Article
Endocrinology & Metabolism
Huiying Wang, Yunting Zhou, Xiaofang Zhai, Bo Ding, Ting Jing, Xiaofei Su, Huiqin Li, Jianhua Ma
Summary: The study aimed to evaluate glycemic control in adults with controlled type 2 diabetes mellitus using continuous glucose monitoring system during Basalin or Lantus administration. Lantus-treated patients showed lower 24-hour MBG, MAGE, and SDBG compared to the Basalin group. Insulin glargine Lantus may be a better choice for T2DM patients with HbA1c <= 7%.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Lalantha Leelarathna, Mark L. L. Evans, Sankalpa Neupane, Gerry Rayman, Sarah Lumley, Iain Cranston, Parth Narendran, Katharine Barnard-Kelly, Christopher J. J. Sutton, Rachel A. A. Elliott, Vicky P. P. Taxiarchi, Georgios Gkountouras, Matthew Burns, Womba Mubita, Naresh Kanumilli, Maisie Camm, Hood Thabit, Emma G. G. Wilmot
Summary: This study investigated the efficacy of intermittently scanned continuous glucose monitoring in patients with type 1 diabetes. The results showed that compared to traditional fingerstick testing, the use of intermittently scanned continuous glucose monitoring significantly reduced glycated hemoglobin levels and improved blood glucose control.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Caroline T. B. Juel, Thomas F. Dejgaard, Carsten P. Hansen, Jan H. Storkholm, Tina Vilsboll, Asger Lund, Filip K. Knop
Summary: The study evaluated glycemic variability in totally pancreatectomized patients and compared it with HbA(1c)-matched patients with long-standing type 1 diabetes. Results showed higher CONGA(60 min) and time spent above range in PX patients compared to T1D patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Sua Lee, Soyoung Lee, Kyeong Min Kim, Jong Ho Shin
Summary: This study aimed to determine the usefulness of continuous glucose monitoring (CGM) for glycemic control and glycemic variability stabilization in patients with diabetes undergoing hemodialysis. The results showed that continuous glucose monitoring could be a promising tool for individualizing treatment strategies.
FRONTIERS IN MEDICINE
(2023)
Article
Endocrinology & Metabolism
Melanie A. Jackson, Andrew Ahmann, Viral N. Shah
Summary: Continuous glucose monitoring plays a crucial role in managing type 1 diabetes, and recent studies suggest its potential benefits in type 2 diabetes as well, improving glycemic control and reducing the risk of hypoglycemia. Further research is needed to explore the utility of CGM in this population.
DIABETES TECHNOLOGY & THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Nicola Minuto, Marta Bassi, Carolina Montobbio, Francesco Vinci, Claudia Mercuri, Francesca Nastasia Perri, Mara Cabri, Maria Grazia Calevo, Giuseppe d'Annunzio, Mohamad Maghnie
Summary: The study aimed to evaluate the impact of the Italian lockdown on glycemic control in young patients with T1D. The results showed unexpected improvement in glycemic control during the lockdown, especially in patients aged 14 and above. Despite reduced physical activity, intense exercisers showed significant improvement in glycemic control during the lockdown.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Stacey Uhl, Anuja Choure, Benjamin Rouse, Aggee Loblack, Peter Reaven
Summary: In adults with type 2 diabetes mellitus, the use of continuous glucose monitors (CGMs) led to modest but statistically significant declines in HbA1c levels. The results were consistent for both real-time CGM and flash CGM, with trends favoring real-time CGM for other glucose metrics. However, longer term studies are needed to establish the impact of short-term glucose control improvements on important clinical outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Pediatrics
Yu Ding, Wenhao Zhang, Xiumei Wu, Tian Wei, Xulin Wang, Xueying Zheng, Sihui Luo
Summary: By comparing the glycemic control between holidays and schooldays in children and adolescents with T1D, this study found that nocturnal glycemic control was worse during schooldays. Girls, patients with longer duration, and insulin pump users had a higher risk of worsening nighttime glycemia during schooldays.
