Review
Infectious Diseases
Javier Cobo, Rosa Escudero-Sanchez
Summary: The treatment of prosthetic joint infections (PJIs) is a complex matter that requires integration of surgical, microbiological, and pharmacological aspects, while also taking into consideration each patient's individual context. In some cases, curative treatment may not be possible, leading to the importance of long-term antibiotic administration to suppress the infection.
Review
Infectious Diseases
Benjamin Le Vavasseur, Valerie Zeller
Summary: Prosthetic joint infection (PJI) is a severe complication after arthroplasty and its treatment involves a combination of surgical intervention and prolonged high-dose antibiotic therapy. The choice and quality of surgical procedures, microbiological diagnosis, and antibiotic therapy are crucial for the effectiveness of PJI management.
Article
Orthopedics
Rebecca G. Burr, Carlo K. Eikani, William H. Adams, William J. Hopkinson, Nicholas M. Brown
Summary: Chronic antibiotic suppression (CAS) is a reasonable treatment strategy for patients with persistent prosthetic joint infection (PJI) or multiple comorbidities. This study found that multiple changes to antibiotic regimen may lead to treatment failure in CAS, while total hip arthroplasty patients and patients with Gram-positive infections were less likely to require reoperation. The results of this study provide guidance for selecting appropriate treatment options for PJI patients.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Medicine, General & Internal
Martin H. Thornhill, Annabel Crum, Saleema Rex, Tony Stone, Richard Campbell, Mike Bradburn, Veronica Fibisan, Peter B. Lockhart, Bryan Springer, Larry M. Baddour, Jon Nicholl
Summary: This study investigated the temporal association between invasive dental procedures (IDP) and late prosthetic joint infection (LPJI) in England, where antibiotic prophylaxis has never been recommended for LPJI prevention, and found no significant association between IDP and subsequent LPJI, suggesting that administering antibiotic prophylaxis before IDP in patients with prosthetic joints may not be necessary.
Review
Medicine, General & Internal
Christos Koutserimpas, Ifigeneia Chamakioti, Stylianos Zervakis, Konstantinos Raptis, Kalliopi Alpantaki, Diamantis P. Kofteridis, Georgia Vrioni, George Samonis
Summary: Non-Candida fungal prosthetic joint infections pose a clinical challenge that requires a multidisciplinary approach. The combination of two-stage revision arthroplasty and prolonged antifungal treatment has been shown to be the standard of care in the reviewed cases.
Article
Medicine, General & Internal
Anne Spichler-Moffarah, Lee E. Rubin, Jenna A. Bernstein, Jane O'Bryan, Erik McDonald, Marjorie Golden
Summary: As the population ages and demand for total joint arthroplasty increases, the rates of periprosthetic joint infection are expected to increase in the geriatric population. However, there is a lack of studies comparing risk factors, etiology, management, and mortality of prosthetic joint infection in older patients. A single-center study comparing patients with first prosthetic joint infection found similar management regardless of age, but identified cardiac history as a significant risk factor in patients aged 75 and above.
AMERICAN JOURNAL OF MEDICINE
(2023)
Review
Infectious Diseases
Leanne Teoh, Monique C. Cheung, Stuart Dashper, Rodney James, Michael J. McCullough
Summary: This systematic review investigated antibiotic choices and regimens for managing acute dentoalveolar infections. Narrow-spectrum agents appeared to be as effective in healthy individuals, suggesting broad-spectrum antibiotics as first-line empirical therapy may be unnecessary. The primary factor in successful management of dentoalveolar abscesses was addressing the source of infection.
Review
Infectious Diseases
Alex Van Belkum, Marie-Francoise Gros, Tristan Ferry, Sebastien Lustig, Frederic Laurent, Geraldine Durand, Corinne Jay, Olivier Rochas, Christine C. Ginocchio
Summary: Whether interventions in BJI or PJI are surgical or chemo-therapeutic (antibiotics and bacteriophages included), prior sensitive and specific pathogen detection remains a therapy-substantiating necessity. Innovative tests for earlier and more sensitive and specific detection of bacterial pathogens in BJI are urgently needed.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2022)
Article
Orthopedics
Katy Kim, Mark Zhu, Brendan Coleman, Jacob Terrill Munro, Simon W. Young
Summary: Prosthetic joint infection (PJI) is a common complication following total knee arthroplasty (TKA). This study compared the microorganism and resistance profile between early and late PJI cases and recommended appropriate empiric antibiotics. The findings showed that early PJI cases were more resistant and polymicrobial, with coagulase-negative Staphylococci being the predominant organisms, while Staphylococcus aureus was more common in late PJI cases. The study recommended using Vancomycin with a Gram-negative agent for early infections and Cephazolin or Flucloxacillin for late infections. Antibiotics were advised to be withheld in intermediate infections until culture and sensitivity results were available.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Biochemistry & Molecular Biology
Martina Maritati, Marco Manfrini, Maria Rosa Iaquinta, Alessandro Trentini, Silva Seraceni, Matteo Guarino, Anna Costanzini, Roberto De Giorgio, Gustavo Alberto Zanoli, Alessandro Borghi, Elisa Mazzoni, Giuseppe De Rito, Carlo Contini
Summary: The aim of this study was to investigate the effect of Staphylococcus aureus (SA) producing the Panton-Valentine leukocidin (PVL) on the outcome of Prosthetic Joint Infection (PJI). The study found that SA strains positive for PVL genes resulted in a 100% failure rate in the treatment of acute PJI, while chronic PJI had a 100% eradication rate. Therefore, toxin research and targeted antibiotic therapy should be considered in the treatment of PJI caused by SA.
