxin Jiang, Dousheng Wu, Thomas Lahaye
Summary: Ralstonia solanacearum is a bacterial plant pathogen complex that has evolved through the split of a founder population during continental drift. The RipTAL proteins in this complex have evolved in geographically separated phylotypes and may have different functions. Research has shown that RipTALs may target specific DNA binding elements to activate downstream genes and affect host plants. Additionally, genetic engineering using the RipTAL-binding motif can enhance crop resistance against Ralstonia solanacearum.
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Article
Multidisciplinary Sciences
C. Garrett Rappazzo, Longping Tse, Chengzi Kaku, Daniel Wrapp, Mrunal Sakharkar, Deli Huang, Laura M. Deveau, Thomas J. Yockachonis, Andrew S. Herbert, Michael B. Battles, Cecilia M. O'Brien, Michael E. Brown, James C. Geoghegan, Jonathan Belk, Linghang Peng, Linlin Yang, Yixuan Hou, Trevor D. Scobey, Dennis R. Burton, David Nemazee, John M. Dye, James E. Voss, Bronwyn M. Gunn, Jason S. McLellan, Ralph S. Baric, Lisa E. Gralinski, Laura M. Walker
Summary: The engineered antibody ADG-2 shows enhanced neutralization breadth and potency against a wide range of sarbecoviruses, providing complete protection in SARS and COVID-19 mouse models. Structural and biochemical studies reveal that ADG-2 targets a highly conserved epitope through a unique angle of approach.
Article
Cell Biology
Melvys Valledor, Meg Byron, Brett Dumas, Dawn M. Carone, Lisa L. Hall, Jeanne B. Lawrence
Summary: XIST RNA triggers widespread gene silencing and chromosome condensation. Sparse XIST transcripts immediately impact chromatin structure, leading to the formation of dense zones and subsequent gene silencing. The A-repeat plays a critical role in gene silencing by facilitating sustained histone deacetylation.
Article
Engineering, Chemical
Shoufeng Tang, Huilin Liu, Eryu Zhu, Tongtong Zhao, Zetao Wang, Tifeng Jiao, Qingrui Zhang, Deling Yuan
Summary: This study established a boosted PDS/Fe2+ Fenton-like system using PCA as a complexing reagent, which efficiently eliminated typical dyes and antibiotics. The system performed well under various conditions and showed that sulfate radical was the dominant active substance responsible for pollutant removal.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Virology
Jiahui Zou, Shan Tian, Yinxing Zhu, Yanqing Cheng, Meijun Jiang, Shaoyu Tu, Meilin Jin, Huanchun Chen, Hongbo Zhou
Summary: In this study, Prohibitin1 (PHB1) was identified as a negative regulator of innate immune responses by inhibiting the nuclear translocation of IRF3. This finding contributes to understanding the regulation of IRF3 and reveals a novel role of PHB1 in host innate immunity.
JOURNAL OF VIROLOGY
(2023)
Article
Transplantation
M. Adela Mansilla, Ramakrishna R. Sompallae, Carla J. Nishimura, Anne E. Kwitek, Mycah J. Kimble, Margaret E. Freese, Colleen A. Campbell, Richard J. Smith, Christie P. Thomas
Summary: Genetic testing was found to be valuable in the evaluation of renal patients, with a high diagnostic rate in patients and the potential to change clinical diagnosis. The study highlights the importance of incorporating broad genetic testing in the management of kidney diseases.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Polymer Science
Thuy T. Cao, Hiroshi Yabu, Do S. Huh
Summary: By combining the breath figure technique and layer-by-layer solution casting process, a hierarchical flower-like ordered arrangement of pores in porous films was explored successfully. The formation mechanism of flower-like ordered hierarchical porous structure was proposed based on deep experimental observation.
Article
Biology
Jose A. Fernandez-Leon, Gerardo Acosta
Summary: By simulating the changes in non-variational free energy of a neural network during sleep transitions, the study investigated the role of slow wave frequencies and thalamic input in the self-organization process of the network. Results showed that the network exhibited characteristic differences under low and high thalamic drive, attributed to spike timing dependent plasticity.
Review
Rehabilitation
Luz H. Lugo-Agudelo, Kelly Mariana Cruz Sarmiento, Maria Alejandra Spir Brunal, Juan Carlos Velasquez Correa, Ana Maria P. O. S. A. D. A. Borrero, Luisa Fernanda Mesa Franco, Rosarita Di Dio Castagna Ianini, Paola Andrea Ramirez Perez Lis, Claudia Marcela Velez, Daniel F. Patino Lugo, Christoph Gutenbrunner
Summary: This article summarizes the recommendations for adaptations in the provision of rehabilitation services proposed by scientific and professional rehabilitation organizations to avoid disruptions and delays in patients' rehabilitation process due to COVID-19. The results are presented in four categories: adequacy of inpatient and outpatient services, recommendations for preventing the spread of COVID-19, and regulatory standards and positions expressed by organizations. Health systems worldwide are rapidly learning from reorganization efforts to provide rehabilitation for patients recovering from acute or chronic conditions, as well as in the rapid response to rehabilitating survivors of COVID-19 and preventing contagion among healthcare providers.