FRONTIERS IN PEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Ben Broos, Sara Charleer, Nancy Bolsens, Carolien Moyson, Chantal Mathieu, Pieter Gillard, Christophe De Block
Summary: The study found that diabetes knowledge and health literacy impact glycemic control, with higher diabetes knowledge and health literacy scores associated with improved glycemic control.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Eslam Montaser, Chiara Fabris, Boris Kovatchev
Summary: This study aimed to identify the principal dimensions of glycemic control and found that the glycemic-metric space has a true dimensionality of 2. Principal component analysis confirmed two essential metrics, treatment efficacy and treatment safety, which explained most of the variance.
DIABETES TECHNOLOGY & THERAPEUTICS
(2022)
Article
Endocrinology & Metabolism
Hidenori Yoshii, Tomoya Mita, Naoto Katakami, Yosuke Okada, Takeshi Osonoi, Katsumi Aso, Akira Kurozumi, Satomi Wakasugi, Fumiya Sato, Ryota Ishii, Masahiko Gosho, Iichiro Shimomura, Hirotaka Watada
Summary: Higher HbA1c levels do not always protect against hypoglycemic episodes. Our data demonstrate that using CGM metrics to complement HbA1c monitoring is beneficial, especially in older people, users of insulin and/or sulfonylureas, and patients with chronic kidney disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Yongwen Zhou, Xiaodong Mai, Hongrong Deng, Daizhi Yang, Mao Zheng, Bin Huang, Linlin Xu, Jianping Weng, Wen Xu, Jinhua Yan
Summary: This study explored the differences in glycemic metrics between FreeStyle Libre and iPro2 in adults with type 1 diabetes mellitus. The results showed that these two devices provided different estimations on time in range, coefficient of variation, and hypoglycemia-related parameters during the 14-day period of use.
JOURNAL OF DIABETES
(2022)
Article
Endocrinology & Metabolism
Tyger Lin, Jacquelyn A. Manfredo, Nicole Illesca, Kai Abiola, Nearry Hwang, Sandra Salsberg, Yasmin Akhtar, Nestoras Mathioudakis, Elizabeth A. Brown, Risa M. Wolf
Summary: Placing a sample CGM at the point of care can improve uptake of personal CGM and may help mitigate disparities in CGM use in minority and underserved youth. Long-term studies are needed to determine how similar interventions impact glycemic control and patient outcomes.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Samir Assaad Khalil, Noha Gaber Amin, Atef Mohamed Ibrahim, Doaa Zakaria Zaky, Mariam Mounir Bishay
Summary: The study found no significant difference in the average GI of dates between patients with T2DM and healthy subjects, but there was a significant difference in the time of peak blood glucose among different types of date-containing meals in patients with T2DM. Dates have a low GI, and CGMS has potential value in studying postprandial glucose excursions in patients with T2DM.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Endocrinology & Metabolism
Rong Huang, Huiying Wang, Ziyang Shen, Tingting Cai, Yunting Zhou, Yuming Wang, Wenqing Xia, Bo Ding, Rengna Yan, Huiqin Li, Jindan Wu, Jianhua Ma
Summary: This study found that increased glycemic variability is associated with osteoporosis in patients with type 2 diabetes. Age, gender, BMI, LDL-C, and SUA were also identified as factors related to osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Orthopedics
Fatemeh Baghbani-Naghadehi, Susan Armijo-Olivo, Carla M. Prado, Linda J. Woodhouse
Summary: This study investigated the association between obesity, comorbidities, and peri/postoperative complications in patients who underwent TKA surgery. The findings showed that patients with higher BMI or comorbidities were more likely to experience complications, particularly diabetes, pulmonary embolism, and wound infection.
