Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer
出版年份 2015 全文链接
标题
Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer
作者
关键词
Synthetic lethality, Mutual exclusivity, Context-dependent genetic vulnerabilities, Context-dependent oncogenes
出版物
Biology Direct
Volume 10, Issue 1, Pages -
出版商
Springer Nature
发表日期
2015-10-01
DOI
10.1186/s13062-015-0086-1
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification
- (2015) Charlotte KY Ng et al. GENOME BIOLOGY
- Predicting essential genes and synthetic lethality via influence propagation in signaling pathways of cancer cell fates
- (2015) Fan Zhang et al. Journal of Bioinformatics and Computational Biology
- Therapeutic targeting of tumor suppressor genes
- (2014) Luc G. T. Morris et al. CANCER
- Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality
- (2014) Livnat Jerby-Arnon et al. CELL
- Applying Synthetic Lethality for the Selective Targeting of Cancer
- (2014) Donal P. McLornan et al. NEW ENGLAND JOURNAL OF MEDICINE
- A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy
- (2014) C. Liu et al. NUCLEIC ACIDS RESEARCH
- Systematic tracking of dysregulated modules identifies novel genes in cancer
- (2013) Sriganesh Srihari et al. BIOINFORMATICS
- Identifying conserved protein complexes between species by constructing interolog networks
- (2013) Phi-Vu Nguyen et al. BMC BIOINFORMATICS
- The cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial design
- (2013) Ruth Thompson et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- A Comparative Genomic Approach for Identifying Synthetic Lethal Interactions in Human Cancer
- (2013) R. Deshpande et al. CANCER RESEARCH
- A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities
- (2013) F. J. Vizeacoumar et al. Molecular Systems Biology
- The Cancer Genome Atlas Pan-Cancer analysis project
- (2013) John N Weinstein et al. NATURE GENETICS
- Structure and dynamics of molecular networks: A novel paradigm of drug discovery
- (2013) Peter Csermely et al. PHARMACOLOGY & THERAPEUTICS
- Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer
- (2013) Balázs Győrffy et al. PLoS One
- Synthetic lethality between CCNE1 amplification and loss of BRCA1
- (2013) D. Etemadmoghadam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cancer Genome Landscapes
- (2013) B. Vogelstein et al. SCIENCE
- Saccharomyces cerevisiae Genetics Predicts Candidate Therapeutic Genetic Interactions at the Mammalian Replication Fork
- (2013) Derek M. van Pel et al. G3-Genes Genomes Genetics
- An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development
- (2013) Derek M. van Pel et al. PLoS Genetics
- DNA Double-Strand Break Repair as Determinant of Cellular Radiosensitivity to Killing and Target in Radiation Therapy
- (2013) Emil Mladenov et al. Frontiers in Oncology
- Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies
- (2012) Michael Steckel et al. CELL RESEARCH
- Screens, maps & networks: from genome sequences to personalized medicine
- (2012) Thomas Sandmann et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition
- (2012) Dai Horiuchi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Comprehensive molecular portraits of human breast tumours
- (2012) Daniel C. Koboldt et al. NATURE
- GenomeRNAi: a database for cell-based and in vivo RNAi phenotypes, 2013 update
- (2012) Esther E. Schmidt et al. NUCLEIC ACIDS RESEARCH
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- Understanding and predicting synthetic lethal genetic interactions in Saccharomyces cerevisiae using domain genetic interactions
- (2011) Bo Li et al. BMC Systems Biology
- Mutual exclusivity analysis identifies oncogenic network modules
- (2011) G. Ciriello et al. GENOME RESEARCH
- The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
- (2011) Thomas Helleday Molecular Oncology
- Integrated genomic analyses of ovarian carcinoma
- (2011) D. Bell et al. NATURE
- GOBO: Gene Expression-Based Outcome for Breast Cancer Online
- (2011) Markus Ringnér et al. PLoS One
- BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability
- (2011) A. Aly et al. Journal of Molecular Cell Biology
- Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
- (2011) Richard Marcotte et al. Cancer Discovery
- GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
- (2011) Craig H Mermel et al. GENOME BIOLOGY
- Synthetic lethality: General principles, utility and detection using genetic screens in human cells
- (2010) Sebastian M.B. Nijman FEBS LETTERS
- Evaluating Between-Pathway Models with Expression Data
- (2010) B.J. Hescott et al. JOURNAL OF COMPUTATIONAL BIOLOGY
- An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
- (2009) Balazs Györffy et al. BREAST CANCER RESEARCH AND TREATMENT
- Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
- (2009) Ji Luo et al. CELL
- Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair
- (2009) E. Bolderson et al. CLINICAL CANCER RESEARCH
- Fault Tolerance in Protein Interaction Networks: Stable Bipartite Subgraphs and Redundant Pathways
- (2009) Arthur Brady et al. PLoS One
- Systematic Mapping of Genetic Interaction Networks
- (2008) Scott J. Dixon et al. Annual Review of Genetics
- Mining protein networks for synthetic genetic interactions
- (2008) Sri R Paladugu et al. BMC BIOINFORMATICS
- Oncogene Addiction
- (2008) I. B. Weinstein et al. CANCER RESEARCH
- Finding friends and enemies in an enemies-only network: A graph diffusion kernel for predicting novel genetic interactions and co-complex membership from yeast genetic interactions
- (2008) Y. Qi et al. GENOME RESEARCH
- Modeling synthetic lethality
- (2008) Nolwenn Le Meur et al. GENOME BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started