Article
Orthopedics
Helene Bocle, Jean-Philippe Lavigne, Nicolas Cellier, Julien Crouzet, Pascal Kouyoumdjian, Albert Sotto, Paul Loubet
Summary: The study compared the effect of early and late intravenous-to-oral antibiotic switch on treatment failure in Staphylococcus aureus prosthetic bone and joint infection, with results showing that early oral switch can reduce the treatment failure rate. Infections with methicillin-resistant S. aureus, obesity, and non-conventional empiric antibiotic therapy were significantly associated with treatment failure.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Medicine, General & Internal
Maria Eugenia Portillo, Ignacio Sancho
Summary: The article discusses the use of non-culture techniques in the diagnosis of prosthetic joint infections (PJI). Nucleic acid amplification and sequencing methods are described as useful tools for detecting and identifying pathogens. The new technologies have shown promise in improving the etiological diagnosis of PJI, but rigorous protocols are necessary to avoid contamination.
Article
Multidisciplinary Sciences
Tomoharu Ishida, Hideharu Hagiya, Hiroyuki Honda, Yasuhiro Nakano, Hiroko Ogawa, Mikako Obika, Keigo Ueda, Hitomi Kataoka, Yoshihisa Hanayama, Fumio Otsuka
Summary: Our study found that the antimicrobial prescription practices for outpatients with acute respiratory tract infections were favorable in terms of prescribing proportions. However, there was a tendency towards the overuse of broad-spectrum antimicrobials, indicating the need for further antimicrobial stewardship from a qualitative perspective in the outpatient setting.
Article
Infectious Diseases
Raquel Bandeira da Silva, Mauro Jose Salles
Summary: This study identified independent risk factors associated with multidrug-resistant GNB prosthetic joint infection, including revision arthroplasty, postoperative hematoma, previous orthopaedic infection, and early infection. Extensively drug-resistant GNB and comorbidities were independently associated with higher treatment failure rates in MDR-GNB PJI.
Article
Infectious Diseases
Gregoire Saltiel, Vanina Meyssonnier, Younes Kerroumi, Beate Heym, Olivier Lidove, Simon Marmor, Valerie Zeller
Summary: This study found that rifampicin combination therapy did not show significant advantage for patients undergoing exchange arthroplasty for chronic Ca-PJIs.
Article
Infectious Diseases
R. L. Roerdink, C. M. Douw, A. C. A. P. Leenders, R. S. Dekker, M. Dietvorst, C. J. M. Oosterbos, H. T. J. Roerdink, R. W. T. M. Kempen, L. P. A. Bom
Article
Orthopedics
Robin W. T. M. van Kempen, Janneke J. P. Schimmel, Gijs G. van Hellemondt, Hilde Vandenneucker, Ate B. Wymenga
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2013)
Article
Orthopedics
Nicole Heesakkers, Robin van Kempen, Rhijn Feith, Jan Hendriks, Wim Schreurs
INTERNATIONAL ORTHOPAEDICS
(2015)
Article
Orthopedics
Willemijn M. J. van Rooij, Karin C. M. Maas-van Weert, Robin W. T. M. van Kempen, Fred A. de Laat, Jan H. B. Geertzen
Summary: The study described a patient who underwent a modified Gritti-Stokes amputation for failed total knee arthroplasty and assessed the functional outcome 1 year post-surgery, showing good functional recovery in the patient.
PROSTHETICS AND ORTHOTICS INTERNATIONAL
(2021)
Article
Orthopedics
Sanne Korbee, Robin Van Kempen, Remco Van Wensen, Marieke Van Der Steen, Wai-Yan Liu
Summary: This study evaluated the psychometric properties of the Dutch version of HOOS-PS in revision hip arthroplasty patients. The results showed insufficient content validity of HOOS-PS in this patient population, indicating the need for minor changes. However, construct validity and interpretability showed positive results.
Article
Orthopedics
W. Y. Liu, M. C. van der Steen, R. J. A. van Wensen, R. W. T. M. van Kempen
Summary: This study examined recovery trajectories in revision knee arthroplasty patients over 12 months, identifying four different trajectories and demonstrating differences in pain, function, and quality of life among groups. Late and prolonged improvement groups showed improvement in all patient-reported outcome measures at 12 months, while the early improvement group did not report improvement in daily physical functioning but showed improvements in function and pain during activity.
JOURNAL OF EXPERIMENTAL ORTHOPAEDICS
(2021)
Article
Medicine, General & Internal
Claudia A. M. Lowik, Frank-Christiaan Wagenaar, Walter van der Weegen, Rudolf W. Poolman, Rob G. H. H. Nelissen, Sjoerd K. Bulstra, Yvette Pronk, Karin M. Vermeulen, Marjan Wouthuyzen-Bakker, Inge van den Akker-Scheek, Martin Stevens, Paul C. Jutte