JOURNAL OF KNEE SURGERY
(2023)
Article
Nutrition & Dietetics
Fabiana Lascala, Bruna Karoline da Silva Moraes, Maria Carolina Santos Mendes, Mariluce Barbosa de Carvalho, Sandra Regina Branbilla, Ademar Dantas da Cunha Junior, Luiz Roberto Lopes, Nelson Adami Andreollo, Ligia Traldi Macedo, Carla M. Prado, Jose Barreto Campello Carvalheira
Summary: This study aimed to investigate the association between systemic inflammation and myosteatosis upon diagnosis of gastric cancer (GC) and their predictive role in survival outcomes. The study found that patients with low skeletal muscle radiodensity were more likely to be older, have a higher body mass index, and have diabetes. High skeletal muscle radiodensity was associated with better disease-free survival and overall survival. Patients with a neutrophil-to-lymphocyte ratio (NLR) > 2.3 and myosteatosis had the worst survival outcomes.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Carla M. Prado, Katherine L. Ford, M. Cristina Gonzalez, Lisa C. Murnane, Chelsia Gillis, Paul E. Wischmeyer, Chet A. Morrison, Dileep N. Lobo
Summary: Preoperative nutrition assessment and intervention are crucial for improving postoperative outcomes. The Global Leadership Initiative for Malnutrition (GLIM) criteria are increasingly used in surgical settings to diagnose malnutrition, and novel approaches to assessing muscle mass can identify at-risk patients. Screening and assessing frailty can determine the cost/benefit of surgery and the value of interventions. Evaluation of nutrition risk and status is essential for predicting and mitigating surgical outcomes.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Chet Morrison, Carla M. Prado, Paul Wischmeyer, Robert G. Martindale, Jose Pimiento, Jennifer Katz, Jeffrey Mechanick, Jayshil J. Patel
Summary: Patients requiring complex or extensive surgery often face perioperative and postoperative nutrition risk. Providing adequate nutrition to these patients remains a clinical challenge. The American Society for Parenteral and Enteral Nutrition 2022 Preconference discussed novel strategies for assessing nutrition risk, enhancing recovery after surgery, and managing nutrition before and after surgery in complex surgical patients.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Amy A. Kirkham, Katherine L. Ford, Bruna Ramos Da Silva, Jordan Topolnyski, Carla M. Prado, Anil A. Joy, D. Ian Paterson, Normand Boule, Edith Pituskin, Mark J. Haykowsky, Richard B. Thompson
Summary: This study evaluated the feasibility and preliminary efficacy of telephone-based delivery of weekday-only time-restricted eating. The results showed that telephone-delivered weekday TRE was a feasible, acceptable, low-symptom, and low-cost intervention. However, despite clinically relevant changes occurring within individual participants, there were no significant changes in overall metabolic syndrome, lipid profile, or hemoglobin A(1c) and no changes in hepatic steatosis and thigh myosteatosis. Dietary intake changes included reduced energy and protein, while physical activity and sleep did not change.
Article
Endocrinology & Metabolism
Bruna Ramos da Silva, Camila E. Orsso, Maria Cristina Gonzalez, Juliana Maria Faccioli Sicchieri, Mirele Savegnago Mialich, Alceu A. Jordao, Carla M. Prado
Summary: Phase angle, a composite measure of bioelectrical impedance analysis, has been explored as an indicator of cellular health, inflammation, and oxidative stress. It has been shown to be associated with markers of inflammation and oxidative stress, suggesting its potential utility in early detection and monitoring of these conditions.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Oncology
Maurizio Muscaritoli, Gil Bar-Sela, Nicolo Matteo Luca Battisti, Borislav Belev, Jorge Contreras-Martinez, Enrico Cortesi, Ione de Brito-Ashurst, Carla M. Prado, Paula Ravasco, Suayib Yalcin
Summary: Early identification of malnourished or at-risk patients is essential for optimizing treatment success in oncology. The PRONTO protocol provides guidance for oncologists to identify and evaluate patients with malnutrition or muscle depletion and offers support options. Its adaptability makes it feasible for implementation in different settings and countries, particularly where specialized nutrition care is not available.