JOURNAL OF REHABILITATION MEDICINE
(2021)
Article
Plant Sciences
Ming Xu, Guangyao Li, Yan Guo, Yuqi Gao, Lihua Zhu, Zhaoyang Liu, Runze Tian, Chen Gao, Pengliang Han, Ning Wang, Feiran Guo, Jiyuan Bao, Conghui Jia, Hao Feng, Lili Huang
Summary: This study reveals that the milRNA Vm-milR1 from the apple tree pathogen Valsa mali can suppress the host immune response by silencing host receptor-like kinase genes. Overexpression of these genes enhances apple resistance to the pathogen, while knockdown of the genes compromises the host resistance.
Article
Biochemistry & Molecular Biology
Simone Bini, Valeria Pecce, Alessia Di Costanzo, Luca Polito, Ameneh Ghadiri, Ilenia Minicocci, Federica Tambaro, Stella Covino, Marcello Arca, Laura D'Erasmo
Summary: This study found that ANGPTL3-Fld stimulates lipolysis in adipocytes through the MAPK-ERK pathway. This pathway is different from the canonical beta-adrenergic stimulus. ANGPTL3-Fld appears to facilitate lipolysis in adipocytes by signaling through the PDGFR beta-PLC gamma-AMPK axis.
Article
Cell Biology
Shuai Yu, Rui Zhang, Qiaoyan Shen, Zhenshuo Zhu, Juqing Zhang, Xiaolong Wu, Wenxu Zhao, Na Li, Fan Yang, Hongjiang Wei, Jinlian Hua
Summary: By overexpressing the transcription factor ESRRB, flat, monolayered piPSCs were created with enhanced chimeric capacity into the trophectoderm. ESRRB directly regulates the expressions of trophoblast stem cell markers, and its cooperation with OCT4 facilitates the transition from pluripotent state to trophoblast-like state.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Physics, Fluids & Plasmas
R. Mark Bradley, Tejas Sharath
Summary: The study shows that nearly defect-free ripples with a sawtooth profile can form on the surface under low-energy ion bombardment, and the ripples coarsen with time passing.
Article
Chemistry, Multidisciplinary
Anthony Vial, Cyntia Taveneau, Luca Costa, Brieuc Chauvin, Hussein Nasrallah, Cedric Godefroy, Patrice Dosset, Herve Isambert, Kien Xuan Ngo, Stephanie Mangenot, Daniel Levy, Aurelie Bertin, Pierre-Emmanuel Milhiet
Summary: Septins are cytoskeletal filaments essential for cell division in eukaryotes, often localized at micrometric Gaussian curvatures where they assemble into ring-like structures. Their specific interaction with inositol phospholipids enriched at the inner leaflet of the plasma membrane is crucial. Through imaging techniques, it has been demonstrated that short septin rods can destabilize supported lipid bilayers and reshape the membrane, forming 3D structures without the need for long filaments.
Article
Biochemistry & Molecular Biology
Moshe Goldsmith, Shiri Barad, Maor Knafo, Alon Savidor, Shifra Ben-Dor, Alexander Brandis, Tevie Mehlman, Yoav Peleg, Shira Albeck, Orly Dym, Efrat Ben-Zeev, Ranjit S. Barbole, Asaph Aharoni, Ziv Reich
Summary: Grass pea is a commonly grown grain legume with high nutritional value. However, it produces a neurotoxic compound that can cause severe neurological disorders. In this study, the enzyme responsible for the formation of this compound, beta-ODAP synthase (BOS), was identified and characterized. The expression of BOS in the presence of its substrates was found to be sufficient for beta-ODAP production. This discovery may help in the development of grass pea cultivars that are safe for consumption.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Shahar Rezenman, Maor Knafo, Ivgeni Tsigalnitski, Shiri Barad, Ghil Jona, Dikla Levi, Orly Dym, Ziv Reich, Ruti Kapon
Summary: Cellular lineage tracking is a valuable tool for studying heterogeneity, evolution, and fitness in populations. However, existing methods have limitations in terms of specificity, cost, and repeatability. To overcome these challenges, we developed gUMI-BEAR, a modular and cost-effective method for high-resolution population tracking.