Review
Nutrition & Dietetics
Montserrat Montes-Ibarra, Camila E. Orsso, Ana Teresa Limon-Miro, Maria Cristina Gonzalez, Emanuele Marzetti, Francesco Landi, Steven B. Heyms, Rocco Barazzoni, Carla M. Prado
Summary: This study summarized the evidence on body composition abnormalities and their relationship with adverse clinical outcomes in patients with COVID-19. The findings showed that body composition abnormalities were prevalent among patients, with lower muscle density and decreased phase angle being associated with higher mortality risk, while increased visceral adipose tissue was associated with higher risk of ICU admission.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Katherine L. Ford, Claude Pichard, Michael B. Sawyer, Claire F. Trottier, Ilana Roitman Disi, Sarah A. Purcell, Sunita Ghosh, Mario Siervo, Nicolaas E. P. Deutz, Carla M. Prado
Summary: This study aimed to assess TEE in cancer patients, identify its predictors, and compare it with cancer-specific predicted energy requirements. The results showed that absolute TEE was higher in males, patients with colon cancer, and patients with obesity. TEE was lower than predicted requirements, indicating the need for improved assessment of energy requirements in cancer patients.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Oncology
Bruna Ramos Da Silva, Amy A. Kirkham, Katherine L. Ford, Mark J. Haykowsky, D. Ian Paterson, Anil A. Joy, Edith Pituskin, Richard Thompson, Carla M. Prado
Summary: This study investigated the effects of weekday time-restricted eating (TRE) on body composition. The results showed that TRE led to a decrease in body weight and total fat mass, and had a positive impact on body composition in individuals with obesity.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2023)
Review
Nutrition & Dietetics
Julia Montenegro, Anissa M. Armet, Benjamin P. Willing, Edward C. Deehan, Priscila G. Fassini, Joao F. Mota, Jens Walter, Carla M. Prado
Summary: The gut microbiome has a significant impact on energy metabolism, but there is a lack of evidence for its causal relationship and mechanisms in humans.
ADVANCES IN NUTRITION
(2023)
Article
Geriatrics & Gerontology
Nicole Kiss, Carla M. Prado, Robin M. Daly, Linda Denehy, Lara Edbrooke, Brenton J. Baguley, Steve F. Fraser, Abbas Khosravi, Gavin Abbott
Summary: This study compared the prevalence of low muscle mass, malnutrition, and sarcopenia in cancer patients from the UK Biobank, and explored the influence of different methods of adjusting muscle mass estimates. The study found that all conditions were associated with increased mortality risk. Adjusting muscle mass for body mass index identified more cases in obese participants.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Nutrition & Dietetics
Bruna Ramos Da Silva, Amy A. Kirkham, Katherine L. Ford, Mark J. Haykowsky, D. Ian Paterson, Anil A. Joy, Edith Pituskin, Richard Thompson, Carla M. Prado
Summary: The aim of this study was to evaluate the association between phase angle (PhA) obtained from bioelectrical impedance analysis (BIA) and health-related physical fitness (including cardiorespiratory fitness, skeletal muscle volume, and myosteatosis) among older breast cancer survivors. The results showed that higher values of PhA were associated with better health-related physical fitness among this population.
CLINICAL NUTRITION ESPEN
(2023)
Article
Health Care Sciences & Services
Kyle S. Weber, Elizabeth Godkin, Benjamin F. Cornish, William E. McIlroy, Karen Van Ooteghem
Summary: This study aimed to determine the accuracy of wrist-based estimates of physical activity (PA) intensity during walking in older adults and individuals with cerebrovascular disease or neurodegenerative disease, and explore factors that influence wrist-derived intensity estimates. The results showed that wrist-derived intensity classification during walking is prone to misclassification, and older age and variable wrist movement are associated with increased sedentary time based on wrist-derived estimates. Therefore, a multi-device approach may be necessary to accurately assess PA in these populations.
JMIR FORMATIVE RESEARCH
(2023)
Review
Critical Care Medicine
Paul E. Wischmeyer, Danielle E. Bear, Mette M. Berger, Elisabeth De Waele, Jan Gunst, Stephen A. Mcclave, Carla M. Prado, Zudin Puthucheary, Emma J. Ridley, Greet Van den Berghe, Arthur R. H. van Zanten
Summary: Personalization of ICU nutrition is important for the future of critical care. Guidelines recommend low-dose enteral or parenteral nutrition within 48 hours of admission, with consideration for alternative routes when necessary. Indirect calorimetry should be used to measure energy expenditure, and protein delivery should be adjusted based on patient stability. Micronutrient evaluation and muscle monitoring are also important considerations in post-ICU nutrition. Further research is needed on specialized anabolic nutrients and rehabilitation interventions for post-ICU recovery.